Electrical Impedance Spectroscopy and Imaging

电阻抗光谱和成像

• 批准号: 6232719
• 负责人: ALEXANDER HARTOV
• 金额: $ 18.71万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6232719
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; breast neoplasm /cancer diagnosis; breast neoplasms; clinical research; diagnosis design /evaluation; digital imaging; early diagnosis; female; human subject; human tissue; image enhancement; mammography; neoplastic process; spectrometry; women's health

While X-ray mammography has proven to be a highly sensitive clinical tool which is likely to remain as the primary method of screening for breast cancer, there is room for some significant advances in the type of information that can be presented to the clinical mammographer. Project II hypothesizes that electrical impedance spectroscopy (EIS) imaging can become a valuable clinical technique for detecting and diagnosis breast cancer by providing complementary information to that of x-ray mammography. Data in the literature has repeatedly shown that there is not only significant inherent contrast in the electrical impedance of normal and cancerous breast tissue but also that there is not only significant inherent contrast in the electrical impedance of normal and cancerous breast tissue but also that spectroscopic data can provide information on the functional status of breast tissue that could be used to diagnose benign from malignant abnormalities. Hence, while EIS may be low in overall structural imaging resolution, the high soft tissue contrast and dispersion in the electrical impedance signatures of normal and pathological tissues make a compelling argument for the potential value of EIS in terms characterizing the functional status of the imaged tissue volume through the spatially-resolved spectroscopic information that would be provided-information that is not readily available through other imaging modalities. The specific aims of Project II can be summarized as (1) to develop a multi-channel (up to 128), multi-frequency (10KHs to 5MHz), dual mode (applied current or voltage) data acquisition system and concomitant clinical electrode interface to the breast which facilitates a safe, comfortable, efficiently administered patient examine while optimizing EIS imaging performance, (2) in conjunction with the Computational ore, to develop two and three dimensional EIS image reconstruction capabilities which exploit advanced model-based image reconstruction concepts such as adaptive dual meshing, multi-component objective function minimization, parallel processing, and multi-spectral imaging, (3) to evaluate and optimize EIS imaging system performance in preclinical processing, and multis-spectral imaging, (3) to evaluate and optimize EIS imaging system performance in preclinical studies involving tissue-equivalent phantoms having geometries relevant to breast tissue imaging and (4) in collaboration with the Clinical Core, to not only demonstrate the feasibility of administering EIS breast imaging exams on human subjects but also to initiate an evaluation of the efficacy of EIS breast imaging as a diagnostic tool by correlating results with patients having normal and abnormal mammograms. The work proposed represents a unique synthesis of existing and novel ideas which should lead to important new information/documentation concerning the potential value of EIS in breast cancer detection. Not only is the scientific rationale for pursuing EIS breast imaging strong, but the practical features of (i) ease of use, (ii) low-cost and (iii) non-ionizing interrogation also make the approach extremely attractive.

虽然X光乳房X光照相已被证明是一种高度敏感的临床工具，可能仍将作为乳腺癌筛查的主要方法，但在可向临床乳房X光照相人员提供的信息类型方面仍有一些重大进展的空间。项目二假设电阻抗波谱(EIS)成像可以成为检测和诊断乳腺癌的一种有价值的临床技术，因为它提供了对X光乳房X光照相的补充信息。文献中的数据反复表明，不仅正常和癌组织的电阻抗存在显著的固有对比度，而且不仅正常和癌组织的阻抗具有显著的固有对比度，而且光谱数据可以提供关于乳腺组织的功能状态的信息，可以用于诊断良恶性异常。因此，虽然EIS的整体结构成像分辨率可能较低，但正常组织和病理组织的高软组织对比度和阻抗特征的离散性使得EIS在通过将提供的空间分辨光谱信息表征成像组织体积的功能状态方面的潜在价值具有令人信服的论点--这些信息是通过其他成像方式不易获得的。项目II的具体目标可以概括为(1)开发一种多通道(高达128)、多频率(10 KHs至5 MHz)、双模式(施加电流或电压)的数据采集系统和相伴的临床电极接口，以便于在优化EIS成像性能的同时进行安全、舒适、高效的患者检查；(2)与计算ORE结合，开发利用先进的基于模型的图像重建概念的二维和三维EIS图像重建能力，所述图像重建概念诸如自适应双重网格、多分量目标函数最小化、并行处理和多光谱成像，(3)评估和优化EIS成像系统在临床前处理和多光谱成像方面的性能；(3)在涉及具有与乳腺组织成像相关的几何形状的组织等效模型的临床前研究中评估和优化EIS成像系统的性能；以及(4)与临床核心合作，不仅论证在人体上进行EIS乳腺成像检查的可行性，而且通过将结果与乳房X光照片正常和异常的患者进行关联，启动对EIS乳腺成像作为诊断工具的有效性的评估。拟议的工作代表了现有的和新的想法的独特综合，这些想法应该导致关于EIS在乳腺癌检测中的潜在价值的重要的新信息/文献。不仅因为追求EIS乳房成像的科学基础很强，而且(I)易于使用，(Ii)低成本和(Iii)非电离询问的实用特征也使这种方法非常有吸引力。