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PDGF GENE REGULATION BY VITAMINS A & D IN ALVEOLIZATION

PDGF GENE REGULATION BY VITAMINS A & D IN ALVEOLIZATION
维生素 A 对 PDGF 基因的调节
批准号:
6527361
负责人:
David M Kaetzel
金额:
$22.89万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-09-29 至 2004-07-31

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中文摘要
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英文摘要
The investigator proposes to assess the effect of RA, VitD, analogs, and dexamethasone individually or in combination on cell proliferation and expression of PDGFs and their receptors during lung development in vitro (Aim 1) and in vivo (Aim 2). This will include an evaluation of the effect of these treatments on alveolar formation and on lung function (Aim 2). Then, an analysis of the mechanisms regulating PDGF expression will be performed, aiming to characterize cis and trans elements potentially important on mediating transcriptional activation of the PDGF-A chain promoter during lung development (Aims 3 and 4).
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Suppression of Melanoma Initiation and Progression by NM23-H1
  • 批准号:
    8542790
  • 项目类别:
  • 资助金额:
    $45.57万
  • 财政年份:
    2012
  • 负责人:
    David M Kaetzel
  • 依托单位:
Suppression of Melanoma Initiation and Progression by NM23-H1
  • 批准号:
    9079412
  • 项目类别:
  • 资助金额:
    $37.19万
  • 财政年份:
    2012
  • 负责人:
    David M Kaetzel
  • 依托单位:
Suppression of Melanoma Initiation and Progression by NM23-H1
  • 批准号:
    8686773
  • 项目类别:
  • 资助金额:
    $36.13万
  • 财政年份:
    2012
  • 负责人:
    David M Kaetzel
  • 依托单位:
Suppression of Melanoma Initiation and Progression by NM23-H1
  • 批准号:
    9275063
  • 项目类别:
  • 资助金额:
    $5.01万
  • 财政年份:
    2012
  • 负责人:
    David M Kaetzel
  • 依托单位:
海外基金