BISPHOSPHONATE ZOLEDRONATE PREVENTS OSTEOPENIA AFTER OVARIECTOMY: OSTEOPOROSIS

目的：论证循序渐进的发展 去卵巢恒河猴骨量减少可通过以下方法预防 用强效双膦酸唑来膦酸盐治疗。结果 卵巢切除导致腰椎迅速失去~8%的骨和 全身上下。这是通过以下方式以剂量依赖的方式防止的 唑来磷酸钠。这项研究是对 雌激素耗竭、骨丢失及双膦酸类药物的作用 在恒河猴身上的这种损失的复合体。隆起的骨骼 周转明显，并呈剂量依赖性抑制。 唑来磷酸钠。这些结果表明，这种化合物很可能 对预防和治疗骨质疏松症有效 绝经后的女性。未来发展方向量化 组织形态计量学评价及生物力学强度测试 这项研究的样本正在等待中。关键词骨质疏松症 双膦酸脂、雌激素消耗、骨密度、骨强度

OBJECTIVE: To demonstrate that the development of progressive osteopenia in ovariectomized rhesus monkeys can be prevented by treatment with the potent bisphosphonate zoledronate. RESULTS Ovariectomy produced rapid bone loss of ~8% at the lumbar spine and total body. This was prevented in a dose-dependent fashion by zoledronate. This study was the most comprehensive assessment of estrogen depletion bone loss and the effect of a bisphosphonate compound on this loss in the rhesus monkey. Elevated skeletal turnover was clearly demonstrated and was suppressed dose dependently by zoledronate. These results suggest that this compound will likely prove efficacious in the prevention and treatment of osteoporosis in postmenopausal women. FUTURE DIRECTIONS Quantitative histomorphometric assessment and biomechanical strength testing of samples from this study are pending. KEY WORDS Osteoporosis, bisphosphonate, estrogen-depletion, bone density, bone strength