CCCWFU RESEARCH BASE GRANT

该研究基地申请描述了癌症预防和控制研究以及癌症治疗研究的行政结构和阵列，这将使维克森林大学综合癌症中心（CCCWFU）成为四个社区临床肿瘤项目（CCOP）的研究基地，包括东南癌症控制联盟、北卡罗莱纳州CCOP、格林维尔（SC） CCOP和弗吉尼亚少数民族医学院CCOP。此外，东卡罗莱纳大学（ECU）将是研究基地的非CCOP参与者。包括CCCWFU和ECU患者在内，研究基地将为来自七个州（北卡罗来纳州，南卡罗来纳州，弗吉尼亚州，弗吉尼亚州，肯塔基州，田纳西州和佐治亚州）的患者提供服务，其中包括20个社区和2所大学癌症中心。这一广阔地理区域的人口基数超过1000万，其中包括少数民族占60%的社区，主要是非洲裔美国人。癌症的预防和控制研究将侧重于症状管理和一级和二级化学预防研究。癌症治疗研究将侧重于各种转移性实体肿瘤的化疗药物的新组合或给药途径，以及维生素D作为生化复发性前列腺癌的抗癌和分化剂（“实验”研究直接转化为社区环境的一个例子）。该基金的首席研究员将是Edward G. Shaw，医学博士，CCCWFU临床研究副主任。联合研究者和指导委员会成员为研究基地提供了广泛的多学科代表的科学领导，包括公共卫生科学、血液学/肿瘤学、放射肿瘤学、外科肿瘤学和癌症生物学。总而言之，CCCWFU研究基地赠款将服务于美国东南部的cccop，并通过降低癌症发病率，提高治疗效果，最大限度地减少治疗发病率和提高护理质量，进一步扩大癌症中心在当地和区域社区的影响，包括重要的少数民族和服务不足的人群。

This Research Base application describes the administrative structure and array of cancer prevention and control studies and cancer treatment studies that will allow the Comprehensive Cancer Center of Wake Forest University (CCCWFU) to be a Research Base for four Community Clinical Oncology Programs (CCOP's) including the Southeast Cancer Control Consortium, Upstate Carolina CCOP, Greenville (SC) CCOP, and Medical College of Virginia Minority CCOP. In addition, East Carolina University (ECU) will be a non- CCOP participant in the Research Base. Including CCCWFU and ECU patients, the Research Base will serve patients from seven states (NC, SC, VA, WV, KY, TN, and GA), which encompasses 20 community and 2 university Cancer Centers. The population base in this large geographic region is in excess of 10 million people, including communities with up to 60 percent minorities, mainly African-Americans. The cancer prevention and control research will focus on symptom management and primary and secondary chemoprevention studies. The cancer treatment research will focus on novel combinations or routes of administration of chemotherapeutic agents in a variety of metastatic solid tumors and vitamin D as an anti-cancer and differentiating agent in biochemically recurrent prostate cancer (an example of "bench" research translating directly into the community setting). The Principal Investigator of the grant will be Edward G. Shaw, M.D., Associate Director of Clinical Research for the CCCWFU. The Co-Investigators and members of the Steering Committee give the scientific leadership of the Research Base broad multidisciplinary representation including those from Public Health Sciences, Hematology/Oncology, Radiation Oncology, Surgical Oncology, and Cancer Biology. In summary, the CCCWFU Research Base Grant will serve the CCOP's of the Southeast United States and further the Cancer Center's outreach and impact on its local and regional communities, which include significant minority and underserved populations, by reducing cancer incidence, improving treatment efficacy, minimizing treatment morbidity, and improving the quality of care.