USE OF CENTRAL REGION OF INTEREST ANALYSIS IN PA SPINE DXA: OSTEOPOROSIS

目的：评估年龄增长对 恒河猴腰椎退行性关节炎的发生 以及使用感兴趣的定制中心区域来最小化 这一过程对骨矿物质密度的影响， DXA 结果退行性脊柱关节炎的患病率 雌性恒河猴在19岁时会急剧增加。 利用我们的自定义中心感兴趣区域分析程序 允许证明卵巢切除术引起的骨丢失， 敏感性作为标准分析，并证明了年龄相关 腰椎骨密度下降。 未来方向 应用类似的定制感兴趣区域分析程序， 人类临床DXA扫描，以评估这是否改善了诊断 通过排除由于以下原因导致的BMD假性升高， 退行性脊柱关节炎 关键词骨质疏松症，年龄相关， 骨密度

OBJECTIVE: To assess the effect of advancing age upon the development of lumbar spine degenerative arthritis in rhesus monkeys and the use of a custom central region of interest to minimize the impact of this process upon the bone mineral density as measured by DXA. RESULTS The prevalence of degenerative spinal arthritis dramatically increases at age 19 in female rhesus monkeys. Utiliziation of our custom central region of interest analysis program allows demonstration of ovariectomy induced bone loss with comparable sensitivity as standard analysis and does demonstrate an age-related decline in lumbar spine bone mineral density. FUTURE DIRECTIONS Application of similar custom region of interest analysis programs to human clinical DXA scans to assess if this improves the diagnostic sensitivity by excluding the spurious elevation of BMD due to degenerative spinal arthritis. KEY WORDS Osteoporosis, age-related, bone density