Cryosurgery with Electrical Impedance Tomography

电阻抗断层扫描冷冻手术

• 批准号: 6337677
• 负责人: ALEXANDER HARTOV
• 金额: $ 9.47万
• 依托单位: HANOVER MEDICAL IMAGING PROJECT, LLC
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-15 至 2001-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6337677
• 关键词: biomedical equipment development; computer program /software; computer system design /evaluation; cryoscience; cryosurgery; electrical impedance; electrodes; necrosis; phantom model; tomography

Cryosurgery consists of deep-freezing tissue in situ to destroy, manipulate or change its structure. It is only recently that cryosurgery has gained popularity as a minimally invasive procedure, thanks to the advances in modern imaging systems. Its use in deep soft tissues and on superficial lesions has been extensively documented and its effectiveness well established. The remaining obstacle to its more widespread use resides in estimating the extent of the ice ball during procedures and estimating the extent of necrosis. Immediately following cryosurgery. This has resulted in a slow adoption of its use, particularly in the US. We propose to combine cryosurgery with impedance measurements to obtain an accurate assessment of the size and shape of the ice ball during cryosurgery. A custom cryoprobe will be designed which will allow impedance measurements to be made during a procedure. In addition, an existing impedance analyzer will be used under computer control to perform the measurements in real time and reconstruct the ice ball shape and size using the impedance recorded. Finally a series of experiments in tissue- mimicking phantoms will be conducted to evaluate the system's capability in gauging the size and shape of the ice ball. PROPOSED COMMERCIAL APPLICATIONS: The remaining obstacle to the more widespread use of cryosurgery resides in estimating the extent of the ice ball during deep procedures and estimating the extent of necrosis immediately following cryosurgery. This has resulted in a slow adoption of its user, particularly in the US. We proposed to combine cryosurgery with Electrical Impedance Tomography (EIT) to obtain an accurate assessment of the size and shape of the ice ball during cryosurgical procedures. Hanover Medical Imaging Project LLC hopes to develop an effective method to accurately monitor the size of cryolesions. This collaboration between Hanover Medical Imaging Project LLC and CryoFlex, Inc., a firm that manufactures and distributes cryosurgery equipment may result in a very significant competitive advantage in the marketing of their devices. The integration of EIT capabilities with their existing equipment would constitutive a unique and possible very significant improvement in the current state of the art in cryosurgery.

冷冻手术包括原位深度冷冻组织以破坏、操纵或改变其结构。直到最近，由于现代成像系统的进步，冷冻手术作为一种微创手术才得到普及。它在深层软组织和浅表病变上的使用已被广泛记录，其有效性已得到证实。其更广泛应用的障碍在于在手术过程中估计冰球的范围和估计坏死的程度。冷冻手术后立即。这导致了对其使用的缓慢接受，尤其是在美国。我们建议将冷冻手术与阻抗测量相结合，以便在冷冻手术期间准确评估冰球的大小和形状。将设计一个定制的冷冻探头，以便在手术过程中进行阻抗测量。此外，现有的阻抗分析仪将在计算机控制下进行实时测量，并根据记录的阻抗重建冰球的形状和大小。最后，将在组织模拟模型中进行一系列实验，以评估该系统在测量冰球大小和形状方面的能力。建议的商业应用：冷冻手术更广泛应用的剩余障碍在于在深度手术中估计冰球的范围和在冷冻手术后立即估计坏死的范围。这导致其用户接受速度缓慢，尤其是在美国。我们建议将冷冻手术与电阻抗断层扫描（EIT）相结合，以便在冷冻手术过程中准确评估冰球的大小和形状。汉诺威医学成像项目有限责任公司希望开发一种有效的方法来准确监测冷冻创口的大小。汉诺威医学成像项目有限责任公司和CryoFlex， Inc.（一家制造和分销冷冻手术设备的公司）之间的合作可能会在其设备的营销中产生非常显著的竞争优势。EIT能力与他们现有设备的整合将构成一个独特的，可能非常显著的改进，在冷冻手术的艺术目前的状态。