PDGF GENE REGULATION BY VITAMINS A & D IN ALVEOLIZATION
PDGF GENE REGULATION BY VITAMINS A & D IN ALVEOLIZATION
批准号:
6042829
负责人:
David M Kaetzel
金额:
$21.6万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-09-29 至 2004-07-31
关键词:
cell line cell proliferation dexamethasone fibroblasts gene expression gene targeting genetic promoter element genetic regulation genetic transcription genetically modified animals growth factor receptors histogenesis laboratory rat lung alveolus platelet derived growth factor respiratory function retinoids tissue /cell culture vitamin D
中文摘要
研究者建议评估RA、VitD、 类似物,
和地塞米松单独或组合对细胞增殖的影响
PDGFs及其受体在体外肺发育过程中的表达
(Aim 1)和体内(目的2)。这将包括对以下方面的影响进行评价:
这些治疗对肺泡形成和肺功能的影响(目的2)。了一种
将进行调节PDGF表达的机制的分析,
为了表征顺式和反式元件,
肺发育过程中PDGF-A链启动子的转录激活
(Aims 3和4)。
英文摘要
The investigator proposes to assess the effect of RA, VitD, analogs,
and dexamethasone individually or in combination on cell proliferation
and expression of PDGFs and their receptors during lung development in vitro
(Aim 1) and in vivo (Aim 2). This will include an evaluation of the effect of
these treatments on alveolar formation and on lung function (Aim 2). Then, an
analysis of the mechanisms regulating PDGF expression will be performed, aiming
to characterize cis and trans elements potentially important on mediating
transcriptional activation of the PDGF-A chain promoter during lung development
(Aims 3 and 4).
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Suppression of Melanoma Initiation and Progression by NM23-H1
-
批准号:8542790
-
项目类别:
-
资助金额:$45.57万
-
财政年份:2012
-
负责人:David M Kaetzel
-
依托单位:
Suppression of Melanoma Initiation and Progression by NM23-H1
-
批准号:9079412
-
项目类别:
-
资助金额:$37.19万
-
财政年份:2012
-
负责人:David M Kaetzel
-
依托单位:
Suppression of Melanoma Initiation and Progression by NM23-H1
-
批准号:8686773
-
项目类别:
-
资助金额:$36.13万
-
财政年份:2012
-
负责人:David M Kaetzel
-
依托单位:
Suppression of Melanoma Initiation and Progression by NM23-H1
-
批准号:9275063
-
项目类别:
-
资助金额:$5.01万
-
财政年份:2012
-
负责人:David M Kaetzel
-
依托单位:
Suppression of Melanoma Initiation and Progression by NM23-H1
-
批准号:9040526
-
项目类别:
-
资助金额:$5.01万
-
财政年份:2012
-
负责人:David M Kaetzel
-
依托单位:
Suppression of Melanoma Initiation and Progression by NM23-H1
-
批准号:8402060
-
项目类别:
-
资助金额:$49.81万
-
财政年份:2012
-
负责人:David M Kaetzel
-
依托单位:
PDGF GENE REGULATION BY VITAMINS A & D IN ALVEOLIZATION
-
批准号:6390400
-
项目类别:
-
资助金额:$22.22万
-
财政年份:2000
-
负责人:David M Kaetzel
-
依托单位:
PDGF GENE REGULATION BY VITAMINS A & D IN ALVEOLIZATION
-
批准号:6610954
-
项目类别:
-
资助金额:$23.57万
-
财政年份:2000
-
负责人:David M Kaetzel
-
依托单位:
PDGF GENE REGULATION BY VITAMINS A & D IN ALVEOLIZATION
-
批准号:6527361
-
项目类别:
-
资助金额:$22.89万
-
财政年份:2000
-
负责人:David M Kaetzel
-
依托单位:
NM23 PROTEINS AND MECHANISMS OF PDGF A CHAIN SILENCING
-
批准号:6377515
-
项目类别:
-
资助金额:$20.68万
-
财政年份:1999
-
负责人:David M Kaetzel
-
依托单位:
Molecular Mechanisms of Metastasis Suppression by NM23
-
批准号:7472332
-
项目类别:
-
资助金额:$20.39万
-
财政年份:1999
-
负责人:David M Kaetzel
-
依托单位:
Molecular Mechanisms of Metastasis Suppression by NM23
-
批准号:7290453
-
项目类别:
-
资助金额:$20.46万
-
财政年份:1999
-
负责人:David M Kaetzel
-
依托单位:
NM23 PROTEINS AND MECHANISMS OF PDGF A CHAIN SILENCING
-
批准号:6514195
-
项目类别:
-
资助金额:$21.3万
-
财政年份:1999
-
负责人:David M Kaetzel
-
依托单位:
Molecular Mechanisms of Metastasis Suppression by NM23
-
批准号:7645828
-
项目类别:
-
资助金额:$27.82万
-
财政年份:1999
-
负责人:David M Kaetzel
-
依托单位:
NM23 PROTEINS AND MECHANISMS OF PDGF A CHAIN SILENCING
-
批准号:6174155
-
项目类别:
-
资助金额:$20.08万
-
财政年份:1999
-
负责人:David M Kaetzel
-
依托单位:
Molecular Mechanisms of Metastasis Suppression by NM23
-
批准号:7196154
-
项目类别:
-
资助金额:$20.84万
-
财政年份:1999
-
负责人:David M Kaetzel
-
依托单位:
Molecular Mechanisms of Metastasis Suppression by NM23
-
批准号:7899765
-
项目类别:
-
资助金额:$20.39万
-
财政年份:1999
-
负责人:David M Kaetzel
-
依托单位:
NM23 PROTEINS AND MECHANISMS OF PDGF A CHAIN SILENCING
-
批准号:6012127
-
项目类别:
-
资助金额:$17.7万
-
财政年份:1999
-
负责人:David M Kaetzel
-
依托单位:
NM23 PROTEINS AND MECHANISMS OF PDGF A CHAIN SILENCING
-
批准号:6633520
-
项目类别:
-
资助金额:$21.94万
-
财政年份:1999
-
负责人:David M Kaetzel
-
依托单位:
PDGF GENE TRANSCRIPTION IN RENAL EPITHELIAL CELLS
-
批准号:2391452
-
项目类别:
-
资助金额:$10.29万
-
财政年份:1993
-
负责人:David M Kaetzel
-
依托单位:
海外基金