Train the Trainer in Data Science for Pathogen Genomics and Surveillance

随着英国研究人员和医疗专业人员的工作性质发生变化，并需要纳入大数据、测序和基因组学，对数据科学专业知识的需求日益增长，以支持他们的工作，其中包括临床科学家、专业注册员或医学微生物学顾问。虽然英国的课程向这些受众传授一些基因组学、数据分析和解释，但大多数培训都留给了研究生课程和其他独立培训机构的高级专业课程。这一提议的动机是对与传染病病原体相关的基因组学的数据科学技能培训的巨大需求，以及对熟练培训人员的日益增长的需求。我们的目标是提高整个英国的培训能力，能够为临床微生物学领域的医疗保健专业人员提供病原体基因组学和监测方面的数据科学教育。我们计划通过以下方式实现这一目标：1)实施一系列培训师(TT)课程；2)提供指导和鼓励建立网络；3)建立和发布免费可用的培训资源。虽然定期培训课程为个别参与者提供了如何分析和解释他们自己的数据的技能，但TTT方法应用了向前教学的概念，并使已经在病原体基因组数据科学方面有知识的专业人员掌握了培训其他人所需的技能。一个关键的重点将是培训参与者的教学和促进技能。我们还将开发基于项目的学习方法，指导参与者构建自己的培训材料。然后是面对面的会议，他们将演示如何向他人提供培训，并将收到关于他们的教学方法的反馈。将通过导师和网络，支持参与者在他们的研究或工作环境中提供培训。到项目结束时，我们将出版免费可用的、随时可用的培训资源，供英国病原体基因组学数据科学的培训人员使用。这项建议汇集了基因组病原体监测中心(CGPS)和惠康基因组校园高级课程和科学会议(ACSC)的专业知识，这两家机构此前曾合作举办过几个课程，包括“培训培训者能力建设，以监测低分子和中等收入国家AMR的基因组监测”(2019年，惠康基因组校园)。CGPS的工作是通过生成开放获取的工具，在全球范围内解释当地序列数据，将病原体传播的分析和AMR研究转化为公共健康效益。CGPS在所有方面都拥有建立基因组AMR监测能力所需的经验，这些经验来自与哥伦比亚、印度、尼日利亚和菲律宾的实验室合作运营的NIHR全球卫生研究单位。ACSC在为研究人员和医疗保健专业人员提供培训课程方面拥有30多年的经验。主要课程包括临床微生物学基因组学和临床病毒学基因组学，主要面向英国的基因组学研究人员和医疗保健专业人员，包括临床科学家、医学微生物学的专门注册员或顾问。由ACSC(https://www.futurelearn.com/search?q=bacterial+genomes)开发的在线未来学习MOOC课程每年吸引成千上万的参与者。到目前为止，约13%的在线参与者来自英国(79000人中有107000人来自英国)。总之，该项目将为临床微生物学领域的专业人员量身定做的新培训资源开发一个框架，使其能够使用数据科学工具来加强英国的医疗保健。该计划强调导师关系和网络建设，将为TTT和直接培训提供可持续、标准化和可扩展的培训模式。

There is a growing need for specialised expertise in data science to support the work of researchers and healthcare professionals including clinical scientists, specialist registrars or consultants in medical microbiology in the UK, as the nature of their work changes and needs to incorporate big data, sequencing and genomics. While curricula in the UK teach some genomics and data analysis and interpretation to these audiences, most training is left to advanced professional courses through postgraduate programmes and other independent training providers. This proposal is motivated by the great demand in training for data science skills for genomics related to infectious pathogens, and a growing need for skilled trainers. Our goal is to enhance training capacity across the UK, able to provide education in Data Science for Pathogen Genomics and Surveillance for healthcare professionals working in the field of clinical microbiology.We plan to achieve this by 1) implementing a series of Train-the-trainer (Tt) courses 2) offering mentorship and encouraging networking and 3) building and publishing freely available training resources. While regular training courses provide individual participants with skills on how to analyse and interpret their own data, TtT approaches apply the concept of forward teaching and equip professionals who are already knowledgeable in pathogen genomics data science with the skills needed to train others.A key focus will be training participants in teaching and facilitation skills. We will also develop a project-based learning approach, where participants will be mentored to build their own training materials. This will be followed by in-person sessions, where they will demonstrate how they will deliver training to others and will receive feedback on their teaching methods. Participants will be supported to deliver training in their research or work environments, through mentorship and networking. By the end of the project, we will publish freely available, ready-to-use training resources for use by trainers in data science for pathogen genomics in the UK. This proposal brings together the expertise of the Centre for Genomic Pathogen Surveillance (CGPS) and the Wellcome Genome Campus Advanced Courses and Scientific Conferences (ACSC), who have previously collaborated in running several courses, including "Train-the-trainer Capacity Building for Genomic Surveillance of AMR in LMICs" (2019, Wellcome Genome Campus). CGPS works to translate the analysis of pathogen spread and AMR research into public health benefit, by the generation of open-access tools for the interpretation of local sequence data in a global context. CGPS has experience in all aspects required to build capacity in genomic AMR surveillance, drawn from running an NIHR Global Health Research Unit, in collaboration with laboratories from Colombia, India, Nigeria and The Philippines. ACSC have over 30 years experience in delivery of training courses for researchers and healthcare professionals. Key courses include Genomics of Clinical Microbiology and Genomics for Clinical Virology, which are primarily targeted at genomics researchers and healthcare professionals including clinical scientists, specialist registrars or consultants in medical microbiology in the UK. Online Future Learn MOOC courses developed by ACSC (https://www.futurelearn.com/search?q=bacterial+genomes) attract tens of thousands of participants every year. To date, ~13% of the online participants are from the UK (10,7k from the UK out of 79k total). In summary, this project will develop a framework for new training resources tailored to professionals in clinical microbiology fields, enabling use of data science tools to enhance healthcare in the UK. Emphasising on mentorship and network building, the programme will provide a sustainable, standardised and scalable training model both for TtT and for direct training.