Comprehensive Cancer Center of Wake Forest University CCOP Research Base

描述（由申请人提供）：本申请代表维克森林大学（CCCWFU）社区临床肿瘤学项目（CCOP）研究基地综合癌症中心的第二次竞争性更新。目前，研究基地有11名参与CCOP（包括一名基于少数群体的CCOP）和5名预防成员，另有8名CCOP（包括4名处于不同加入阶段的MB CCOP）。CCCWFU CCOP研究基地有三个具体目标：o具体目标1：为参加CCOP的医生、研究护士、临床研究专业人员和患者、少数民族CCOP和预防成员提供高质量的癌症预防和控制临床试验，以降低癌症发病率，提高生活质量。o具体目标2：在开放标签II期和随机（安慰剂对照）（双盲）III期临床试验中，通过使用常规药物、植物和天然产品、补充和替代疗法以及行为和/或教育干预来预防或减轻癌症症状及其治疗。具体目标3：增加CCCWFU CCOP研究基地临床试验的招募和保留，特别强调代表性不足的人群，包括种族和少数民族，妇女，青少年和老年人。癌症控制研究侧重于症状管理（即，癌症的症状及其治疗），分为症状预防和症状治疗领域。症状管理研究主题包括心脏毒性、认知功能和情绪、疲劳、潮热、感染、辐射诱导的“炎症”（膀胱炎、皮炎、肠炎、食管炎和粘膜炎）、性功能、类固醇毒性、戒烟和体重相关问题（厌食和体重减轻;饮食、运动和体重增加）。癌症预防研究的重点是利用膳食补充剂以及植物和天然产品（包括水果和蔬菜提取物、维生素D及其类似物和鱼油）进行初级和二级化学预防研究。

DESCRIPTION (provided by applicant): This application represents the second competing renewal of the Comprehensive Cancer Center of Wake Forest University (CCCWFU) Community Clinical Oncology Program (CCOP) Research Base. At present, the Research Base has 11 participating CCOPs (including one Minority-Based CCOP) and 5 Prevention Members, with an additional eight CCOPs (including four MB CCOPs) who are in various stages of joining. The CCCWFU CCOP Research Base has three Specific Aims: o Specific Aim 1: To reduce cancer incidence and improve quality of life by providing high-quality cancer prevention and control clinical trials for the physicians, research nurses, clinical research professionals, and patients from participating CCOPs, Minority-Based CCOPs, and Prevention Members. o Specific Aim 2: To prevent or reduce the symptoms of cancer and its treatments by utilizing conventional pharmacologic agents, botanical and natural products, complementary and alternative therapies, and behavioral and/or educational interventions in open-label Phase II and randomized ( placebo-controlled) ( double-blind) Phase III clinical trials. o Specific Aim 3: To increase recruitment and retention on CCCWFU CCOP Research Base clinical trials, with a particular emphasis on under-represented populations including racial and ethnic minorities, women, adolescents, and the elderly. Cancer Control studies focus on symptom management (i.e., the symptoms of cancer and its treatments), which is divided into the areas of symptom prevention and symptom treatment. Symptom management research themes include cardiotoxicity, cognitive function and mood, fatigue, hot flashes, infections, the radiation-induced "-itises" (cystitis, dermatitis, enteritis, esophagitis, and mucositis), sexual function, steroid toxicity, tobacco cessation, and weight-related issues (anorexia and weight loss; diet, exercise, and weight gain). Cancer prevention research is focused on primary and secondary chemoprevention studies utilizing dietary supplements as well as botanical and natural products, including fruit and vegetable extracts, vitamin D and its analogues, and fish oil.