RELEVANCE OF CHEMICALLY INDUCED HEMANGIOSARCOMAS IN B6C3F1 MOUSE

工作概述：假设环氧化物中间体在其中起作用。 在血管瘤发病机制中的作用， 肿瘤抑制基因和原癌基因的改变。 初步 数据显示氯丁二烯诱导的血管瘤 p53蛋白和特异性点突变已在外显子5-8中检测到。 化学诱导的1，3-丁二烯和 正在评估四氟乙烯研究的特定遗传性 P53基因突变 抑癌基因与癌基因 分析将提供关于以下关系的宝贵信息： 致癌物暴露和DNA损伤以及与人类的相关性。

Summary of Work: It is hypothesized that epoxide intermediates play a role in the pathogenesis of hemangiosarcomas by causing genetic alterations in tumor suppressor genes and proto-oncogenes. Preliminary data has shown that chloroprene induced hemangiosarcomas have elevated p53 protein and specific point mutations have been detected in exon 5-8. Chemically induced hemangiosarcomas in 1, 3 butadiene and tetrafluoroethylene studies are being evaluated for specific genetic alterations in the P53 gene. Tumor suppressor gene and oncogene analysis will provide valuable information on the relationship between carcinogen exposure and DNA damage and the relevance to humans.