Is gestational diabetes associated with adverse maternal and child mental health outcomes?

妊娠糖尿病与不良的母婴心理健康结果相关吗？

• 批准号: MR/P019293/1
• 负责人: Claire Wilson
• 金额: $ 35.76万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP019293%2F1
• 关键词: gestational; diabetes; associated; adverse; maternal

Gestational diabetes mellitus (GDM) is diabetes (i.e. sugar levels being too high in the blood) arising during pregnancy. Around one in 20 pregnant women are affected in the UK. Mental illness during pregnancy is even more prevalent and is the most common illness to affect women during the perinatal period (during pregnancy or one year following delivery), with around one in five affected in the UK. While it is known that depression is twice as common in the general population amongst those who have diabetes, as those who do not, less is known about the link between mental illness and GDM, including how common mental illness is in those with GDM. Even less is known about potential reasons for a relationship between GDM and mental illness in the perinatal period. Both GDM and perinatal mental illness have been linked to possible emotional problems and learning delays in the child. However the effect of having both mental illness and GDM on the child has never been studied. Yet both GDM and mental illnesses are preventable conditions. During the proposed fellowship I will:1) Investigate the extent to which GDM increases the risk of perinatal mental illness.2) Investigate whether or not mothers with GDM who also have mental illness during pregnancy are more likely to go on to develop diabetes in the future.3) Compare the development of children whose mothers had GDM and mental illness during pregnancy to those whose mothers had GDM but no mental illness. If links are found, reasons for these will be explored.In my first study, I will systematically review the existing relevant research literature, assessing its quality, to inform my own research methods. During this review, I will aim to calculate how common mental illnesses are during pregnancy and in the year following delivery for women with GDM in order to ascertain the extent of the risk for mental illness in women have GDM. I will also explore potential reasons why this might be.In my second study, I will use information collected from a group of mothers and their children in Bradford (called the Born in Bradford: BiB study) to answer each of my research questions. All mothers in the study were offered a test for GDM. This will provide information on which mothers had GDM (681 cases of GDM from 9779 women in total) then I can examine to what extent these women are more likely to have mental illnesses than women without GDM. Diagnoses of diabetes up to the present day in mothers following their diagnosis of GDM will also be available from primary care records. This will mean I can examine whether women with GDM and mental illness are more likely to develop diabetes after birth compared with women with GDM and no illness. I will then use two assessments completed by the child's teacher to examine the effects of GDM and mental illness in the mother on the child. One is of their emotional development (from a standard questionnaire) at the age of four years and the other is of their performance at school from national assessments at the age of seven years. In exploring potential reasons for significant links that I find, I will use information from the study about the mother's lifestyle such as diet and physical activity levels and blood tests from the newborn and mother.This research will provide knowledge and a better understanding of the link between GDM and mental illness. If it appears that mental illness in those with GDM influences the development of diabetes in the future and the development of the child then this research should help scientists to develop strategies for improving the long-term health of not only the mother but also her child.

妊娠糖尿病（GDM）是妊娠期间出现的糖尿病（即血液中的血糖水平过高）。在英国，大约每20名孕妇中就有一名受到影响。怀孕期间的精神疾病更为普遍，是围产期（怀孕期间或产后一年）影响女性的最常见疾病，在英国，大约五分之一的人受到影响。虽然众所周知，抑郁症在患有糖尿病的人群中是普通人群的两倍，但对精神疾病和GDM之间的联系知之甚少，包括GDM患者中精神疾病的常见程度。甚至更少的是知道潜在的原因之间的关系GDM和精神疾病在围产期。GDM和围产期精神疾病都与儿童可能的情绪问题和学习延迟有关。然而，患有精神疾病和GDM对孩子的影响从未被研究过。然而，GDM和精神疾病都是可以预防的疾病。在拟议的奖学金期间，我将：1）调查GDM增加围产期精神疾病风险的程度。2）调查在怀孕期间患有精神疾病的GDM母亲是否更有可能在未来发展为糖尿病。3）比较母亲在怀孕期间患有GDM和精神疾病的儿童与母亲患有GDM但没有精神疾病的儿童的发展。在第一项研究中，我将系统地回顾现有的相关研究文献，评估其质量，为我自己的研究方法提供信息。在这次审查中，我的目标是计算如何常见的精神疾病是在怀孕期间，并在分娩后的一年，为妇女与GDM，以确定精神疾病的风险程度在妇女有GDM。在第二项研究中，我将使用从布拉德福德的一组母亲和他们的孩子那里收集的信息（称为布拉德福德出生：围兜研究）来回答我的每一个研究问题。研究中的所有母亲都接受了GDM测试。这将提供哪些母亲患有GDM的信息（总共9779名妇女中有681例GDM），然后我可以检查这些妇女比没有GDM的妇女更容易患精神疾病的程度。到目前为止，在诊断为GDM的母亲中，糖尿病的诊断也将从初级保健记录中获得。这将意味着我可以检查与GDM和无疾病的女性相比，GDM和精神疾病的女性是否更容易在出生后患糖尿病。然后，我将使用孩子的老师完成的两个评估来检查GDM和母亲的精神疾病对孩子的影响。一个是他们四岁时的情感发展（来自标准问卷），另一个是他们七岁时在学校的表现，来自国家评估。在探索我发现的重要联系的潜在原因时，我将使用有关母亲生活方式的研究信息，如饮食和身体活动水平以及新生儿和母亲的血液测试。这项研究将提供知识和更好地理解GDM与精神疾病之间的联系。如果GDM患者的精神疾病似乎会影响未来糖尿病的发展和儿童的发展，那么这项研究应该有助于科学家制定改善母亲及其孩子长期健康的策略。

项目成果

Investigating Bullying as a Predictor of Suicidality in a Clinical Sample of Adolescents with Autism Spectrum Disorder.

在自闭症谱系障碍的青少年临床样本中，研究欺凌作为自杀性的预测指标。

• DOI: 10.1002/aur.2292
• 发表时间: 2020-06
• 期刊: Autism research : official journal of the International Society for Autism Research
• 作者: Holden R;Mueller J;McGowan J;Sanyal J;Kikoler M;Simonoff E;Velupillai S;Downs J
• 通讯作者: Downs J

The association between gestational diabetes and ASD and ADHD: a systematic review and meta-analysis.

• DOI: 10.1038/s41598-021-84573-3
• 发表时间: 2021-03-04
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Rowland J;Wilson CA
• 通讯作者: Wilson CA

Assessing the feasibility of a web-based outcome measurement system in child and adolescent mental health services - myHealthE a randomised controlled feasibility pilot study.

• DOI: 10.1111/camh.12571
• 发表时间: 2023-02
• 期刊: CHILD AND ADOLESCENT MENTAL HEALTH
• 影响因子: 6.1
• 作者: Morris, Anna C.;Ibrahim, Zina;Heslin, Margaret;Moghraby, Omer S.;Stringaris, Argyris;Grant, Ian M.;Zalewski, Lukasz;Pritchard, Megan;Stewart, Robert;Hotopf, Matthew;Pickles, Andrew;Dobson, Richard J. B.;Simonoff, Emily;Downs, Johnny
• 通讯作者: Downs, Johnny

Women with a history of postpartum affective disorder at increased risk of recurrence in future pregnancies.

有产后情感障碍病史的女性在未来怀孕时复发的风险增加。

• DOI: 10.1136/ebmental-2018-300009
• 发表时间: 2018
• 期刊: Evidence-based mental health
• 影响因子: 5.2
• 作者: Gordon H