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BRAIN TEMPERATURE MONITORING IN NEONATES (PHASE II)

新生儿脑温度监测（第二阶段）

基本信息

批准号：
7492101
负责人：
KENNETH L CARR
金额：
$ 36.52万
依托单位：
MERIDIAN MEDICAL SYSTEMS, LLC
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-12-15 至 2010-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Hypoxic-ischemic encephalopathy (HIE) represents a serious problem in newborns, occurring in 3-9 of every 1,000 term infants, with about half of these HIE babies dying or suffering life-long severe handicaps, such as mental retardation or cerebral palsy. Current efforts to reduce the effects of HIE by hypothermia (cooling) have been hampered by the lack of a reliable noninvasive method of monitoring the infant's brain temperature during the hypothermic treatment, which lasts about 48 hours. The primary objective of this Phase I feasibility study was to evaluate Passive Microwave Radiometry (PMR) for monitoring intracranial temperature in neonates. The Phase I program has been successfully completed. The significant challenge of the overall program occurs in Phase II involving the integration of the radiometric receivers into the transducers and developing the logic and circuitry required to combine the two radiometric outputs to determine temperature at depth. The goal of the Phase II program is to develop an affordable system for the reliable and continuous monitoring of intracranial temperature in neonates. 7. Project Narrative Two to four of every 1000 babies delivered in the United States experience an obstetrical complication resulting in asphyxial injury to the brain leading to the development of cerebral palsy, mental retardation or even death. Recent clinical studies have shown that hypothermia decreases the injured brain's metabolism and oxygen requirements, and can significantly decrease the chances of physical disability and death. Although promising, hypothermia is an evolving therapy and there is much to learn regarding the optimal degree and duration of hypothermia. Knowledge of exact brain temperature is needed before these important questions can be adequately answered.

描述（由申请人提供）：缺氧缺血性脑病（HIE）是新生儿中的一个严重问题，每1,000名足月婴儿中有3-9名发生，其中约一半的HIE婴儿死亡或患有终身严重残疾，如智力迟钝或脑瘫。目前通过低温（冷却）来减少HIE影响的努力受到了缺乏可靠的非侵入性方法的阻碍，该方法可以在持续约48小时的低温治疗期间监测婴儿的大脑温度。本I期可行性研究的主要目的是评价被动微波辐射测量（PMR）用于监测新生儿颅内温度。第一阶段计划已顺利完成。整个计划的重大挑战出现在第二阶段，涉及将辐射接收器集成到传感器中，并开发联合收割机组合两种辐射输出以确定深度温度所需的逻辑和电路。第二阶段计划的目标是开发一个负担得起的系统，用于可靠和连续监测新生儿颅内温度。7.在美国，每1000名分娩的婴儿中就有2到4名经历产科并发症，导致大脑窒息性损伤，导致脑瘫、智力迟钝甚至死亡。最近的临床研究表明，低温降低了受损大脑的代谢和氧气需求，可以显着降低身体残疾和死亡的机会。虽然有前途，低温是一种不断发展的治疗方法，有很多关于低温的最佳程度和持续时间的学习。在这些重要问题得到充分回答之前，需要准确的大脑温度知识。