Investigating SARS-CoV-2 Transmission in UK Jewish Communities

调查英国犹太社区的 SARS-CoV-2 传播情况

• 批准号: MR/V027956/1
• 负责人: Michael Marks
• 金额: $ 32.01万
• 依托单位: London School of Hygiene & Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV027956%2F1
• 关键词: Investigating; SARS; CoV; Transmission; UK

Like other ethnic minority groups, Jewish communities have been particularly badly affected by COVID-19. This may be because they have much larger families than the UK average and because members of this community mix more frequently or in different ways than in other parts of the UK population. In addition members of these communities often obtain information about health related issues from different sources.In this study we will survey households in a UK Jewish community and collect samples to test for evidence of COVID-19 infection. We will interview members of the community to understand people's understanding of risks from COVID-19 and how acceptable different future control strategies might be. We will use this data to understand how transmission spread in this community and in particular whether the larger households and higher number of children in this community played an important role in driving the high rates of COVID-19 seen. Locally information will be disseminated in collaboration with local community groups.Overall this information will help us better understand transmission in high-risk communities and the role of children in transmission of COVID-19.

与其他少数民族群体一样，犹太社区受到COVID-19的影响尤其严重。这可能是因为他们的家庭比英国平均家庭大得多，也可能是因为这个社区的成员比英国其他地区的人口更频繁地混合或以不同的方式混合。此外，这些社区的成员经常从不同来源获得有关健康相关问题的信息。在这项研究中，我们将调查英国犹太社区的家庭，并收集样本以检测COVID-19感染的证据。我们将与社区成员进行访谈，以了解人们对COVID-19风险的理解，以及未来不同控制策略的可接受程度。我们将利用这些数据来了解该社区的传播情况，特别是该社区的较大家庭和较多儿童是否在推动COVID-19高发病率方面发挥了重要作用。在当地，我们将与当地社区团体合作传播相关信息。总体而言，这些信息将有助于我们更好地了解高风险社区的传播情况以及儿童在COVID-19传播中的作用。

项目成果

Investigating the role of whole genome sequencing in syphilis epidemiology: an English case study

调查全基因组测序在梅毒流行病学中的作用：英国案例研究

• DOI: 10.1101/2022.12.02.22283031
• 发表时间: 2022
• 作者: Beale M

SARS-CoV-2 seroprevalence in a strictly-Orthodox Jewish community in the UK: A retrospective cohort study.

• DOI: 10.1016/j.lanepe.2021.100127
• 发表时间: 2021-07
• 期刊: The Lancet regional health. Europe
• 作者: Gaskell KM;Johnson M;Gould V;Hunt A;Stone NR;Waites W;Kasstan B;Chantler T;Lal S;Roberts CH;Goldblatt D;Eggo RM;Marks M
• 通讯作者: Marks M

The potential for vaccination-induced herd immunity against the SARS-CoV-2 B.1.1.7 variant.

• DOI: 10.2807/1560-7917.es.2021.26.20.2100428
• 发表时间: 2021-05
• 期刊: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
• 作者: Hodgson D;Flasche S;Jit M;Kucharski AJ;CMMID COVID-19 Working Group;Centre for Mathematical Modelling of Infectious Disease (CMMID) COVID-19 Working Group
• 通讯作者: Centre for Mathematical Modelling of Infectious Disease (CMMID) COVID-19 Working Group

Model Integration in Computational Biology: The Role of Reproducibility, Credibility and Utility.

• DOI: 10.3389/fsysb.2022.822606
• 发表时间: 2022-01-01
• 期刊: Frontiers in systems biology
• 作者: Karr, Jonathan;Malik-Sheriff, Rahuman S;Kulesza, Alexander
• 通讯作者: Kulesza, Alexander

Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilis.

• DOI: 10.1038/s41564-021-01000-z
• 发表时间: 2021-12
• 期刊: Nature microbiology
• 影响因子: 28.3
• 作者: Beale MA;Marks M;Cole MJ;Lee MK;Pitt R;Ruis C;Balla E;Crucitti T;Ewens M;Fernández-Naval C;Grankvist A;Guiver M;Kenyon CR;Khairullin R;Kularatne R;Arando M;Molini BJ;Obukhov A;Page EE;Petrovay F;Rietmeijer C;Rowley D;Shokoples S;Smit E;Sweeney EL;Taiaroa G;Vera JH;Wennerås C;Whiley DM;Williamson DA;Hughes G;Naidu P;Unemo M;Krajden M;Lukehart SA;Morshed MG;Fifer H;Thomson NR
• 通讯作者: Thomson NR