USE OF CENTRAL REGION OF INTEREST ANALYSIS IN PA SPINE DXA

中心区兴趣分析在 PA 脊柱 DXA 中的应用

• 批准号: 6116411
• 负责人: NEIL C BINKLEY
• 金额: $ 5.85万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116411
• 关键词: Mammalia; aging; radiology; skeletal system

OBJECTIVE To assess the effect of advancing age upon the development of lumbar spine degenerative arthritis in rhesus monkeys and the use of a custom central region of interest to minimize the impact of this process upon the bone mineral density as measured by DXA. RESULTS The prevalence of degenerative spinal arthritis dramatically increases at age 19 in female rhesus monkeys. Utilization of our custom central region of interest analysis program allows demonstration of ovariectomy induced bone loss with comparable sensitivity as standard analysis and does demonstrate an age-related decline in lumbar spine bone mineral density. FUTURE DIRECTIONS Application of similar custom region of interest analysis programs to human clinical DXA scans to assess if this improves the diagnostic sensitivity by excluding the spurious elevation of BMD due to degenerative spinal arthritis. KEY WORDS Osteoporosis, age-related, bone density FUNDING Geriatrics section discretionary funds PUBLICATIONS Krueger, D., Todd, H., Haffa, A., Bruner, J., Yandow, D., & Binkley, N. Use of central region of interest analysis in AP spine DXA. (Presented at ISCD annual meeting, 1/98). [A] Krueger, D., Vallarta-Ast, N., & Binkley N. Lumbar Spine Densitometry Vertebral Region of Interest Analysis in Older Adults Bone, 23(5 suppl) S485. [A]

目的探讨增龄对老年人心理健康的影响。 恒河猴腰椎退行性关节炎的实验研究 并使用感兴趣的自定义中心区域来最小化 这一过程对骨密度的影响 DXA。结果退行性脊柱炎的患病率 雌性恒河猴在19岁时体重急剧增加。 利用我们的定制中心感兴趣区域分析程序 允许演示卵巢切除所致的骨丢失 敏感度作为标准分析，确实证明了与年龄相关的 腰椎骨密度下降。未来方向 相似自定义感兴趣区域分析程序在 人体临床DXA扫描以评估这是否改善了诊断 通过排除因以下原因引起的骨密度假性升高而获得的灵敏度 退行性脊椎关节炎。关键词骨质疏松症，年龄相关， 骨密度基金老年病科可自由支配基金 首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细文摘内容 &Binkley，N.在AP脊柱中使用中央感兴趣区域分析 DXA。(在国际科学理事会年会上提交，1998年1月)。A.Krueger，D. 腰椎密度测量椎体 老年人骨骼的兴趣区分析，23(5补充)S485。 [A]