CCCWFU RESEARCH BASE GRANT

本研究基地申请描述了癌症预防和控制研究和癌症治疗研究的管理结构和阵列，这些研究将使维克森林大学(CCCWFU)综合癌症中心(CCCWFU)成为四个社区临床肿瘤学项目(CCOP)的研究基地，包括东南癌症控制联盟、北卡罗来纳州CCOP、格林维尔(SC)CCOP和弗吉尼亚少数民族医学院CCOP。此外，东卡罗来纳大学(ECU)将成为研究基地的非CCOP参与者。该研究基地包括CCCWFU和ECU患者，将为来自七个州(北卡罗来纳州、南卡罗来纳州、弗吉尼亚州、西弗吉尼亚州、肯塔基州、田纳西州和佐治亚州)的患者提供服务，其中包括20个社区癌症中心和2个大学癌症中心。在这个庞大的地理区域，人口基数超过1000万人，其中包括高达60%的少数族裔，主要是非裔美国人。癌症预防和控制研究将集中在症状管理和一级和二级化学预防研究上。癌症治疗研究将集中于在各种转移性实体肿瘤中应用化疗药物的新组合或途径，以及在生物化学复发的前列腺癌中使用维生素D作为抗癌和分化药物(直接转化为社区环境的“BASE”研究的一个例子)。赠款的首席研究员将是CCCWFU临床研究副主任Edward G.Shaw，医学博士。联合调查员和指导委员会成员使研究基地的科学领导具有广泛的多学科代表性，包括公共卫生科学、血液学/肿瘤学、放射肿瘤学、外科肿瘤学和癌症生物学。总而言之，CCCWFU研究基础补助金将通过降低癌症发病率、提高治疗效率、最大限度地减少治疗发病率和改善护理质量，服务于美国东南部的CCOP，并进一步促进癌症中心对其当地和地区社区(包括大量少数群体和未得到充分服务的人群)的拓展和影响。

This Research Base application describes the administrative structure and array of cancer prevention and control studies and cancer treatment studies that will allow the Comprehensive Cancer Center of Wake Forest University (CCCWFU) to be a Research Base for four Community Clinical Oncology Programs (CCOP's) including the Southeast Cancer Control Consortium, Upstate Carolina CCOP, Greenville (SC) CCOP, and Medical College of Virginia Minority CCOP. In addition, East Carolina University (ECU) will be a non- CCOP participant in the Research Base. Including CCCWFU and ECU patients, the Research Base will serve patients from seven states (NC, SC, VA, WV, KY, TN, and GA), which encompasses 20 community and 2 university Cancer Centers. The population base in this large geographic region is in excess of 10 million people, including communities with up to 60 percent minorities, mainly African-Americans. The cancer prevention and control research will focus on symptom management and primary and secondary chemoprevention studies. The cancer treatment research will focus on novel combinations or routes of administration of chemotherapeutic agents in a variety of metastatic solid tumors and vitamin D as an anti-cancer and differentiating agent in biochemically recurrent prostate cancer (an example of "bench" research translating directly into the community setting). The Principal Investigator of the grant will be Edward G. Shaw, M.D., Associate Director of Clinical Research for the CCCWFU. The Co-Investigators and members of the Steering Committee give the scientific leadership of the Research Base broad multidisciplinary representation including those from Public Health Sciences, Hematology/Oncology, Radiation Oncology, Surgical Oncology, and Cancer Biology. In summary, the CCCWFU Research Base Grant will serve the CCOP's of the Southeast United States and further the Cancer Center's outreach and impact on its local and regional communities, which include significant minority and underserved populations, by reducing cancer incidence, improving treatment efficacy, minimizing treatment morbidity, and improving the quality of care.