Electrical Impedance Spectroscopy and Imaging

电阻抗光谱和成像

• 批准号: 7053022
• 负责人: ALEXANDER HARTOV
• 金额: $ 12.57万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7053022
• 关键词: electrical impedance; mammary gland

Data in the literature has consistently shown that there is not only significant inherent contrast in the electrical bioimpedance of normal and neoplastic breast tissue but also that spectroscopic response can provide important functional information. Further, efforts to develop tomographic imaging systems based on electrical impedance have matured to the point where many of its basic principles and practices are well understood. Project II, Electrical Impedance Spectroscopy and Imaging (EIS), has exploited this foundation to target identification of the most promising roles for EIS imaging in the setting of clinical breast care. During the current funding period, it has completed an ambitious effort to construct, deploy and initially evaluate an ultra-fast, multi-channel, multi-frequency imaging system capable of delivering a volumetric breast exam safely, comfortably and efficiently. The system and its prior prototypes have been used in well over 100 clinical sessions in order to (i) establish exam consistency, (ii) identify normative responses in breasts without disease, (iii) explore electrical property variations due to hormonal changes during the menstrual cycle and (iv) evaluate the detection and characterization of screening abnormalities. The driving force for Project II renewal is optimization, validation and thorough evaluation of the most recently installed EIS imaging system which is, by far, the most advanced version of the instrument that is expected to improve considerably the prior encouraging results. The specific aims for continuation include (1) data acquisition and breast interface optimization of electrode density, geometry, and registration for three-dimensional, high frequency EIS breast imaging, (2) software optimization for ultrafast frame-rates, multi-tone testing, virtual current drive along with three-dimensional high frequency image reconstruction, (3) development, validation and utilization of a probe-based measurement system suitable for studies of EIS-imaged breast tissues at the time of surgical resection, and (4) participation in clinical studies conducted through the Clinical Core which target screening abnormalities recommended for biopsy, palpable masses on clinical breast exams and locally-advanced cancers receiving neoadjuvant therapy. If successful, it is expected that these aims will generate sufficient evidence to allow convincing estimates of the potential of EIS breast imaging as an alternative for differential diagnosis and pilot data in support of a role in treatment prognosis and therapy monitoring to be made which would inform decisions on the initiation of multi-center trials with the technology in the future.

文献中的数据一致表明，不仅存在显着的内在对比 正常和肿瘤性乳腺组织的电生物阻抗，而且光谱响应也可以 提供重要的功能信息。此外，努力开发基于 电阻抗已经成熟到很多基本原理和实践都很好的地步 明白了。项目 II，电阻抗光谱和成像 (EIS)，利用了这一基础 旨在确定 EIS 成像在临床乳腺护理中最有前途的作用。 在当前的资助期内，它已经完成了雄心勃勃的建设、部署和初步工作 评估超快速、多通道、多频率成像系统，该系统能够提供体积 安全、舒适、高效的乳房检查。该系统及其先前的原型已在良好的环境中使用 超过 100 次临床课程，以便 (i) 建立考试一致性，(ii) 确定规范性反应 没有疾病的乳房，（iii）探索由于荷尔蒙变化而导致的电特性变化 月经周期和（iv）评估筛查异常的检测和表征。驾驶 项目 II 更新的动力是对最近安装的优化、验证和彻底评估 EIS 成像系统是迄今为止最先进的仪器版本，预计将 大大改善先前令人鼓舞的结果。延续的具体目标包括（1）数据 电极密度、几何形状和三维配准的采集和乳房界面优化， 高频 EIS 乳腺成像，(2) 针对超快帧速率、多色调的软件优化 测试，虚拟电流驱动以及三维高频图像重建，(3) 开发、验证和利用适用于 EIS 成像研究的基于探针的测量系统 手术切除时的乳腺组织，以及 (4) 参与进行的临床研究 通过临床核心，针对活检建议的筛查异常、可触及的肿块 临床乳房检查和接受新辅助治疗的局部晚期癌症。如果成功的话就是 预计这些目标将产生足够的证据，以便对潜力进行令人信服的估计 EIS 乳腺成像作为鉴别诊断的替代方案和支持治疗作用的试点数据 进行预后和治疗监测，这将为启动多中心治疗的决策提供信息 未来对该技术进行试验。