FOURIER AND SPLINE BASED RECONSTRUCTIONS IN HELICAL CT

螺旋 CT 中基于傅立叶和样条的重建

• 批准号: 6087135
• 负责人: XIAOCHUAN PAN
• 金额: $ 22.05万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6087135
• 关键词: bioimaging /biomedical imaging; computed axial tomography; human data; image processing; mathematics; method development; phantom model

DESCRIPTION (Adapted from Applicant's Abstract): The broad objective of the proposed research is to develop, implement, and evaluate accurate and efficient approaches to image reconstruction in single- and multi-slice helical computed tomography (CT). The numerous advantages of helical CT, such as its high volume-scanning speed, have allowed it to displace conventional CT as the test of choice in many clinical situations and allowed for the development of new imaging protocols that were not even possible with conventional CT. The investigators' preliminary theoretical and empirical studies strongly suggest that the proposed reconstruction approaches preserve all of the inherent advantages of helical CT available when existing reconstruction approaches are used while improving physical characteristics such as aliasing response, longitudinal resolution, and noise properties, with little or no additional computation burden. Such improvements have a number of clinical implications: (a) Improved longitudinal resolution can enhance the diagnostic accuracy of focal pathologic abnormalities such as lung nodules. (b) The ability of the approaches to reduce or control image noise levels in optimal ways can be exploited either for improving image quality for a given patient radiation exposure or for reducing patient exposure while holding image quality constant. Reduced exposure also reduces the burden on overworked x-ray tubes. (c) The approaches can yield reconstructed volumes that have more isotropic noise and resolution properties than can existing approaches, which would improve the quality of multiplanar reformats generated form these volumes. (d) Most significantly, the proposed approaches would allow clinicians to trade off the resolution and noise improvements for improved temporal resolution. This would particularly benefit CT angiography, where improved temporal resolution translates directly into improved bolus tracking and thus improved image contrast. The specific aims of the proposal are: (1) development of a Fourier-based longitudinal interpolation approach for helical CT; (2) development of a spline-based longitudinal interpolation approach for helical CT; (3) development of optimal methods for the exploitation of redundant fan-beam information; (4) development and evaluation of novel fan-beam reconstruction algorithms; and (5) evaluation of the physical characteristics and clinical-task performance of all of the proposed approaches; with comparison to existing approaches.

描述（改编自申请人的摘要）：该项目的总体目标 拟议的研究是为了开发、实施和评估准确有效的 单层和多层螺旋计算图像重建方法 断层扫描（CT）。螺旋CT的众多优点，例如它的高 体积扫描速度，使其能够取代传统 CT 作为测试 在许多临床情况下的选择，并允许开发新的 传统 CT 甚至无法实现的成像方案。这 研究人员的初步理论和实证研究强烈表明 拟议的重建方法保留了所有固有的 当现有重建方法无法使用时，螺旋 CT 的优势 在改善物理特性（例如混叠响应）的同时使用， 纵向分辨率和噪声特性，很少或没有额外的 计算负担。这些改进具有许多临床意义： (a) 提高纵向分辨率可以提高诊断准确性 局灶性病理异常，例如肺结节。 (b) 的能力 以最佳方式降低或控制图像噪声水平的方法可以是 用于提高给定患者辐射的图像质量 曝光或减少患者曝光，同时保持图像质量恒定。 减少曝光也减轻了过度劳累的 X 射线管的负担。 （三） 方法可以产生具有更多各向同性噪声和 分辨率特性优于现有方法，这将改善 从这些卷生成的多平面重新格式化的质量。 (d) 大多数 值得注意的是，所提出的方法将允许临床医生权衡 分辨率和噪声的改进可提高时间分辨率。这会 尤其有利于 CT 血管造影，可提高时间分辨率 直接转化为改进的推注跟踪，从而改进图像 对比。该提案的具体目标是：（1）开发 基于傅里叶的螺旋CT纵向插值方法； (2) 基于样条的螺旋纵向插补方法的开发 CT； (3) 开发冗余资源利用的最优方法 扇形束信息； (4)新型扇形梁的研制与评价 重建算法； (5)物理特性的评价 以及所有提议方法的临床任务表现；和 与现有方法的比较。