Electrical Impedance Spectroscopy and Imaging

电阻抗光谱和成像

• 批准号: 6336448
• 负责人: ALEXANDER HARTOV
• 金额: $ 18.71万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6336448
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; breast neoplasm /cancer diagnosis; breast neoplasms; clinical research; diagnosis design /evaluation; digital imaging; early diagnosis; female; human subject; human tissue; image enhancement; mammography; neoplastic process; spectrometry; women's health

While X-ray mammography has proven to be a highly sensitive clinical tool which is likely to remain as the primary method of screening for breast cancer, there is room for some significant advances in the type of information that can be presented to the clinical mammographer. Project II hypothesizes that electrical impedance spectroscopy (EIS) imaging can become a valuable clinical technique for detecting and diagnosis breast cancer by providing complementary information to that of x-ray mammography. Data in the literature has repeatedly shown that there is not only significant inherent contrast in the electrical impedance of normal and cancerous breast tissue but also that there is not only significant inherent contrast in the electrical impedance of normal and cancerous breast tissue but also that spectroscopic data can provide information on the functional status of breast tissue that could be used to diagnose benign from malignant abnormalities. Hence, while EIS may be low in overall structural imaging resolution, the high soft tissue contrast and dispersion in the electrical impedance signatures of normal and pathological tissues make a compelling argument for the potential value of EIS in terms characterizing the functional status of the imaged tissue volume through the spatially-resolved spectroscopic information that would be provided-information that is not readily available through other imaging modalities. The specific aims of Project II can be summarized as (1) to develop a multi-channel (up to 128), multi-frequency (10KHs to 5MHz), dual mode (applied current or voltage) data acquisition system and concomitant clinical electrode interface to the breast which facilitates a safe, comfortable, efficiently administered patient examine while optimizing EIS imaging performance, (2) in conjunction with the Computational ore, to develop two and three dimensional EIS image reconstruction capabilities which exploit advanced model-based image reconstruction concepts such as adaptive dual meshing, multi-component objective function minimization, parallel processing, and multi-spectral imaging, (3) to evaluate and optimize EIS imaging system performance in preclinical processing, and multis-spectral imaging, (3) to evaluate and optimize EIS imaging system performance in preclinical studies involving tissue-equivalent phantoms having geometries relevant to breast tissue imaging and (4) in collaboration with the Clinical Core, to not only demonstrate the feasibility of administering EIS breast imaging exams on human subjects but also to initiate an evaluation of the efficacy of EIS breast imaging as a diagnostic tool by correlating results with patients having normal and abnormal mammograms. The work proposed represents a unique synthesis of existing and novel ideas which should lead to important new information/documentation concerning the potential value of EIS in breast cancer detection. Not only is the scientific rationale for pursuing EIS breast imaging strong, but the practical features of (i) ease of use, (ii) low-cost and (iii) non-ionizing interrogation also make the approach extremely attractive.

虽然X射线乳房X线摄影已被证明是一种高度敏感的临床工具，可能仍然是筛查乳腺癌的主要方法，但在可提供给临床乳房X线摄影师的信息类型方面仍有一些重大进展的空间。项目II假设电阻抗谱（EIS）成像可以成为一种有价值的临床技术，通过提供补充信息，X射线乳腺摄影检测和诊断乳腺癌。文献中的数据反复表明，不仅在正常和癌性乳腺组织的电阻抗中存在显著的固有对比，而且不仅在正常和癌性乳腺组织的电阻抗中存在显著的固有对比，而且光谱数据可以提供关于乳腺组织的功能状态的信息，其可以用于诊断良性和恶性异常。因此，虽然EIS在整体结构成像分辨率方面可能较低，正常和病理组织的电阻抗特征中的高软组织对比度和分散性为EIS在通过将提供的空间分辨光谱信息表征成像组织体积的功能状态方面的潜在价值提供了令人信服的论据。通过其他成像方式不易获得的信息。项目II的具体目标可以概括为：（1）发展多渠道（最多128个），多频（10 KHs至5 MHz），双模（施加的电流或电压）数据采集系统和伴随的临床电极接口连接到乳房，这有助于安全、舒适、有效地管理患者检查，同时优化EIS成像性能，（2）结合计算矿石，开发二维和三维EIS图像重建能力，其利用先进的基于模型的图像重建概念，例如自适应双重网格化、多分量目标函数最小化、并行处理和多光谱成像，（3）评估和优化临床前处理和多光谱成像中的EIS成像系统性能，（3）评估和优化临床前研究中的EIS成像系统性能，所述临床前研究涉及具有与乳腺组织成像相关的几何形状的组织等效体模，以及（4）与临床核心合作，不仅证明了对人类受试者进行EIS乳腺成像检查的可行性，而且通过将结果与具有正常和异常乳房X线照片的患者相关联来开始评价EIS乳腺成像作为诊断工具的功效。这项工作提出了一个独特的综合现有的和新的想法，这将导致重要的新的信息/文件的潜在价值的EIS在乳腺癌检测。追求EIS乳腺成像的科学原理不仅强大，而且（i）易于使用，（ii）低成本和（iii）非电离询问的实用功能也使该方法极具吸引力。