Developing novel neuroimaging approaches to investigate the neural antecedents of tics and brain correlates of premonitory urges in Tourette syndrome
开发新的神经影像学方法来研究抽动秽语综合症抽动的神经前因和预兆冲动的大脑相关性
基本信息
- 批准号:MR/T032588/1
- 负责人:
- 金额:$ 68.41万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2021
- 资助国家:英国
- 起止时间:2021 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Tourette syndrome (TS) is a neurological condition of childhood onset that is characterised by motor and vocal tics. Many (~90%) people with TS report that their tics are preceded by a 'premonitory urge' (PU) that is described as uncomfortable bodily sensations that is experienced as a strong urge-to-tic. People who experience PU often report that they would not exhibit tics if they did not experience PU. For these reasons, we consider it timely and highly important to investigate the brain mechanisms that give rise to the urge to tic in TS using brain imaging techniques such as functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG).Unfortunately, scanning individuals with TS using conventional fMRI and MEG methods is extremely difficult due to their unwanted movements, which often lead to a very high (50-75%) loss of data. This problem is exacerbated if the individual is actually required to express their tic while being scanned (i.e., in conventional fMRI analyses it is necessary that tics actually occur so that the time course of the brain activity associated with producing the tic can be modelled). However, most TS patients can suppress their tics quite effectively: although tic suppression is associated with increasing levels of discomfort which is experienced as a strong urge-to-tic. This suggests that we might successfully scan many TS patients if we asked them to suppress their tics throughout the period they were being scanned. The objective of this project is to develop new approaches to imaging PU and the neural antecedents of tics in TS. One approach is based upon an alternative, data-driven, framework for the analysis of functional magnetic resonance imaging (fMRI) data, termed 'Multi-echo Sparse Paradigm Free Mapping' (ME-SPFM), in which we obtain fMRI measurements associated with PU that occur in TS without the necessity for tic expression. Using this approach, we will accurately and reliably identify functional brain activity that is associated with the occurrence of PU in circumstances where tics are effectively suppressed (i.e. there is no tic to use as an external timing event). The second approach involves our using an entirely novel form of wearable MEG device, developed at the University of Nottingham. MEG is a non-invasive brain imaging technique that has advantages over fMRI: not least it allows the measurement of ongoing brain activity at the millisecond scale. Using this device will allow us to record brain activity associated with PU, and the brain activity that precedes a