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Clinical Research

临床研究

基本信息

批准号：
7529431
负责人：
EDWARD G SHAW
金额：
$ 1.73万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-11 至 2012-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7529431
关键词：
3-Dimensional Academic Medical Centers Anatomy Anthracycline Antibiotics Anthracyclines Area Aricept Basic Science Body Weight decreased Botanicals Brain Brain Injuries Brain Neoplasms Breast Cancer Center Canis familiaris Cardiac Cholecalciferol Cholinergic Agents Clinic Clinical Clinical Oncology Clinical Research Clinical Trials Coenzyme Q10 Cognitive Colorectal Cancer Communities Community Clinical Oncology Program Comprehensive Cancer Center of Wake Forest University Curcumin Cytotoxin DNA Damage Desire for food Diagnosis Diffusion Direct Costs Dysmyelopoietic Syndromes Early Diagnosis Effexor Equipment Esophagitis Excision Fatigue Functional Imaging Funding Future Gemcitabine/Oxaliplatin Ginkgo biloba Hot flushes Human Hypericum perforatum Hypoxia Image Industry Inflammation Intervention Intervention Trial Investigation Investments Laboratory Research Local Therapy Louisiana Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Malignant Glioma Malignant Neoplasms Malignant neoplasm of esophagus Malignant neoplasm of pancreas Malignant neoplasm of prostate Mammography Megestrol Acetate Menopausal hot flushes Metabolism Modality Modeling Molecular Nanotechnology Morbidity - disease rate Mucositis NCI Center for Cancer Research Neoadjuvant Therapy Normal tissue morphology Numbers Operative Surgical Procedures Outpatients Oxandrolone Patients Perfusion Weighted MRI Phase Physiological Positron Positron-Emission Tomography Process Propolis Publishing Radiation therapy Radiation-Sensitizing Agents Radiofrequency Interstitial Ablation Radiosurgery Recombinants Regenerative Medicine Research Research Personnel Scientist Screening procedure Solid Neoplasm Spiral Computed Tomography Staging Therapeutic Tissue Engineering Tissues Toxic effect Translating Universities Veterinary Medicine Veterinary Schools Virginia base cancer therapy cell growth chemotherapeutic agent chemotherapy cholinergic cognitive function comparative donepezil follow-up forest intraperitoneal malignant breast neoplasm member multidisciplinary neuroimaging neurotransmission novel oncology programs receptor soy protein isolate symptom management treatment planning tumor venlafaxine white matter

项目摘要

The Clinical Research Program of the Comprehensive Cancer Center of Wake Forest University (CCCWFU) is organized around three themes: Therapeutic Modulation, Bioanatomic Imaging, and Symptom Management. Therapeutic Modulation focuses on novel local, regional, and systemic treatments for cancer, a number of which have translated from laboratory research discoveries by Cancer Center basic scientists into the clinic. Bioanatomic Imaging is based on the use of anatomic, biologic, physiologic, and functional imaging of cancer and normal tissues for brain, breast, and prostate cancer as well as other solid tumors. Symptom Management studies utilize pharmacologic interventions to reduce the morbidity of cancer and its treatments with an emphasis on novel chemotherapeutic agents, targeted therapies, and botanical and natural compounds. The Clinical Research Program currently has 34 multidisciplinary members, from 17 Departments and Sections. Twenty-three Program members (68%) have NIH/NCI or equivalent funding. There has been a reduction in the number of Program members since 2001 as membership criteria have tightened. However, Program funding (direct costs) has more than tripled, from $1.53M to $5.59M. Program members published 386 articles of which 12.7% were inter-programmatic and 21.5% were intra-programmatic. The Cancer Center as a whole enters >1700 patients per year onto CCCWFU, Cooperative Group, and industry intervention and observational clinical trials; 92% of these are entered by CCCWFU investigators and 8% by CCCWFU affiliates, primarily through the CCCWFU Community Clinical Oncology Program (CCOP) Research Base. The Research Base, one of only six cancer center research bases in the U.S., has grown to include 12 CCOPs and 5 non-CCOPs in 19 states across the U.S., resulting in a network of 92 community cancer centers and 3 academic medical centers (East Carolina University, Louisiana State University, and Wake Forest) performing CCCWFU investigator-initiated clinical trials. Accrual onto all CCCWFU Phase I, II, and III intervention trials has more than doubled since 2001 to about 600 per year at present. Institutional investment for clinical oncology and clinical imaging research to support the Clinical Research Program has been outstanding, with >$20 million spent on imaging equipment for the Center for Biomolecular Imaging, and >$75 million on a new multidisciplinary outpatient cancer center, which opened in May 2004. Areas of future multidisciplinary and/or interprogrammatic investigations within current clinical research themes include: 1) Regenerative medicine and tissue engineering in oncology; 2) Nanotechnology and molecular materials in oncology; and 3) Canine models of malignant gliomas (with the Virginia Tech School of Veterinary Medicine Center of Comparative Oncology).

维克森林大学综合癌症中心临床研究项目 (CCCWFU) 围绕三个主题组织：治疗调节、生物解剖成像和症状管理。治疗调节专注于癌症的新型局部、区域和全身治疗，其中许多是从癌症中心基础科学家的实验室研究发现转化而来的进入诊所。生物解剖成像基于解剖学、生物学、生理学和功能学的使用脑癌、乳腺癌、前列腺癌以及其他实体瘤的癌症和正常组织成像。症状管理研究利用药物干预来降低癌症及其发病率治疗重点是新型化疗药物、靶向治疗以及植物和药物天然化合物。临床研究项目目前有 34 名多学科成员，来自 17 个部门和部分。 23 名计划成员 (68%) 拥有 NIH/NCI 或同等资金。已经有一个自 2001 年以来，由于会员标准收紧，计划会员数量有所减少。然而，计划资金（直接成本）增加了两倍多，从 153 万美元增至 559 万美元。计划成员发表 386 篇文章，其中 12.7% 为程序间文章，21.5% 为程序内文章。整个癌症中心每年将超过 1700 名患者纳入 CCCWFU、合作组和行业干预和观察性临床试验；其中 92% 由 CCCWFU 调查员输入 8% 由 CCCWFU 附属机构提供，主要通过 CCCWFU 社区临床肿瘤学计划 (CCOP) 研究基地。该研究基地是美国仅有的六个癌症中心研究基地之一，发展到包括美国 19 个州的 12 个 CCOP 和 5 个非 CCOP，网络规模达到 92 个社区癌症中心和 3 个学术医疗中心（东卡罗来纳大学、路易斯安那州大学和维克森林大学）进行 CCCWFU 研究者发起的临床试验。全部应计自 2001 年以来，CCCWFU I、II 和 III 期干预试验增加了一倍多，达到每年约 600 项展示。对临床肿瘤学和临床影像研究的机构投资，以支持临床研究计划非常出色，该中心在成像设备上花费了超过 2000 万美元生物分子成像，以及超过 7500 万美元用于新的多学科门诊癌症中心，该中心于 2017 年开业 2004 年 5 月。当前临床研究中未来多学科和/或跨项目研究的领域主题包括：1）肿瘤学中的再生医学和组织工程； 2）纳米技术和肿瘤学中的分子材料； 3）恶性神经胶质瘤的犬模型（与弗吉尼亚理工学院合作）比较肿瘤学兽医中心）。