CCCWFU RESEARCH BASE GRANT

CCCWFU研究基地资助

• 批准号: 6174081
• 负责人: EDWARD G SHAW
• 金额: $ 40.96万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-07 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6174081
• 关键词: antineoplastics; behavioral /social science research tag; cancer prevention; cancer rehabilitation /care; chemoprevention; clinical research; clinical trials; community health services; cooperative study; drug administration routes; health services research tag; human subject; human therapy evaluation; male; medical outreach /case finding; medical rehabilitation related tag; metastasis; neoplasm /cancer chemotherapy; neoplasm /cancer education; neoplasm /cancer therapy; primary care physician; prostate neoplasms; vitamin D; vitamin therapy

This Research Base application describes the administrative structure and array of cancer prevention and control studies and cancer treatment studies that will allow the Comprehensive Cancer Center of Wake Forest University (CCCWFU) to be a Research Base for four Community Clinical Oncology Programs (CCOP's) including the Southeast Cancer Control Consortium, Upstate Carolina CCOP, Greenville (SC) CCOP, and Medical College of Virginia Minority CCOP. In addition, East Carolina University (ECU) will be a non- CCOP participant in the Research Base. Including CCCWFU and ECU patients, the Research Base will serve patients from seven states (NC, SC, VA, WV, KY, TN, and GA), which encompasses 20 community and 2 university Cancer Centers. The population base in this large geographic region is in excess of 10 million people, including communities with up to 60 percent minorities, mainly African-Americans. The cancer prevention and control research will focus on symptom management and primary and secondary chemoprevention studies. The cancer treatment research will focus on novel combinations or routes of administration of chemotherapeutic agents in a variety of metastatic solid tumors and vitamin D as an anti-cancer and differentiating agent in biochemically recurrent prostate cancer (an example of "bench" research translating directly into the community setting). The Principal Investigator of the grant will be Edward G. Shaw, M.D., Associate Director of Clinical Research for the CCCWFU. The Co-Investigators and members of the Steering Committee give the scientific leadership of the Research Base broad multidisciplinary representation including those from Public Health Sciences, Hematology/Oncology, Radiation Oncology, Surgical Oncology, and Cancer Biology. In summary, the CCCWFU Research Base Grant will serve the CCOP's of the Southeast United States and further the Cancer Center's outreach and impact on its local and regional communities, which include significant minority and underserved populations, by reducing cancer incidence, improving treatment efficacy, minimizing treatment morbidity, and improving the quality of care.

该研究基地申请描述了癌症预防和控制研究以及癌症治疗研究的管理结构和阵列，这些研究将使维克森林大学综合癌症中心（CCCWFU）成为四个社区临床肿瘤学项目（CCOP）的研究基地，包括东南癌症控制联盟、北卡罗莱纳CCOP、格林维尔（SC）CCOP和弗吉尼亚少数民族医学院CCOP。 此外，东卡罗莱纳大学（ECU）将是研究基地的非CCOP参与者。 包括CCCWFU和ECU患者，研究基地将为来自七个州（NC，SC，VA，WV，KY，TN和GA）的患者提供服务，其中包括20个社区和2个大学癌症中心。 这个庞大地理区域的人口基数超过1000万人，其中包括少数族裔比例高达60%的社区，其中主要是非裔美国人。 癌症预防和控制研究将侧重于症状管理和初级和二级化学预防研究。 癌症治疗研究将侧重于化疗药物在各种转移性实体瘤中的新型组合或给药途径，以及维生素D作为抗癌和分化剂在生化复发性前列腺癌中的应用（“实验室”研究的一个例子直接转化为社区环境）。 是项研究的主要研究员为爱德华·G·肖，医学博士，CCCWFU临床研究副主任。 指导委员会的共同研究者和成员给予研究基地广泛的多学科代表性的科学领导，包括公共卫生科学，血液学/肿瘤学，放射肿瘤学，外科肿瘤学和癌症生物学。 总之，CCCWFU研究基地赠款将为美国东南部的CCOP提供服务，并通过降低癌症发病率，提高治疗效果，最大限度地减少治疗发病率和提高护理质量，进一步推动癌症中心对当地和区域社区的推广和影响，其中包括重要的少数民族和服务不足的人群。