Comprehensive Cancer Center of Wake Forest University CCOP Research Base

描述(由申请人提供)：本申请是维克森林大学(CCCWFU)社区临床肿瘤学项目(CCOP)研究基地第二次竞争性更新综合癌症中心。目前，研究基地有11名参与的社区合作伙伴(包括1名以少数群体为基础的社区合作伙伴)和5名预防成员，另外还有8名社区合作伙伴(包括4名甲基溴社区合作伙伴)正处于加入的不同阶段。CCCWFU CCOP研究基地有三个具体目标：o具体目标1：通过为医生、研究护士、临床研究专业人员和参与CCOP、基于少数族裔的CCOP和预防成员的患者提供高质量的癌症预防和控制临床试验，降低癌症发病率和提高生活质量。O具体目标2：在开放标签第二阶段和随机(安慰剂对照)(双盲)第三阶段临床试验中，通过利用传统药物、植物和天然产品、补充和替代疗法以及行为和/或教育干预，预防或减少癌症及其治疗的症状。O具体目标3：增加CCCWFU CCOP研究基地临床试验的招募和留用，特别重视代表性不足的人群，包括少数族裔、妇女、青少年和老年人。癌症控制研究侧重于症状管理(即癌症的症状及其治疗)，分为症状预防和症状治疗两个领域。症状管理研究主题包括心脏毒性、认知功能和情绪、疲劳、潮热、感染、辐射引起的“炎症”(膀胱炎、皮炎、肠炎、食管炎和粘膜炎)、性功能、类固醇毒性、戒烟和与体重相关的问题(厌食和减肥；饮食、运动和体重增加)。癌症预防研究的重点是一级和二级化学预防研究，利用膳食补充剂以及植物和天然产品，包括水果和蔬菜提取物、维生素D及其类似物和鱼油。

DESCRIPTION (provided by applicant): This application represents the second competing renewal of the Comprehensive Cancer Center of Wake Forest University (CCCWFU) Community Clinical Oncology Program (CCOP) Research Base. At present, the Research Base has 11 participating CCOPs (including one Minority-Based CCOP) and 5 Prevention Members, with an additional eight CCOPs (including four MB CCOPs) who are in various stages of joining. The CCCWFU CCOP Research Base has three Specific Aims: o Specific Aim 1: To reduce cancer incidence and improve quality of life by providing high-quality cancer prevention and control clinical trials for the physicians, research nurses, clinical research professionals, and patients from participating CCOPs, Minority-Based CCOPs, and Prevention Members. o Specific Aim 2: To prevent or reduce the symptoms of cancer and its treatments by utilizing conventional pharmacologic agents, botanical and natural products, complementary and alternative therapies, and behavioral and/or educational interventions in open-label Phase II and randomized ( placebo-controlled) ( double-blind) Phase III clinical trials. o Specific Aim 3: To increase recruitment and retention on CCCWFU CCOP Research Base clinical trials, with a particular emphasis on under-represented populations including racial and ethnic minorities, women, adolescents, and the elderly. Cancer Control studies focus on symptom management (i.e., the symptoms of cancer and its treatments), which is divided into the areas of symptom prevention and symptom treatment. Symptom management research themes include cardiotoxicity, cognitive function and mood, fatigue, hot flashes, infections, the radiation-induced "-itises" (cystitis, dermatitis, enteritis, esophagitis, and mucositis), sexual function, steroid toxicity, tobacco cessation, and weight-related issues (anorexia and weight loss; diet, exercise, and weight gain). Cancer prevention research is focused on primary and secondary chemoprevention studies utilizing dietary supplements as well as botanical and natural products, including fruit and vegetable extracts, vitamin D and its analogues, and fish oil.