Comprehensive Cancer Center of Wake Forest COOP Research Base

维克森林大学COOP研究基地综合癌症中心

• 批准号: 8520190
• 负责人: EDWARD G SHAW
• 金额: $ 260.64万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-07 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8520190
• 关键词: Area; Behavior Therapy; Biological Factors; Botanicals; Cancer Control; Cancer Prevention Trial; Collaborations; Communities; Community Clinical Oncology Program; Community Practice; Comprehensive Cancer Center; Controlled Clinical Trials; Controlled Study; Development; Diagnosis; Faculty; Fostering; Funding; Goals; Institution; Intervention Studies; Longevity; Longitudinal Studies; Malignant Neoplasms; Minority Groups; Patients; Prevention; Quality of life; Recording of previous events; Reporting; Research; Science; Symptoms; Time; Toxic effect; Training; base; career; forest; innovation; member; survivorship

DESCRIPTION (provided by applicant): This is the third competing renewal application for the Comprehensive Cancer of Wake Forest Community Clinical Oncology Program Research Base (WF Research Base), which was initially funded in 1999. Specific Aims for the next five years include the following: Specific Aim 1: To conduct cancer control studies that impact community oncology practice by enhancing patients' quality of life through prevention and treatment of symptoms across the survivorship lifespan (i.e., from diagnosis to the end of therapy and from the end of therapy forward) in the following thematic areas: botanical/natural products and other integrative approaches; conventional pharmacologic agents; behavioral interventions; non-intervention studies (e.g., correlative science and observational/longitudinal studies; and cancer prevention trials). Specific Aim 2: To use correlative science in conjunction with WF Research Base cancer control studies to understand the basic mechanisms by which symptoms and toxicities of cancer and its treatments occur. Specific Aim 3: To develop and utilize innovative, culturally-tailored strategies to increase the participation of racial/ethnic minorities traditionaly underrepresented in cancer control studies. Specific Aim 4: To foster active collaboration and offer training in the development, conduct, and reporting of cancer control clinical trials for CCOP/MBCCOP professionals, early career faculty, and trainees. The current application is the strongest competing renewal application for the WF Research Base in our 12 year history. Over time, we have increased the number of studies, accruals, and affiliated communities and institutions. The diversity, depth and breadth of our four open and four soon-to-open studies and 20 developing concepts is evidence of the unique and diverse menu of studies we provide, and the important niche we fill for our participating CCOPs, MBCCOPs and Prevention Members.

说明（由申请人提供）：这是维克森林社区临床肿瘤学综合癌症计划研究基地（WF 研究基地）的第三个竞争续展申请，该基地最初于 1999 年资助。未来五年的具体目标包括以下内容： 具体目标 1：通过在生存期（即从诊断到生命结束）预防和治疗症状来提高患者的生活质量，从而开展影响社区肿瘤学实践的癌症控制研究。 治疗以及从治疗结束开始）在以下主题领域：植物/天然产品和其他综合方法；常规药物；行为干预；非干预研究（例如相关科学和观察/纵向研究；以及癌症预防试验）。具体目标2：利用相关科学与WF研究基地癌症控制研究相结合，了解癌症及其治疗的症状和毒性发生的基本机制。具体目标 3：制定和利用创新的、适合文化的策略，以增加传统上在癌症控制研究中代表性不足的种族/族裔少数群体的参与。具体目标 4：促进积极合作，并为 CCOP/MBCCOP 专业人员、早期职业教师和学员提供癌症控制临床试验的开发、实施和报告方面的培训。目前的申请是WF研究基地12年历史上最具竞争力的续签申请。随着时间的推移，我们增加了研究、应计费用以及附属社区和机构的数量。我们的四项开放研究和四项即将开放的研究以及 20 个正在开发的概念的多样性、深度和广度证明了我们提供的独特且多样化的研究菜单，以及我们为参与的 CCOP、MBCCOP 和预防成员填补的重要空白。

项目成果

A randomized, controlled trial of Panax quinquefolius extract (CVT-E002) to reduce respiratory infection in patients with chronic lymphocytic leukemia.

• DOI: 10.1016/j.suponc.2011.10.005
• 发表时间: 2012-09
• 期刊: The journal of supportive oncology
• 作者: High, Kevin P;Case, Doug;Hurd, David;Powell, Bayard;Lesser, Glenn;Falsey, Ann R;Siegel, Robert;Metzner-Sadurski, Joanna;Krauss, John C;Chinnasami, Bernard;Sanders, George;Rousey, Steven;Shaw, Edward G
• 通讯作者: Shaw, Edward G

Phase II study of Ginkgo biloba in irradiated brain tumor patients: effect on cognitive function, quality of life, and mood.

• DOI: 10.1007/s11060-012-0901-9
• 发表时间: 2012-09
• 期刊: JOURNAL OF NEURO-ONCOLOGY
• 影响因子: 3.9
• 作者: Attia, Albert;Rapp, Stephen R.;Case, L. Doug;D'Agostino, Ralph;Lesser, Glenn;Naughton, Michelle;McMullen, Kevin;Rosdhal, Robin;Shaw, Edward G.
• 通讯作者: Shaw, Edward G.

Symptom clusters in patients with newly-diagnosed brain tumors.

新诊断脑肿瘤患者的症状群。

• 发表时间: 2007
• 期刊: The journal of supportive oncology
• 作者: GleasonJr,JohnF;Case,Douglas;Rapp,StephenR;Ip,Edward;Naughton,Michelle;ButlerJr,JeromeM;McMullen,Kevin;Stieber,Volker;Saconn,Paul;Shaw,EdwardG
• 通讯作者: Shaw,EdwardG

The management of radiation-induced brain injury.

• DOI: 10.1007/0-387-25354-8_2
• 发表时间: 2006
• 期刊: Cancer treatment and research
• 作者: E. Shaw;M. Robbins

Phase II study of carboplatin, irinotecan, and thalidomide in patients with advanced non-small cell lung cancer

• DOI: 10.1097/01243894-200610000-00012
• 发表时间: 2006-10-01
• 期刊: JOURNAL OF THORACIC ONCOLOGY
• 影响因子: 20.4
• 作者: Miller, Antonius A.;Case, Doug;Bearden, James D.
• 通讯作者: Bearden, James D.