tic, in patients with TS even when they are executing large head or body movements. A key focus of the MEG studies that we will carry out are that they will allow us to investigate how transiently-synchronising brain networks are assembled linking brain regions associated with the experience of the urge-for-action with brain networks involved in the initiation of action. Once again, these analyses will be conducted using novel, state-of-the-art, data-driven approaches to investigating changes in functional connectivity between brain areas.
多发性抽动症(TS)是一种以运动和声带痉挛为特征的儿童期发病的神经系统疾病。许多(约90%)的TS患者报告说,他们的抽搐之前会有一种先兆冲动(PU),这种冲动被描述为身体的不适感觉,被认为是强烈的抽搐冲动。体验过PU的人经常报告说,如果他们没有经历过PU,他们就不会表现出抽搐。基于这些原因,我们认为使用功能磁共振成像(FMRI)和脑磁图(MEG)等脑成像技术来研究TS患者抽动的脑机制是及时和非常重要的。不幸的是,使用传统的fMRI和MEG方法扫描TS患者是极其困难的,因为他们不想要的运动,这通常会导致非常高的(50%-75%)的数据丢失。如果个体在被扫描时实际上被要求表达他们的抽搐(即,在传统的fMRI分析中,抽搐实际上发生是必要的,以便可以对与产生抽搐相关联的大脑活动的时间进程进行建模),则该问题会加剧。然而,大多数TS患者可以相当有效地抑制他们的抽动:尽管抽动抑制与增加的不适程度有关,这是一种强烈的抽动冲动。这表明,如果我们要求TS患者在接受扫描期间抑制他们的抽搐,我们可能会成功扫描许多TS患者。该项目的目标是开发新的方法,以成像PU和抽动的神经前驱在TS。一种方法是基于用于分析功能磁共振成像(FMRI)数据的另一种数据驱动的框架,该框架被称为“多回波稀疏范式自由映射”(ME-SPFM),在该框架中,我们获得与出现在TS中的PU相关的fMRI测量,而不需要TIC表达。使用这种方法,我们将准确和可靠地识别在抽动被有效抑制的情况下(即没有抽搐可用作外部计时事件)与PU发生相关的功能性大脑活动。第二种方法涉及我们使用一种全新的可穿戴式脑磁图设备,该设备由诺丁汉大学开发。脑磁图是一种非侵入性的脑成像技术,它比功能磁共振成像有优势:尤其是它允许在毫秒级测量正在进行的大脑活动。使用该设备将允许我们记录与PU相关的大脑活动,以及抽搐之前的大脑活动,即使在TS患者执行大型头部或身体运动时也是如此。我们将开展的脑磁图研究的一个关键焦点是,它们将使我们能够调查瞬时同步的大脑网络是如何组装起来的,将与行动冲动体验相关的大脑区域与参与行动启动的大脑网络联系起来。再一次,这些分析将使用新颖的、最先进的、数据驱动的方法来研究大脑区域之间功能连接的变化。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Task-dependent plasticity in distributed neural circuits after transcranial direct current stimulation of the human motor cortex: A proof-of-concept study.
- DOI:10.3389/fpain.2022.1005634
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
The Neurobiology of the Gilles De La Tourette Syndrome and Chronic Tics - Part B
Gilles De La Tourette 综合征和慢性抽动症的神经生物学 - B 部分
- DOI:10.1016/bs.irmvd.2021.11.006
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Houlgreave M
- 通讯作者:Houlgreave M
Task-Dependent Plasticity in Distributed Neural Circuits after Transcranial Direct Current Stimulation of the Human Motor Cortex
人类运动皮层经颅直流电刺激后分布式神经回路的任务依赖性可塑性
- DOI:10.2139/ssrn.3988621
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Hodkinson D
- 通讯作者:Hodkinson D
The Neurobiology of the Gilles De La Tourette Syndrome and Chronic Tics: Part A
Gilles De La Tourette 综合征和慢性抽动症的神经生物学:A 部分
- DOI:10.1016/bs.irmvd.2021.11.008
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Smith C
- 通讯作者:Smith C
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Stephen Jackson其他文献
Resistive loaded breathing has a functional impact on maximal voluntary contractions in humans
阻力负荷呼吸对人类最大自主收缩有功能性影响
- DOI:
- 发表时间:
2002 - 期刊:
- 影响因子:2.5
- 作者:
D. Turner;Stephen Jackson - 通讯作者:
Stephen Jackson
The descriptive complexity of the set of poisson generic numbers
泊松泛型数集的描述复杂性
- DOI:
10.1142/s0219061324500193 - 发表时间:
