THE EFFECT OF SODIUM FLUORIDE ADMINISTRATION ON RADIATION INDUCED OSTEOSARCOMAS

人们对氟化钠的研究非常感兴趣， 由NTP完成。 然而，发生了可疑的致瘤反应， 在雄性大鼠中，但在雌性大鼠或小鼠中未观察到反应。 男性 大鼠似乎对潜在的致癌作用更敏感， NaF比雌性大鼠或小鼠。 因为辐射可以改变， 各种骨肉瘤率，这项随访研究将是一个明显的手段， 评估NaF的可能促进活性。 目标是 确定放射诱导的大鼠骨肉瘤是否受 饮用水中的氟化钠。 雄性F344大鼠以0 和275 ppm的饮用水，每天10个月后照射。 用~（137）Cs照射大鼠右后肢（3000拉德） 源头 在2年研究结束时， 动物将被人道地杀死，组织收集，固定，然后切片 并进行组织病理学评价。

There is tremendous interest in the Sodium Fluoride study that was just completed by the NTP. However, an equivocal tumorigenic response occurred in male rats, but no response was observed in female rats or mice. Male rats appear to be more sensitive to the potential carcinogenic effects of NaF than female rats or mice. Since irradiation can be altered to produce, various osteosarcoma rates, this follow-up study would be an obvious means of evaluating the possible promoting activity of NaF. The objective is to determine whether radiation induced osteosarcoma in rats is influenced by exposure to NaF in the drinking water. Male F344 rats are given NaF at 0 and 275 ppm in drinking water daily for 10 months following irradiation. Irradiation (3000 rads) subjects to the right rear limb of rat with 137 Cs source. At the end of the 2-year duration of the study, the surviving animals will be humanely killed, tissues collected, fixed, and then slides made and evaluated histopathologically.