Clinical Research

维克森林大学综合癌症中心的临床研究计划 (CCCWFU)围绕三个主题组织：治疗调节、生物解剖成像和症状 管理层。治疗调节侧重于癌症的新的局部、区域和系统治疗， 其中一些是从癌症中心基础科学家的实验室研究发现转化而来的 送进诊所。生物解剖学成像基于解剖学、生物学、生理学和功能性的使用 对脑、乳腺癌、前列腺癌和其他实体肿瘤的癌症和正常组织进行成像。 症状管理研究利用药物干预降低癌症及其相关疾病的发病率 治疗，重点是新的化疗药物，靶向治疗，以及植物和 天然化合物。 临床研究计划目前有34名多学科成员，来自17个科室和 横断面。23名计划成员(68%)拥有NIH/NCI或同等资助。已经有了一个 自2001年以来，由于成员标准收紧，计划成员的数量有所减少。然而， 项目资金(直接成本)增加了两倍多，从153万美元增至559万美元。计划成员已发布 386篇文章，其中12.7%是方案间的，21.5%是方案内的。 癌症中心作为一个整体，每年有1700名患者加入CCCWFU、合作组织和 行业干预和观察性临床试验；其中92%由CCCWFU调查人员参与 8%由CCCWFU附属机构提供，主要通过CCCWFU社区临床肿瘤学计划 (CCOP)研究基地。研究基地是美国仅有的六个癌症中心研究基地之一， 增长到包括美国19个州的12个CCOP和5个非CCOP，从而形成了92个网络 社区癌症中心和3个学术医疗中心(路易斯安那州东卡罗来纳大学 大学和维克森林公司)进行CCCWFU研究员发起的临床试验。应计入所有人 CCCWFU第一、第二和第三阶段干预试验自2001年来增加了一倍多，达到每年约600项 现在时。 机构对临床肿瘤学和临床影像研究的投资，以支持临床 研究计划一直很出色，为该中心购买成像设备花费了2000万美元 生物分子成像，以及投资7500万美元建立一个新的多学科门诊癌症中心，该中心于 2004年5月。 当前临床研究中未来多学科和/或跨计划研究的领域 主题包括：1)肿瘤学中的再生医学和组织工程；2)纳米技术和 肿瘤学中的分子材料；3)犬恶性胶质瘤模型(与弗吉尼亚理工学院合作 比较肿瘤学兽医中心)。

The Clinical Research Program of the Comprehensive Cancer Center of Wake Forest University (CCCWFU) is organized around three themes: Therapeutic Modulation, Bioanatomic Imaging, and Symptom Management. Therapeutic Modulation focuses on novel local, regional, and systemic treatments for cancer, a number of which have translated from laboratory research discoveries by Cancer Center basic scientists into the clinic. Bioanatomic Imaging is based on the use of anatomic, biologic, physiologic, and functional imaging of cancer and normal tissues for brain, breast, and prostate cancer as well as other solid tumors. Symptom Management studies utilize pharmacologic interventions to reduce the morbidity of cancer and its treatments with an emphasis on novel chemotherapeutic agents, targeted therapies, and botanical and natural compounds. The Clinical Research Program currently has 34 multidisciplinary members, from 17 Departments and Sections. Twenty-three Program members (68%) have NIH/NCI or equivalent funding. There has been a reduction in the number of Program members since 2001 as membership criteria have tightened. However, Program funding (direct costs) has more than tripled, from $1.53M to $5.59M. Program members published 386 articles of which 12.7% were inter-programmatic and 21.5% were intra-programmatic. The Cancer Center as a whole enters >1700 patients per year onto CCCWFU, Cooperative Group, and industry intervention and observational clinical trials; 92% of these are entered by CCCWFU investigators and 8% by CCCWFU affiliates, primarily through the CCCWFU Community Clinical Oncology Program (CCOP) Research Base. The Research Base, one of only six cancer center research bases in the U.S., has grown to include 12 CCOPs and 5 non-CCOPs in 19 states across the U.S., resulting in a network of 92 community cancer centers and 3 academic medical centers (East Carolina University, Louisiana State University, and Wake Forest) performing CCCWFU investigator-initiated clinical trials. Accrual onto all CCCWFU Phase I, II, and III intervention trials has more than doubled since 2001 to about 600 per year at present. Institutional investment for clinical oncology and clinical imaging research to support the Clinical Research Program has been outstanding, with >$20 million spent on imaging equipment for the Center for Biomolecular Imaging, and >$75 million on a new multidisciplinary outpatient cancer center, which opened in May 2004. Areas of future multidisciplinary and/or interprogrammatic investigations within current clinical research themes include: 1) Regenerative medicine and tissue engineering in oncology; 2) Nanotechnology and molecular materials in oncology; and 3) Canine models of malignant gliomas (with the Virginia Tech School of Veterinary Medicine Center of Comparative Oncology).