RELEVANCE OF CHEMICALLY INDUCED HEMANGIOSARCOMAS IN B6C3F1 MOUSE

工作总结：假设环氧化物中间体起着 遗传因素在血管肉瘤发病机制中的作用 抑癌基因和原癌基因的改变。 初步 数据显示，氯丁二烯诱发的血管肉瘤升高 在外显子5-8中检测到p53蛋白和特异性点突变。 1、3 丁二烯和 1、3 丁二烯中化学诱导的血管肉瘤 正在评估四氟乙烯研究的特定遗传 P53 基因的改变。 抑癌基因和癌基因 分析将提供有关之间关系的有价值的信息 致癌物暴露和 DNA 损伤以及与人类的相关性。

Summary of Work: It is hypothesized that epoxide intermediates play a role in the pathogenesis of hemangiosarcomas by causing genetic alterations in tumor suppressor genes and proto-oncogenes. Preliminary data has shown that chloroprene induced hemangiosarcomas have elevated p53 protein and specific point mutations have been detected in exon 5-8. Chemically induced hemangiosarcomas in 1, 3 butadiene and tetrafluoroethylene studies are being evaluated for specific genetic alterations in the P53 gene. Tumor suppressor gene and oncogene analysis will provide valuable information on the relationship between carcinogen exposure and DNA damage and the relevance to humans.