EFFECT OF ADVANCING AGE ON BONE MINERAL CONTENT OF FEMALE RHESUS MONKEY

年龄增长对雌性恒河猴骨矿物质含量的影响

• 批准号: 6116410
• 负责人: NEIL C BINKLEY
• 金额: $ 5.85万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116410
• 关键词: aging; radiology; skeletal system

OBJECTIVE To assess the effect of advancing age upon bone mass as measured by dual energy x ray absorptiometry. RESULTS While age-related bone loss in humans is well established, the effect of advancing age and menopausal status upon bone density in non-human primates is not. We have previously been unable to demonstrate "age-related" loss cross sectionally. It is possible that this is the result of the standard laboratory chow diet which is very high in calcium and vitamin D by human standards. FUTURE DIRECTIONS We will assess age related skeletal changes in bone mass and markers of bone turnover in this cohort of older female monkeys to document the presence or absence of "age related" bone loss. KEY WORDS Osteoporosis, bone density, bone strength FUNDING Geriatrics section discretionary funds PUBLICATIONS Todd, H., Bruner, J., Haffa A., Krueger, D., & Binkley, N. Bone Loss with Natural Menopause and Advancing Age in Female Rhesus Monkeys. 1998 Bone, 23(5 suppl) S508. [A]

目的探讨增龄对骨量的影响。 用双能x射线吸光度测量仪测量。结果，而 与年龄相关的骨丢失在人类中是公认的， 增龄和绝经状态对非人骨密度的影响 灵长类动物则不是。我们之前无法证明 “年龄相关”损失的横截面。有可能这就是 标准实验室饮食的结果，它含有非常高的 以人体标准来看，钙和维生素D。未来的方向，我们将 评估与年龄相关的骨骼骨量变化和骨标记物 这群年龄较大的雌性猴子的更替记录了 是否有“年龄相关”的骨质流失。关键词 骨质疏松症，骨密度，骨强度资助老年医学部分 自由支配基金出版物Todd，H.，Bruner，J.，Haffa A. Krueger，D.和Binkley，N.自然更年期和 雌性恒河猴的增龄现象。1998年骨，23(5支持)S508。 [A]