CORE--ANIMAL HEALTH AND SAMPLE PROCUREMENT

总体目标是确保 PPG 动物的最佳健康和护理，以实现所有项目的具体目标。 它是该 PPG 的核心部分，负责动物资源、样本采集、许多生物标志物评估的性能以及数据的整理、验证和传输的各个方面。 为了实现这些目标：该核心有六个具体目标： 1. 根据需要提供日常护理，包括兽医和医疗治疗，以确保所有 PPG 动物的健康和福祉。 对此。 该核心明确定义了每只动物将经历的研究程序。 此外，还将创建个人医疗记录以优化兽医护理。 2. 维持治疗组的营养定义。 我们的饮食和食物分配调整的适应症都有明确的指示。 3. 收集样品并将其分发到适当的项目或实验室。 4. 进行核心生物标志物测定。 5. 对该核心获得的数据进行整理和传输，并咨询数据库管理。 描述了数据输入和跟踪程序。 6. 进行完整的尸检大体和微观研究，以记录疾病和死因，包括采购和储存组织以供将来研究。 疾病状况和死亡原因的记录对于 PPG 的长期目标至关重要。这需要彻底的宏观和微观评估，现在阐述了其程序。 虽然后续组织评估的作用尚不清楚，但由于死亡相关事件（例如低血压）可能会改变结果，我们将获取样本用于未来评估。

The over-arching goal is to assure optimal health and care of PPG animals to allow the Specific Aims of all projects to be achieved. It is a central aspect of this PPG a it is responsible for all aspects of the animal resource, specimen acquisition, performance of many biomarker assessments as well as collation, validation, and transmission of data. To meet these goals: This Core has six Specific Aims: 1. Provide daily care including veterinary and medical treatment as need to assure health and well being of all PPG animals. In this regard. this core clearly defines study procedures that each animal will undergo. Further, individual medical records will be created to optimize veterinary care. 2. Maintain nutritionally defined treatment groups. Our diets and indications for food allotment adjustments are clearly indicated. 3. Collect and dispense samples to the appropriate project or laboratory. 4. Conduct core biomarker assays. 5. Collation and transmission of data obtained by this core and its Consultations to the database manage. Data entry and tracking procedures are described. 6. Performance of complete gross and microscopic study postmortem to document disease and cause of death including procurement and storage of tissues for future study. Documentation of disease status and cause of death will be crucial to PPG long term goals. This requires thorough gross and microscopic evaluation, the procedures for which are now stated. While the role of subsequent tissue evaluation is less clear, as death associated events (e.g., hypotension) could alter results, we will obtain samples for future evaluation.