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COEXISTENCE OF PEPTIDES AND NEUROTRANSMITTERS--CALRETININ IN NEUROGLIOMA

COEXISTENCE OF PEPTIDES AND NEUROTRANSMITTERS--CALRETININ IN NEUROGLIOMA
神经胶质瘤中肽与神经递质的共存——钙维A蛋白
批准号：
6162825
负责人：
D M JACOBOWITZ
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6162825
关键词：
RNase protection assay brain cell calcium binding protein cell proliferation immunocytochemistry in situ hybridization neoplastic cell culture for noncancer research neurochemistry neuropeptides neurotransmitter biosynthesis neurotransmitters

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英文摘要
We have been studying neuroglioma brain cancer cells that grow in culture. We have found, by immunohistochemistry, that calretinin is present in the neuroglioma cells. By gel electrophoresis and immunoblotting, we have also observed a positive band of both calretinin and calbindin. This would suggest that both these calcium binding proteins coexist in these neuroglioma cells. By ribonuclease protection assay we have revealed the presence of calretinin mRNA. We speculate that calretinin may be involved in cell proliferation of these cancer cells.
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LOCALIZATION AND CHARACTERIZATION OF BRAIN NEUROPEPTIDES
STUDIES OF CALRETININ IN PERIPHERAL ORGANS AND CELLS
COEXISTENCE OF PEPTIDES AND NEUROTRANSMITTERS
AUTOIMMUNE ASPECTS OF DISEASE
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