RELEVANCE OF CHEMICALLY INDUCED HEMANGIOSARCOMAS IN B6C3F1 MOUSE

B6C3F1 小鼠化学诱发血管肉瘤的相关性

• 批准号: 6162145
• 负责人: H L HONG
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162145
• 关键词: angiosarcoma; animal genetic material tag; carcinogen testing; chemical carcinogen; chemical carcinogenesis; gene mutation; laboratory mouse; mutagen testing; mutagens; neoplasm /cancer genetics; oncogenes; tumor suppressor genes

Summary of Work: It is hypothesized that epoxide intermediates play a role in the pathogenesis of hemangiosarcomas by causing genetic alterations in tumor suppressor genes and proto-oncogenes. Preliminary data has shown that chloroprene induced hemangiosarcomas have elevated p53 protein and specific point mutations have been detected in exon 5-8. Chemically induced hemangiosarcomas in 1, 3 butadiene and tetrafluoroethylene studies are being evaluated for specific genetic alterations in the P53 gene. Tumor suppressor gene and oncogene analysis will provide valuable information on the relationship between carcinogen exposure and DNA damage and the relevance to humans.

工作总结：假设环氧化物中间体起到 基因在血管肉瘤发病中的作用 肿瘤抑制基因和原癌基因的改变。初步 数据显示，氯丁二烯诱导的血管肉瘤 在外显子5-8已检测到P53蛋白和特异点突变。 1，3丁二烯和1，3丁二烯化学诱导血管肉瘤 四氟乙烯的研究正在进行评估，以确定特定的基因 P53基因的改变。抑癌基因与癌基因 分析将提供关于两者之间关系的宝贵信息 致癌物暴露和DNA损伤及其与人类的相关性。