PESTICIDE AND FERTILIZER MIXTURE STUDY

人类接触化学品很少仅限于一种化学品。 最近对农业地区地下水污染的关注， 引导NTP发起了一项农药/肥料毒理学研究 化学混合物，根据已确认的地下水污染， 加州和爱荷华州。在进行长期毒性研究的同时 对合同、特定骨髓毒性和骨髓残留影响的影响 考察在暴露于以下物质的小鼠中监测骨髓参数： 0、1X、1 OX、100 X的化学混合物II或III饮用水， 15周一些小鼠在停止给药后恢复8周。 化学治疗，然后接受全身照射200拉德两次， 8-周间隔。还进行了血液学和组织病理学检查。 执行。

Human exposure to chemicals is rarely limited to one single chemical. Recent concern about groundwater contamination in agricultural areas has led the NTP To initiate a study of the toxicology of pesticide/fertilizer chemical mixtures which are based on confirmed groundwater contamination in California and Iowa. While the long-term toxicity studies were being done on contract, specific myelotoxicity and residual effects of bone marrow were investigated. Bone marrow parameters were monitored in mice exposed to 0, 1X, 1OX, and 100X of chemical mixture II or III drinking water for 3 to 15 weeks. Some mice were allowed to recover for 8 weeks after cessation of chemical treatment, then Received whole body irradiation 200 rads twice at 8-week intervals. Examinations of hematology and histopathology were also performed.