2023 - 期刊:
- 影响因子:0.9
- 作者:
V. Becher;Stephen Jackson;Dominik Kwietniak;B. Mance - 通讯作者:
B. Mance
Cultural issues in developing E-Government in Malaysia
马来西亚发展电子政务的文化问题
- DOI:
10.1080/01449290903300931 - 发表时间:
2010 - 期刊:
- 影响因子:3.7
- 作者:
M. Wong;Stephen Jackson;G. Philip - 通讯作者:
G. Philip
Understanding IS/IT implementation through metaphors: A multi-metaphor stakeholder analysis in an educational setting
- DOI:
10.1016/j.chb.2015.09.039 - 发表时间:
2016-02-01 - 期刊:
- 影响因子:
- 作者:
Stephen Jackson - 通讯作者:
Stephen Jackson
METHYLTRANSFERASE1 and ripening modulate vivipary during tomato fruit development
甲基转移酶1和成熟调节番茄果实发育过程中的胎生
- DOI:
10.1104/pp.20.00499 - 发表时间:
2020 - 期刊:
- 影响因子:7.4
- 作者:
Mengqin Yao;Wei Wei Chen;Junhua Kong;Xinlian Zhang;Nongnong Shi;Silin Zhong;Ping Ma;Philippe Gallusci;Stephen Jackson;Yule Liu;Yiguo Hong - 通讯作者:
Yiguo Hong
Stephen Jackson的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Stephen Jackson', 18)}}的其他基金
China Partnering Award: Transgene-free Gene Editing in Plants
中国合作奖:植物非转基因基因编辑
- 批准号:
BB/T018259/1 - 财政年份:2021
- 资助金额:
$ 68.41万 - 项目类别:
Research Grant
A rapid and efficient method to obtain germline gene editing in plants
一种快速有效的植物种系基因编辑方法
- 批准号:
BB/T011920/1 - 财政年份:2020
- 资助金额:
$ 68.41万 - 项目类别:
Research Grant
18-BTT EAGER: A system for the production of haploid inducer lines and cytoplasmic male sterile doubled haploids for efficient hybrid production
18-BTT EAGER:用于生产单倍体诱导系和细胞质雄性不育双单倍体的系统,用于高效杂交生产
- 批准号:
BB/S019995/1 - 财政年份:2019
- 资助金额:
$ 68.41万 - 项目类别:
Research Grant
Descriptive Dynamics and Borel Combinatorics of Group Actions
群体行为的描述动力学和 Borel 组合学
- 批准号:
1800323 - 财政年份:2018
- 资助金额:
$ 68.41万 - 项目类别:
Continuing Grant
Chemical reversion of nuclear shape and other defects of Hutchinson Gilford Progeria Syndrome and Lamin A/C depleted cells
哈钦森·吉尔福德早衰综合症和核纤层蛋白 A/C 耗尽细胞的核形状和其他缺陷的化学逆转
- 批准号:
MR/L019116/1 - 财政年份:2014
- 资助金额:
$ 68.41万 - 项目类别:
Research Grant
China:UK collaborative exchange: Systemic signalling in plants
中英合作交流:植物系统信号传导
- 批准号:
BB/K021079/1 - 财政年份:2013
- 资助金额:
$ 68.41万 - 项目类别:
Research Grant
Workshop in Inner Model Theory and Descriptive Set Theory
内模型理论和描述集合论研讨会
- 批准号:
1229043 - 财政年份:2012
- 资助金额:
$ 68.41万 - 项目类别:
Standard Grant
DISSERTATION RESEARCH: Spatial and Temporal Patterns of Ponderosa Pine Migration
论文研究:黄松迁移的时空模式
- 批准号:
0910173 - 财政年份:2009
- 资助金额:
$ 68.41万 - 项目类别:
Standard Grant
Manipulation of bolting time for improved quality and greater sustainability in lettuce production
控制抽苔时间以提高生菜生产的质量和更大的可持续性
- 批准号:
BB/G007330/1 - 财政年份:2009
- 资助金额:
$ 68.41万 - 项目类别:
Research Grant
International Research Workshop: Peatland Archives of Holocene Climate Variability
国际研究研讨会:全新世气候变化的泥炭地档案
- 批准号:
0907815 - 财政年份:2009
- 资助金额:
$ 68.41万 - 项目类别:
Standard Grant
相似国自然基金
Novel-miR-1134调控LHCGR的表达介导拟
穴青蟹卵巢发育的机制研究
- 批准号:
- 批准年份:2025
- 资助金额:10.0 万元
- 项目类别:省市级项目
novel-miR75靶向OPR2,CA2和STK基因调控人参真菌胁迫响应的分子机制研究
- 批准号:82304677
- 批准年份:2023
- 资助金额:30.00 万元
