Clinical Research

临床研究

基本信息

批准号：
7529431
负责人：
EDWARD G SHAW
金额：
$ 1.73万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-11 至 2012-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7529431
关键词：
3-Dimensional Academic Medical Centers Anatomy Anthracycline Antibiotics Anthracyclines Area Aricept Basic Science Body Weight decreased Botanicals Brain Brain Injuries Brain Neoplasms Breast Cancer Center Canis familiaris Cardiac Cholecalciferol Cholinergic Agents Clinic Clinical Clinical Oncology Clinical Research Clinical Trials Coenzyme Q10 Cognitive Colorectal Cancer Communities Community Clinical Oncology Program Comprehensive Cancer Center of Wake Forest University Curcumin Cytotoxin DNA Damage Desire for food Diagnosis Diffusion Direct Costs Dysmyelopoietic Syndromes Early Diagnosis Effexor Equipment Esophagitis Excision Fatigue Functional Imaging Funding Future Gemcitabine/Oxaliplatin Ginkgo biloba Hot flushes Human Hypericum perforatum Hypoxia Image Industry Inflammation Intervention Intervention Trial Investigation Investments Laboratory Research Local Therapy Louisiana Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Malignant Glioma Malignant Neoplasms Malignant neoplasm of esophagus Malignant neoplasm of pancreas Malignant neoplasm of prostate Mammography Megestrol Acetate Menopausal hot flushes Metabolism Modality Modeling Molecular Nanotechnology Morbidity - disease rate Mucositis NCI Center for Cancer Research Neoadjuvant Therapy Normal tissue morphology Numbers Operative Surgical Procedures Outpatients Oxandrolone Patients Perfusion Weighted MRI Phase Physiological Positron Positron-Emission Tomography Process Propolis Publishing Radiation therapy Radiation-Sensitizing Agents Radiofrequency Interstitial Ablation Radiosurgery Recombinants Regenerative Medicine Research Research Personnel Scientist Screening procedure Solid Neoplasm Spiral Computed Tomography Staging Therapeutic Tissue Engineering Tissues Toxic effect Translating Universities Veterinary Medicine Veterinary Schools Virginia base cancer therapy cell growth chemotherapeutic agent chemotherapy cholinergic cognitive function comparative donepezil follow-up forest intraperitoneal malignant breast neoplasm member multidisciplinary neuroimaging neurotransmission novel oncology programs receptor soy protein isolate symptom management treatment planning tumor venlafaxine white matter

项目摘要

The Clinical Research Program of the Comprehensive Cancer Center of Wake Forest University (CCCWFU) is organized around three themes: Therapeutic Modulation, Bioanatomic Imaging, and Symptom Management. Therapeutic Modulation focuses on novel local, regional, and systemic treatments for cancer, a number of which have translated from laboratory research discoveries by Cancer Center basic scientists into the clinic. Bioanatomic Imaging is based on the use of anatomic, biologic, physiologic, and functional imaging of cancer and normal tissues for brain, breast, and prostate cancer as well as other solid tumors. Symptom Management studies utilize pharmacologic interventions to reduce the morbidity of cancer and its treatments with an emphasis on novel chemotherapeutic agents, targeted therapies, and botanical and natural compounds. The Clinical Research Program currently has 34 multidisciplinary members, from 17 Departments and Sections. Twenty-three Program members (68%) have NIH/NCI or equivalent funding. There has been a reduction in the number of Program members since 2001 as membership criteria have tightened. However, Program funding (direct costs) has more than tripled, from $1.53M to $5.59M. Program members published 386 articles of which 12.7% were inter-programmatic and 21.5% were intra-programmatic. The Cancer Center as a whole enters >1700 patients per year onto CCCWFU, Cooperative Group, and industry intervention and observational clinical trials; 92% of these are entered by CCCWFU investigators and 8% by CCCWFU affiliates, primarily through the CCCWFU Community Clinical Oncology Program (CCOP) Research Base. The Research Base, one of only six cancer center research bases in the U.S., has grown to include 12 CCOPs and 5 non-CCOPs in 19 states across the U.S., resulting in a network of 92 community cancer centers and 3 academic medical centers (East Carolina University, Louisiana State University, and Wake Forest) performing CCCWFU investigator-initiated clinical trials. Accrual onto all CCCWFU Phase I, II, and III intervention trials has more than doubled since 2001 to about 600 per year at present. Institutional investment for clinical oncology and clinical imaging research to support the Clinical Research Program has been outstanding, with >$20 million spent on imaging equipment for the Center for Biomolecular Imaging, and >$75 million on a new multidisciplinary outpatient cancer center, which opened in May 2004. Areas of future multidisciplinary and/or interprogrammatic investigations within current clinical research themes include: 1) Regenerative medicine and tissue engineering in oncology; 2) Nanotechnology and molecular materials in oncology; and 3) Canine models of malignant gliomas (with the Virginia Tech School of Veterinary Medicine Center of Comparative Oncology).

维克森林大学综合癌症中心的临床研究计划（CCCWFU）围绕三个主题进行组织：治疗调制，生物印度成像和症状管理。治疗调节着重于癌症的新型局部，区域和系统治疗，其中许多是从癌症中心基础科学家的实验室研究发现中翻译的进入诊所。生物印度成像基于解剖学，生物学，生理和功能的使用大脑，乳腺癌和前列腺癌以及其他实体瘤的癌症和正常组织的成像。症状管理研究利用药理干预措施来减少癌症的发病率重点是新型化学治疗剂，靶向疗法以及植物学和天然化合物。该临床研究计划目前有17个部门的34名跨学科成员，部分。 23个计划成员（68％）拥有NIH/NCI或同等资金。有一个自2001年以来，随着成员标准的增加，计划成员的数量减少了。然而，计划资金（直接成本）的两倍以上，从153万美元到559万美元。计划成员发布 386篇文章，其中12.7％为程序间，21.5％是概括性内的。整个癌症中心每年进入> 1700名患者，加入CCCWFU，合作组和行业干预和观察性临床试验；其中92％由CCCWFU调查人员输入 CCCWFU分支机构为8％，主要是通过CCCWFU社区临床肿瘤计划（CCOP）研究基础。该研究基础是美国仅有的六个癌症中心研究基地之一，成长为在美国的19个州中包括12个CCOP和5个非CCOP，导致92个网络社区癌症中心和3个学术医疗中心（路易斯安那州东卡罗来纳大学大学和Wake Forest）进行CCCWFU研究者发起的临床试验。应计入所有人自2001年以来，CCCWFU I期，II和III阶段的干预试验已翻了一番，达到每年约600 展示。临床肿瘤学和临床成像研究的机构投资以支持临床研究计划非常出色，在该中心的成像设备上花费了超过2000万美元生物分子成像，在一个新的多学科门诊癌症中心上> 7500万美元，该中心开业 2004年5月。当前临床研究中未来的多学科和/或跨学科调查的领域主题包括：1）肿瘤学中的再生医学和组织工程； 2）纳米技术和肿瘤学中的分子材料；和3）恶性神经胶质瘤的犬类模型（弗吉尼亚理工学院比较肿瘤学兽医医学中心）。