Comprehensive Cancer Center of Wake Forest University CCOP Research Base

维克森林大学综合癌症中心CCOP研究基地

基本信息

批准号：
7663743
负责人：
EDWARD G SHAW
金额：
$ 204.83万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-09-07 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7663743
关键词：
Adolescent Alternative Therapies Anorexia Area Behavioral Biological Factors Body Weight decreased Botanicals Cancer Center Cancer Control Cardiotoxicity Chemoprevention Clinical Oncology Clinical Research Clinical Trials Communities Community Clinical Oncology Program Comprehensive Cancer Center of Wake Forest University Controlled Clinical Trials Controlled Study Cystitis Dermatitis Division of Cancer Prevention Double-Blind Method Educational Intervention Elderly Esophagitis Fatigue Fish Oils Fruit and Vegetable Extracts Funding Hot flushes Incidence Infection Malignant Neoplasms Minority Minority Groups Mission Moods Mucositis National Cancer Institute Nursing Research Patients Phase Phase III Clinical Trials Physicians Placebo Control Population Prevention Prevention Research Quality of life Radiation Randomized Research Sex Functioning Staging Steroids Symptoms Tobacco Use Cessation Toxic effect Universities Vitamin D Weight Weight Gain Woman analog base cancer prevention cognitive function diet and exercise dietary supplements enteritis forest improved innovation member oncology open label prevent programs symptom management

项目摘要

DESCRIPTION (provided by applicant): This application represents the second competing renewal of the Comprehensive Cancer Center of Wake Forest University (CCCWFU) Community Clinical Oncology Program (CCOP) Research Base. At present, the Research Base has 11 participating CCOPs (including one Minority-Based CCOP) and 5 Prevention Members, with an additional eight CCOPs (including four MB CCOPs) who are in various stages of joining. The CCCWFU CCOP Research Base has three Specific Aims: o Specific Aim 1: To reduce cancer incidence and improve quality of life by providing high-quality cancer prevention and control clinical trials for the physicians, research nurses, clinical research professionals, and patients from participating CCOPs, Minority-Based CCOPs, and Prevention Members. o Specific Aim 2: To prevent or reduce the symptoms of cancer and its treatments by utilizing conventional pharmacologic agents, botanical and natural products, complementary and alternative therapies, and behavioral and/or educational interventions in open-label Phase II and randomized ( placebo-controlled) ( double-blind) Phase III clinical trials. o Specific Aim 3: To increase recruitment and retention on CCCWFU CCOP Research Base clinical trials, with a particular emphasis on under-represented populations including racial and ethnic minorities, women, adolescents, and the elderly. Cancer Control studies focus on symptom management (i.e., the symptoms of cancer and its treatments), which is divided into the areas of symptom prevention and symptom treatment. Symptom management research themes include cardiotoxicity, cognitive function and mood, fatigue, hot flashes, infections, the radiation-induced "-itises" (cystitis, dermatitis, enteritis, esophagitis, and mucositis), sexual function, steroid toxicity, tobacco cessation, and weight-related issues (anorexia and weight loss; diet, exercise, and weight gain). Cancer prevention research is focused on primary and secondary chemoprevention studies utilizing dietary supplements as well as botanical and natural products, including fruit and vegetable extracts, vitamin D and its analogues, and fish oil.

描述（由申请人提供）：此申请代表了Wake Forest University综合癌症中心（CCCWFU）社区临床肿瘤学计划（CCOP）研究基础的第二次竞争更新。目前，研究基础有11个参与的CCOP（包括一名基于少数民族的CCOP）和5名预防成员，另外有8个CCOP（包括4个MB CCOP），他们处于加入的各个阶段。 CCCWFU CCOP研究基础具有三个特定的目的：o特定目的1：通过为医生，研究护士，临床研究专业人员以及参与CCOPS，基于少数民族的CCOPS和预防成员提供高质量的癌症预防和控制临床试验，以减少癌症的发生和改善生活质量。 o具体目的2：通过利用常规药理剂，植物和天然产物，互补和替代疗法，以及在开放标签的II期以及随机（安慰剂控制）（双盲）III期临床试验中，以防止或减轻癌症及其治疗的症状。 o具体目标3：增加对CCCWFU CCOP研究基础临床试验的招聘和保留，特别着重于代表性不足的人群，包括种族和少数民族，妇女，青少年和老年人。癌症控制研究的重点是症状管理（即癌症及其治疗的症状），该研究分为预防症状和症状治疗区域。症状管理研究主题包括心脏毒性，认知功能和情绪，疲劳，热闪光，感染，辐射引起的“ ISISIS”（膀胱炎，皮炎，肠炎，肠炎，食管炎和粘膜炎），性功能，固醇毒性，固醇毒性，毒品毒性，毒品凝结和体重降低和体重降低和体重降低和减肥；癌症预防研究的重点是利用饮食补充剂以及植物和天然产物（包括水果和蔬菜提取物，维生素D及其类似物以及鱼油）的初级和继发性化学预防研究。