STRUCTURE & FUNCTION OF CHOLESTEROL ESTERASE

结构

• 批准号: 6119428
• 负责人: JULIAN CHEN
• 金额: --
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6119428
• 关键词: biomaterials; cardiovascular system; enzymes; proteins

Cholesterol esterase is an enzyme that accounts for 4% of total secreted protein by the pancreas. It is responsible for hydrolyzing dietary cholesterol esters into free cholesterol, which can then be absorbed into the bloodstream. When bound to the surface of intestinal cells, cholesterol esterase facilitates the transport of cholesterol across the cell membrane by hydrolysis of these mixed micelles, exposing free cholesterol to the cell membrane. This finding highlights cholesterol esterase as an important enzyme in the cholesterol absorption pathway. We are therefore interested in the enzyme and its complexes with heparin analogs, bile salts, phospholipids and cholesterol esters.

胆固醇酯酶是一种酶，占总量的4%， 胰腺分泌的蛋白质。 它负责水解 膳食胆固醇酯转化为游离胆固醇， 被吸收到血液中 当被束缚在 肠细胞，胆固醇酯酶促进运输 胆固醇通过水解这些混合的细胞膜 胶束，将游离胆固醇暴露于细胞膜。 这 这一发现强调了胆固醇酯酶作为一种重要的酶， 胆固醇吸收途径。 因此，我们对 酶及其与肝素类似物，胆汁盐， 磷脂和胆固醇酯。