RAS ONCOGENE MUTATIONS IN TETRAFLUOROETHYLENE LIVER

四氟乙烯肝脏中的 RAS 癌基因突变

• 批准号: 6162127
• 负责人: H L HONG
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162127
• 关键词: animal genetic material tag; chemical carcinogen; chemical carcinogenesis; environmental toxicology; fluorocarbon polymers; gene mutation; hepatocellular carcinoma; laboratory mouse; longitudinal animal study; nucleic acid sequence; oncogenes

Summary of Work: A low frequency (155, 9/59) of H-ras codon 61 mutations was detected in hepatocellular neoplasms when compared to the higher frequency (59% of this study and 56% of historical data) in spontaneous liver neoplasms. There was no difference in the mutation frequency or spectrum among exposure groups or between benign and malignant heopatocellular neoplasms. K-ras mutations at codons as 12, 13, and 61 and H-ras mutations at codon 117 were not detected in hepatocellular newplasms. The frequency to be similar to those identified in liver neoplasms from the structurally related chemical tetrachloroethylene (TCE). These data suggest that FGE-induced heptocellular neoplasms and newplasms and neoplasms from structurally related chemical classes most likely develop by pathway ndependent of H- and K-ras proto-oncogene activation. The manuscript is in preparation.

工作总结：H-ras密码子61突变频率较低（155，9/59） 在肝细胞肿瘤中检测到， 自发性研究的频率（本研究的59%和历史数据的56%） 肝肿瘤 在突变频率或 暴露组之间或良性和恶性之间的光谱 肝细胞肿瘤密码子12、13和61处的K-ras突变 肝细胞癌中未检测到H-ras基因第117位密码子突变 新来的频率与肝脏中确定的频率相似 结构相关的化学物质四氯乙烯引起的肿瘤 （TCE）。 这些数据表明，FGE诱导的肝细胞肿瘤， 从结构上相关的化学类别中分离出来的新生物和肿瘤 可能是通过H-和K-ras原癌基因途径依赖性发展 activation. 手稿正在准备中。