- 项目类别:青年科学基金项目
海南广藿香Novel17-GSO1响应p-HBA调控连作障碍的分子机制
- 批准号:82304658
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
白术多糖通过novel-mir2双靶向TRADD/MLKL缓解免疫抑制雏鹅的胸腺程序性坏死
- 批准号:
- 批准年份:2021
- 资助金额:30 万元
- 项目类别:青年科学基金项目
novel_circ_001042/miR-298-5p/Capn1轴调节线粒体能量代谢在先天性肛门直肠畸形发生中的作用机制研究
- 批准号:
- 批准年份:2021
- 资助金额:55 万元
- 项目类别:面上项目
novel-miR-59靶向HMGAs介导儿童早衰症细胞衰老的作用及机制研究
- 批准号:
- 批准年份:2021
- 资助金额:58 万元
- 项目类别:面上项目
novel_circ_008138/rno-miR-374-3p/SFRP4调控Wnt信号通路参与先天性肛门直肠畸形发生的分子机制研究
- 批准号:82070530
- 批准年份:2020
- 资助金额:55 万元
- 项目类别:面上项目
miRNA-novel-272通过靶向半乳糖凝集素3调控牙鲆肠道上皮细胞炎症反应的机制研究
- 批准号:32002421
- 批准年份:2020
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
m6A修饰介导的lncRNA WEE2-AS1转录后novel-pri-miRNA剪切机制在胶质瘤恶性进展中的作用研究
- 批准号:
- 批准年份:2020
- 资助金额:55 万元
- 项目类别:面上项目
miRNA/novel_167靶向抑制Dmrt1的表达在红鳍东方鲀性别分化过程中的功能研究
- 批准号:31902347
- 批准年份:2019
- 资助金额:25.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Does social motivation in adolescence differentially predict the impact of childhood threat exposure on developing suicidal thoughts and behaviors
青春期的社会动机是否可以差异预测童年威胁暴露对自杀想法和行为的影响
- 批准号:
10785373 - 财政年份:2023
- 资助金额:
$ 68.41万 - 项目类别:
Developing advanced diffusion MRI for early detection of Alzheimer's disease
开发先进的扩散磁共振成像技术以早期检测阿尔茨海默病
- 批准号:
10740034 - 财政年份:2023
- 资助金额:
$ 68.41万 - 项目类别:
Towards Developing Biomarkers for Premature Aging in Schizophrenia
开发精神分裂症过早衰老的生物标志物
- 批准号:
10739528 - 财政年份:2023
- 资助金额:
$ 68.41万 - 项目类别:
Utility of adaptive design optimization for developing rapid and reliable behavioral paradigms for substance use disorders
利用自适应设计优化来开发快速可靠的药物滥用行为范例
- 批准号:
10637895 - 财政年份:2023
- 资助金额:
$ 68.41万 - 项目类别:
Developing an Optogenetics Technology Based on Natural Potassium-selective Channelrhodopsins
开发基于天然钾选择性通道视紫红质的光遗传学技术
- 批准号:
10731153 - 财政年份:2023
- 资助金额:
$ 68.41万 - 项目类别:
Biological Risk Factors for the Prospective Development of Alcohol Use Disorders in Young Adults with Bipolar Disorder and Typically Developing Young Adults
患有躁郁症的年轻人和典型发育的年轻人未来发生酒精使用障碍的生物危险因素
- 批准号:
10583360 - 财政年份:2023
- 资助金额:
$ 68.41万 - 项目类别:
Toward developing a novel English educational method by visualizing English skills through fNIRS-based neuroimaging
通过基于 fNIRS 的神经影像可视化英语技能,开发一种新颖的英语教育方法
- 批准号:
22H00681 - 财政年份:2022
- 资助金额:
$ 68.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Tracking neurocognitive changes during evidence-based reading instruction in typically and atypically developing children
跟踪典型和非典型发育儿童的循证阅读教学期间的神经认知变化
- 批准号:
10698010 - 财政年份:2022
- 资助金额:
$ 68.41万 - 项目类别:
Prenatal Maternal Stress, Exposure to Environmental Chemicals, and Cognitive Development: Potential Roles for Inflammation and the Developing Gut Microbiome
产前母亲压力、环境化学物质暴露和认知发展:炎症和肠道微生物群发育的潜在作用
- 批准号:
10688283 - 财政年份:2022
- 资助金额:
$ 68.41万 - 项目类别:
UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate Intoxication
加州大学戴维斯分校 CounterACT 卓越中心:制定缓解急性有机磷中毒慢性神经系统后果的治疗策略
- 批准号:
10852174 - 财政年份:2022
- 资助金额:
$ 68.41万 - 项目类别: