CONDITIONED RESPONSE TIMING AND INTEGRATION

条件响应时机和整合

• 批准号: 6165212
• 负责人: JOHN W MOORE
• 金额: $ 10.82万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-10 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6165212
• 关键词: behavioral /social science research tag; cerebellar cortex; conditioning; eye movements; laboratory rabbit; model design /development; neural information processing; neurons; psychological models; single cell analysis; stimulus /response

DESCRIPTION (Adapted from applicant's abstract): A central question in the neurobiology of learning and memory is the extent to which single neurons integrate real-time information from multiple sources. Predictions of Sutton and Barto's 1990 Time Derivative (TD) model of Pavlovian learning will be tested in behavioral and single-unit recording studies of the cerebellum, using the conditioned rabbit eyeblink response as a model system. Because its parametric features and neural substrates have been well characterized, classical eyeblink conditioning in humans and other species has been applied to several health related problem-areas, including aging, brain function, development, drug abuse, and toxicology. A growing body of evidence from a variety of methodologies suggests that the cerebellum is essential for learning and performance of conditioned eyeblink responses. The aim is to determine whether the firing patterns of single neurons in the cerebellum are capable of representing the timing and amplitude of classically conditioned eyeblink responses among rabbits trained in paradigms requiring real-time integration of information about the timing and likelihood of the unconditioned stimuli (US). Conditioned responses typically anticipate the timing of the US, but the peak amplitude of the response corresponds to the temporal locus of the US. Training with two conditioned stimulus (CS)-US intervals, which vary randomly from one training trial to the next, a paradigm called temporal uncertainty, produces bimodal response topographies. Because they reflect two expectations of US timing, such bimodal responses express temporal integration. Other paradigms that require this sort of processing include blocking, second-order conditioning, conditioned inhibition, and others. The research plan has three components. (1) behavioral tests of the TD model regarding conditioned response topography; (2) micro-electrode recording from single neurons of the cerebellum after animals have achieved stable (asymptotic) modes of responding; (3) development and evaluation of a cerebellar implementation of the TD model.

描述（改编自申请人的摘要）： 学习和记忆的神经生物学是单个神经元的程度 整合来自多个来源的实时信息。 的预测 Sutton 和 Barto 1990 年的巴甫洛夫学习时间导数 (TD) 模型 将在行为和单单元记录研究中进行测试 小脑，使用条件性兔子眨眼反应作为模型 系统。 因为它的参数特征和神经基质已经被 人类和其他动物的典型眨眼条件反射 该物种已应用于多个与健康相关的问题领域，包括 衰老、脑功能、发育、药物滥用和毒理学。 一个不断成长的 来自各种方法论的大量证据表明 小脑对于条件性眨眼的学习和表现至关重要 回应。 目的是确定单发的射击模式是否 小脑中的神经元能够代表时间和 兔子经典条件性眨眼反应的幅度 接受了需要实时集成信息的范式培训 无条件刺激的时间和可能性（美国）。 有条件的 响应通常会预测美国的时间，但峰值幅度 响应的对应于美国的时间轨迹。 训练与 两个条件刺激 (CS)-US 间隔，从一个随机变化 下一个训练试验，一种称为时间不确定性的范式，产生 双峰响应拓扑。 因为它们反映了美国的两种期望 时间上，这种双峰反应表达了时间整合。 其他 需要这种处理的范例包括阻塞， 二阶条件作用、条件抑制等。 研究 计划由三个部分组成。 (1) TD模型的行为测试 条件反应地形； (2) 单片微电极记录 动物达到稳定（渐近）后的小脑神经元 回应方式； (3) 小脑的发育和评估 TD模型的实施。