CCCWFU Research Base Grant

CCCWFU研究基地资助

• 批准号: 7127131
• 负责人: EDWARD G SHAW
• 金额: $ 28.36万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-07 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7127131
• 关键词: alternative medicine; brain neoplasms; cancer prevention; cancer rehabilitation /care; chemoprevention; clinical research; clinical trials; cooperative study; experimental designs; human subject; human therapy evaluation; lung neoplasms; medical outreach /case finding; neoplasm /cancer education; neoplasm /cancer therapy; pancreas neoplasms; patient oriented research; psychological aspect of cancer; quality of life

DESCRIPTION (provided by applicant): The Comprehensive Cancer Center of Wake Forest University (CCCWFU) Community Clinical Oncology Program (CCOP) Research Base was funded in 9/99 (retroactive to 6/99) for three years. This application describes the administrative structure, including safety and monitoring procedures and clinical research activities of the Research Base for its five-year competitive renewal as a control/treatment CCOP Research Base. Participants in the Research Base include three CCOPs (Southeast Cancer Control Consortium, Winston-Salem, NC; Upstate Carolina CCOP, Spartanburg, SC; Greenville CCOP, Greenville SC) and four non-CCOP Prevention Members (East Carolina University, Greenville, NC; High Point Regional Health System, High Point, NC; InterCommunity Cancer Center, Rome, GA; WakeMed System, Cary, NC. The geographic region covered by these three CCOPs and four Prevention Members includes seven states (NC, SC, VA, WV, KY, TN, GA) with a population of approximately 12 million people, one-quarter of whom are minorities (60% minorities in coastal NC communities), served by 28 cancer centers. It is anticipated that an additional 3-6 CCOPs and Minority-Based CCOPs will join the CCCWFU CCOP Research Base by 12/01. Active and developing clinical trials of the Research Base are described in the application. In cancer control, there are 4 active and 13 developing studies, focusing on the following areas: complimentary and alternative medicine, symptom management, and quality of life, particularly in the setting of cancer related fatigue, anorexia/weight loss, depression, hot flashes, cognition and chemoprevention. In cancer treatment, there are 6 active and 7 developing studies, focusing on complementary, alternative, and conventional therapies primarily in lung, pancreas, and brain cancer. The spectrum of clinical research studies offered by the CCCWFU CCOP Research Base is complementary to, rather than competitive with, the cancer control/treatment protocols offered by the Cooperative Group Research Bases. Under the direction of Principal Investigator Edward G. Shaw, M.D., the Clinical Research Management administrative structure of the CCCWFU, and key leadership from the CCCWFU, CCOPs, and Prevention Members, the CCCWFU CCOP Research Base is fulfilling its primary goal of providing state-of-the-art intervention oriented clinical research studies in cancer prevention/control to CCOPs and patients (including minorities) in the Southeast United States.

描述（由申请人提供）： 维克森林大学综合癌症中心（CCCWFU）社区临床肿瘤学计划（CCOP）研究基地于9/99（追溯至6/99）资助三年。本申请描述了管理结构，包括该研究基地作为控制/治疗 CCOP 研究基地的五年竞争更新的安全和监测程序以及临床研究活动。研究基地的参与者包括三个 CCOP（东南癌症控制联盟，北卡罗来纳州温斯顿塞勒姆；北卡罗莱纳州北部 CCOP，南卡罗来纳州斯巴达堡；格林维尔 CCOP，南卡罗来纳州格林维尔）和四个非 CCOP 预防成员（东卡罗来纳大学，北卡罗来纳州格林维尔；海波因特区域卫生系统，北卡罗来纳州海波因特；社区间癌症中心，罗马，佐治亚州；WakeMed 系统，北卡罗来纳州卡里。 这三个 CCOP 和四个预防成员所覆盖的地理区域包括七个州（北卡罗来纳州、南卡罗来纳州、 弗吉尼亚州、西弗吉尼亚州、肯塔基州、田纳西州、佐治亚州），人口约 1200 万，其中四分之一是少数族裔（北卡罗来纳州沿海社区有 60% 为少数族裔），由 28 个癌症中心提供服务。预计到 12 月 1 日，将有另外 3-6 个 CCOP 和少数族裔 CCOP 加入 CCCWFU CCOP 研究基地。申请中描述了研究基地正在开展的临床试验。在癌症控制方面，有 4 种处于活跃状态，13 种处于发展中状态 研究重点关注以下领域：补充和替代医学、症状管理和生活质量，特别是在癌症相关的疲劳、厌食/体重减轻、抑郁、潮热、认知和化学预防方面。在癌症治疗方面，有 6 项正在进行的研究和 7 项正在开发的研究，重点关注主要针对肺癌、胰腺癌和脑癌的补充疗法、替代疗法和传统疗法。的频谱 CCCWFU CCOP 研究基地提供的临床研究是对合作组研究基地提供的癌症控制/治疗方案的补充，而不是竞争。在首席研究员 Edward G. Shaw 医学博士的指导下，CCCWFU 的临床研究管理管理结构和主要领导层 来自 CCCWFU、CCOP 和预防成员、CCCWFU CCOP 研究基地 正在实现其主要目标，即为美国东南部的 CCOP 和患者（包括少数族裔）提供最先进的以干预为导向的癌症预防/控制临床研究。