47T HORIZONTAL BORE NMR UPGRADE

47T 水平孔径核磁共振升级

• 批准号: 2802994
• 负责人: IOANNIS CONSTANTINIDIS
• 金额: $ 36万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-15 至 2001-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2802994
• 关键词: bioimaging /biomedical imaging; biomedical equipment; biomedical equipment purchase; magnetic resonance imaging; nuclear magnetic resonance spectroscopy

We request the upgrade of a 33 cm horizontal bore 4.7T NMR instrument to cell and animal research. This instrument was purchase in 1989 and has not been upgraded since. Although it has been very useful, it is now obsolete. At present, its operating software and hardware are incapable of performing routine oblique T1 or T2 weighted multi-slice imaging, and switching of nuclei involves the manual exchange of 1/4 and 1/2 wavelength cables. The proposed upgrade will provide us with a state-of- the-art instrument that will have shielded gradients, higher gradient strength, and electronic switching between nuclei. As a result of the upgrade we will be able to execute even the most demanding imaging sequences, improving our image resolution and spectroscopy localization, and performing multi-nuclear interleaved experiments. These capabilities are not possible with our present configuration. The upgraded instrument will have 4 major and 2 minor users with diverse research interests ranging from the acquisition of high resolution images and localized spectra in rodents to 3D chemical shift imaging and interleaved spectroscopy in perfused cell preparations. Since this is the only instrument of its kind in the State of Georgia, upgrading it is essential for the successful continuation of our research. The benefits from this upgrade will be immediate and long lasting. The instrument will be staffed by the Frederick Philips Magnetic Resonance Research Center, an integral part of an effort by the Department of Radiology at Emory University to create a comprehensive state-of-the-art imaging research facility that includes Magnetic Resonance Imaging/Spectroscopy and PET. This facility is already available to investigators within Emory University and other neighboring academic institutions as well as to industry.

我们要求将一台33厘米水平孔4.7T核磁共振仪升级，用于细胞和动物研究。该仪器于1989年购买，此后一直没有升级。虽然它非常有用，但现在已经过时了。目前，其操作软件和硬件不能进行常规的斜向T1或T2加权多层成像，并且核的切换涉及1/4和1/2波长电缆的手动交换。拟议的升级将为我们提供一个最先进的仪器，将有屏蔽梯度，更高的梯度强度，和电子之间的原子核切换。升级后，我们将能够执行最苛刻的成像序列，提高图像分辨率和光谱定位，并执行多核交错实验。这些功能在我们目前的配置下是不可能实现的。升级后的仪器将有4个主要用户和2个次要用户，他们具有不同的研究兴趣，从啮齿动物的高分辨率图像和局部光谱的获取到灌注细胞制备中的3D化学位移成像和交错光谱。由于这是格鲁吉亚州唯一的此类仪器，因此对其进行升级对于我们继续成功开展研究至关重要。这次升级带来的好处将是即时和持久的。该仪器将由Frederick Philips磁共振研究中心配备人员，该中心是Emory大学放射学系努力创建一个综合性最先进的成像研究设施的一个组成部分，该设施包括磁共振成像/光谱学和PET。该设施已经提供给埃默里大学和其他邻近学术机构以及工业界的调查人员。