47T HORIZONTAL BORE NMR UPGRADE

47T 水平孔径核磁共振升级

• 批准号: 2802994
• 负责人: IOANNIS CONSTANTINIDIS
• 金额: $ 36万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-15 至 2001-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2802994
• 关键词: bioimaging /biomedical imaging; biomedical equipment; biomedical equipment purchase; magnetic resonance imaging; nuclear magnetic resonance spectroscopy

We request the upgrade of a 33 cm horizontal bore 4.7T NMR instrument to cell and animal research. This instrument was purchase in 1989 and has not been upgraded since. Although it has been very useful, it is now obsolete. At present, its operating software and hardware are incapable of performing routine oblique T1 or T2 weighted multi-slice imaging, and switching of nuclei involves the manual exchange of 1/4 and 1/2 wavelength cables. The proposed upgrade will provide us with a state-of- the-art instrument that will have shielded gradients, higher gradient strength, and electronic switching between nuclei. As a result of the upgrade we will be able to execute even the most demanding imaging sequences, improving our image resolution and spectroscopy localization, and performing multi-nuclear interleaved experiments. These capabilities are not possible with our present configuration. The upgraded instrument will have 4 major and 2 minor users with diverse research interests ranging from the acquisition of high resolution images and localized spectra in rodents to 3D chemical shift imaging and interleaved spectroscopy in perfused cell preparations. Since this is the only instrument of its kind in the State of Georgia, upgrading it is essential for the successful continuation of our research. The benefits from this upgrade will be immediate and long lasting. The instrument will be staffed by the Frederick Philips Magnetic Resonance Research Center, an integral part of an effort by the Department of Radiology at Emory University to create a comprehensive state-of-the-art imaging research facility that includes Magnetic Resonance Imaging/Spectroscopy and PET. This facility is already available to investigators within Emory University and other neighboring academic institutions as well as to industry.

我们要求将33厘米水平孔4.7T NMR仪器升级到细胞和动物研究。该乐器是在1989年购买的，此后一直没有升级。尽管它非常有用，但现在已经过时了。目前，其操作软件和硬件无法执行常规的倾斜T1或T2加权多切片成像，而核的切换涉及1/4和1/2波长电缆的手动交换。拟议的升级将为我们提供一种最先进的仪器，该仪器将具有屏蔽梯度，更高的梯度强度以及核之间的电子切换。通过升级，我们将能够执行最苛刻的成像序列，改善我们的图像分辨率和光谱定位，并进行多核交织的实验。我们目前的配置无法使用这些功能。升级的仪器将拥有4位主要和2个次要使用者，具有不同的研究兴趣，从啮齿动物中的高分辨率图像和局部光谱到3D化学移位成像和灌注细胞制剂中的相互交流光谱。由于这是佐治亚州唯一同类工具，因此升级对于成功延续我们的研究至关重要。这次升级的好处将立即持久。该仪器将由弗雷德里克·飞利浦（Frederick Philips）磁共振研究中心组成，这是埃默里大学（Emory University）放射学系不可或缺的一部分，以创建一个全面的最先进的成像研究设施，其中包括磁共振成像/光谱/光谱和宠物。埃默里大学（Emory University）和其他邻近学术机构以及行业的研究人员已经可以使用此设施。