Investigating the renal microvasculature in polycystic kidney disease

研究多囊肾病的肾脏微血管系统

• 批准号: MR/P018629/1
• 负责人: David Long
• 金额: $ 51.59万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP018629%2F1
• 关键词: Investigating; renal; microvasculature; polycystic; kidney

60,000 people in the UK have long term severe kidney disease. There is currently no cure and patients require dialysis or transplantation. One of the leading causes of long term kidney disease is polycystic kidneys. Our previous work has shown that one of the earliest events in the progressive decline of polycystic kidneys is changes in the small blood vessels of the kidney. Furthermore, we have shown that treatments using proteins which restore and stabilise these blood vessels improve disease progression. However, we do not yet fully understand how these treatments work. This will be investigated in this proposal by a team of scientists and clinicians based at the UCL Great Ormond Street Institute of Child Health and the University of Manchester using high resolution imaging, high-throughput sequencing technology and models which replicate polycystic kidney disease. These investigations will enhance our knowledge of how blood vessels are involved in kidney health and disease. Furthermore, if these studies are successful, it could be a new exciting therapeutic avenue for kidney patients in the future.

英国60,000人患有长期严重的肾脏疾病。目前没有治愈方法，患者需要透析或移植。长期肾脏疾病的主要原因之一是多囊性肾脏。我们以前的工作表明，多囊性肾脏逐渐下降的最早事件之一是肾脏小血管的变化。此外，我们已经表明，使用蛋白质恢复和稳定这些血管的蛋白质可以改善疾病进展。但是，我们尚未完全了解这些治疗方法的工作方式。这将在本提案中，由UCL大奥蒙德街儿童健康研究所和曼彻斯特大学的一组科学家和临床医生组成，使用高分辨率成像，高通量测序技术和模型复制多囊肾脏病。这些研究将增强我们对血管如何参与肾脏健康和疾病的了解。此外，如果这些研究成功，那么将来可能是肾脏患者的新型治疗途径。

项目成果

Diabetic Nephropathy - Methods and Protocols

糖尿病肾病 - 方法和方案

• DOI: 10.1007/978-1-4939-9841-8_8
• 发表时间: 2020
• 作者: Jafree D

The timing of auditory sensory deficits in Norrie disease has implications for therapeutic intervention.

• DOI: 10.1172/jci.insight.148586
• 发表时间: 2022-02-08
• 期刊: JCI insight
• 影响因子: 8
• 作者: Bryant D;Pauzuolyte V;Ingham NJ;Patel A;Pagarkar W;Anderson LA;Smith KE;Moulding DA;Leong YC;Jafree DJ;Long DA;Al-Yassin A;Steel KP;Jagger DJ;Forge A;Berger W;Sowden JC;Bitner-Glindzicz M
• 通讯作者: Bitner-Glindzicz M

Mechanisms and cell lineages in lymphatic vascular development.

• DOI: 10.1007/s10456-021-09784-8
• 发表时间: 2021-05
• 期刊: Angiogenesis
• 影响因子: 9.8
• 作者: Jafree DJ;Long DA;Scambler PJ;Ruhrberg C
• 通讯作者: Ruhrberg C