CCCWFU RESEARCH BASE GRANT

CCCWFU研究基地资助

• 批准号: 6377259
• 负责人: EDWARD G SHAW
• 金额: $ 57.24万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-07 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6377259
• 关键词: antineoplastics; behavioral /social science research tag; cancer prevention; cancer rehabilitation /care; chemoprevention; clinical research; clinical trials; community health services; cooperative study; drug administration routes; health services research tag; human subject; human therapy evaluation; male; medical outreach /case finding; medical rehabilitation related tag; metastasis; neoplasm /cancer chemotherapy; neoplasm /cancer education; neoplasm /cancer therapy; primary care physician; prostate neoplasms; vitamin D; vitamin therapy

This Research Base application describes the administrative structure and array of cancer prevention and control studies and cancer treatment studies that will allow the Comprehensive Cancer Center of Wake Forest University (CCCWFU) to be a Research Base for four Community Clinical Oncology Programs (CCOP's) including the Southeast Cancer Control Consortium, Upstate Carolina CCOP, Greenville (SC) CCOP, and Medical College of Virginia Minority CCOP. In addition, East Carolina University (ECU) will be a non- CCOP participant in the Research Base. Including CCCWFU and ECU patients, the Research Base will serve patients from seven states (NC, SC, VA, WV, KY, TN, and GA), which encompasses 20 community and 2 university Cancer Centers. The population base in this large geographic region is in excess of 10 million people, including communities with up to 60 percent minorities, mainly African-Americans. The cancer prevention and control research will focus on symptom management and primary and secondary chemoprevention studies. The cancer treatment research will focus on novel combinations or routes of administration of chemotherapeutic agents in a variety of metastatic solid tumors and vitamin D as an anti-cancer and differentiating agent in biochemically recurrent prostate cancer (an example of "bench" research translating directly into the community setting). The Principal Investigator of the grant will be Edward G. Shaw, M.D., Associate Director of Clinical Research for the CCCWFU. The Co-Investigators and members of the Steering Committee give the scientific leadership of the Research Base broad multidisciplinary representation including those from Public Health Sciences, Hematology/Oncology, Radiation Oncology, Surgical Oncology, and Cancer Biology. In summary, the CCCWFU Research Base Grant will serve the CCOP's of the Southeast United States and further the Cancer Center's outreach and impact on its local and regional communities, which include significant minority and underserved populations, by reducing cancer incidence, improving treatment efficacy, minimizing treatment morbidity, and improving the quality of care.

该研究基础应用描述了癌症预防和控制研究和癌症治疗研究的行政结构和阵列，这些研究将使Wake Forest大学（CCCWFU）综合癌症中心成为四个社区临床肿瘤学计划（CCOP）的研究基础，包括东南癌症联盟，绿色CCCOP，Greenville（SC）CCOP和Medical Consity CCCCCOP和Medical Ccop。 此外，东卡罗来纳大学（ECU）将是研究基础的非CCOP参与者。 包括CCCWFU和ECU患者在内，研究基础将为来自七个州（NC，SC，VA，WV，KY，TN和GA）的患者提供服务，其中包括20个社区和2个大学癌症中心。 这个庞大的地理区域的人口基础超过1000万人，其中包括多达60％的少数民族，主要是非裔美国人的社区。 癌症预防和控制研究将集中于症状管理以及初级和继发性化学预防研究。 癌症治疗研究将集中于多种转移性实体瘤中化学治疗剂的新型组合或给药途径，以及维生素D作为抗癌和分化剂的生物化学复发前列腺癌（一个直接转化为社区环境的“基础”研究的例子））。 赠款的主要研究人员将是CCCWFU临床研究副主任Edward G. Shaw。 指导委员会的共同投资者和成员赋予了研究基础的科学领导，包括公共卫生科学，血液学/肿瘤学，辐射肿瘤学，外科肿瘤学和癌症生物学的多学科代表。 总而言之，CCCWFU研究基础赠款将为美国东南部的CCOP提供服务，并进一步促进癌症中心对其本地和地区社区的外展和影响，包括大量少数群体和服务不足的人群，通过降低癌症的发病率，提高治疗效率，最大程度地减少治疗疗法，并提高护理质量。