STRUCTURAL CHARACTERIZATION OF NICOTINIC ACETYLCHOLINE RECEPTOR

烟碱乙酰胆碱受体的结构表征

• 批准号: 6586623
• 负责人: JULIAN CHEN
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586623
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; minerals; nervous system; proteins; radiography; structural biology

The nicotinic acetylcholine receptor is the best-characterized ligand-gated ion channel, a member of a superfamily of neurotransmitter receptors that also includes receptors for GABA, serotonin and glycine. It is important in mediating communication between neurons. Many mental processes and disorders stem from normal function and defects in this family of receptors, and the structure of this receptor is a key first step toward the design of new drugs and pharmaceuticals. We stand to gain much insight about the structure of membrane proteins, ion channels, and glycoproteins from such a study.

烟碱型乙酰胆碱受体是最有特征的受体。 配体门控离子通道，超家族的成员 神经递质受体，还包括 GABA 受体， 血清素和甘氨酸。 它对于调解沟通很重要 神经元之间。 许多心理过程和障碍源于正常现象 该受体家族的功能和缺陷，以及 该受体是设计新药的关键第一步 药品。 我们将获得更多有关结构的见解 来自此类研究的膜蛋白、离子通道和糖蛋白。