AGING ON BONE MINERAL CONTENT OF FEMALE RHESUS MONKEY: OSTEOPOROSIS

雌性恒河猴骨矿物质含量的老化：骨质疏松症

• 批准号: 6277695
• 负责人: NEIL C BINKLEY
• 金额: $ 5.66万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277695
• 关键词: Primates; aging; skeletal system

OBJECTIVE: To assess the effect of advancing age upon bone mass as measured by dual energy x-ray absorptiometry. RESULTS While age-related bone loss in humans is well established, the effect of advancing age upon bone density in non-human primates is not. We have previously been unable to demonstrate "age-related" loss cross sectionally. It is possible that this is the result of the standard laboratory chow diet which is very high in calcium and vitamin D by human standards. FUTURE DIRECTIONS We will assess age related skeletal changes in bone mass and markers of bone turnover in this cohort of older female monkeys to document the presence or absence of "age-related" bone loss. Keywords Osteoporosis, bone density, bone strength Funding Geriatrics section discretionary funds

目的：探讨年龄增长对骨量的影响 通过双能X射线吸收测定法测量。 成果的同时 年龄相关的骨质流失在人类中是公认的， 而非人类灵长类动物的骨密度却没有增加。 我们有 以前无法证明“年龄相关”损失交叉 分段。 有可能这是标准的结果 实验室食物饮食中钙和维生素D含量非常高， 人的标准。 未来的方向我们将评估与年龄相关的 骨质量的骨骼变化和骨转换的标志物， 一群年长的雌性猴子，以记录是否存在 “年龄相关”骨质流失。 骨质疏松症，骨密度，骨 拨款老人科酌情拨款