COGNITIVE CAPACITY & LANGUAGE COMPREHENSION--FMR STUDIES

描述(申请人摘要)：建议的研究适用于 从资源理论到处理语言的大规模大脑网络， 提出并验证了一种功能映射理论 认知水平的加工和大脑水平的神经元活动。 研究通过改变需求的类型和数量来检查这种映射 关于资源和资源的供应(在现有的 计算模型)，并通过评估与 功能磁共振成像(FMRI)。这些研究调查了 需求和流程类型对关联的激活的影响 韦尼克面积，以及语言系统与更一般的关系 中央执行长。与其用脑部成像来问“哪些脑区 激活？我们会问，网络中的每个区域在多大程度上 在不同的任务条件下激活，以及它们作为 资源需求和供给的作用？从资源的强度模式看 大脑激活，我们将构建模型的协调和 句子中涉及的潜在成分过程的相互作用 理解，建立在我们现有的模拟模型之上。这些研究使用了 尖端技术和方法，利用速度和 回波平面功能磁共振成像的敏感性以及行为研究和 计算模型，以开发一个完整的特征 语言的认知加工与组织的关系 语言背后的大脑系统。 这项研究提供了大脑活动和功能之间的直接联系 语言处理障碍。该方法允许评估 卒中失语后以及治疗前和治疗后的大脑和认知功能 在治疗之后。新的范例成功地确定了 术前患者的部分语言网络。此外，还有一个 这种方法的明确承诺有助于分析语言障碍 没有失语症那么具体，比如自闭症的断连方面， 帕金森氏症的语言障碍和弥漫性疾病，如 老年痴呆症。

DESCRIPTION (Applicant's Abstract): The proposed research applies a resource theory to the large-scale brain network that processes language, proposing and testing a theory of the mapping between the functional processing at the cognitive level and neuronal activity at the brain level. The research examines this mapping by varying the type and amount of demand on resources and the supply of resources (as operationalized in an existing computational model) and by assessing the associated brain activation with functional Magnetic Resonance Imaging (fMRI). The studies investigate the effect of demand and type of process on the activation associated with Wernicke's area, and the relation of the language system to the more general central executive. Instead of using brain imaging to ask "which brain areas activate?" We will ask "to what degree does each area in the network activate under different task conditions and how do they interact as a function of resource demand and supply?" From the intensity patterns of the brain activation, we will construct models of the coordination and interaction of the underlying component processes involved in sentence comprehension, building on our existing simulation model. The studies use cutting-edge technologies and methodologies, exploiting the speed and sensitivity of echo-planar fMRI as well as behavioral studies and computational modeling to develop an integrated characterization of the relation between the cognitive processing of language and the organization of the brain systems underlying language. The research provides a direct link between brain activity and functional disorders in language processing. The approach allows the assessment of brain and cognitive function after stroke-induced aphasia, and before and after therapy. The new paradigm succeeds in identifying the location of parts of the language network in presurgical patients. Moreover, there is a clear promise of this approach helping to analyze language impairments that are less specific than aphasia, such as the disconnection facets of autism, Parkinsonian impairments of language, and diffuse diseases such as Alzheimer's.