CONFINEMENT OF OPTICAL EXCITATION BY SUB WAVELENGTH HOLES IN METAL FILMS

CaI 2+波以极化方式在单个肝细胞中传播。 时尚. 虽然对IP3敏感的Ca2+商店集中在 心尖区CaI 2+波是否开始尚不清楚; 也不知道哪些信使分子负责Ca2 + 在肝细胞的其他地方释放。 Ca2+的增加也会诱导 肝细胞的顶端收缩，这可能是导致 胆汁的蠕动有助于维持分泌。 但 Cai~（2+）波在调节泪小管收缩中的作用也是 未知 这项合作涉及多光子的优化 释放NPE-IP3，用于研究 Cai 2+波在肝细胞中的起始和传播。

Cai2+ waves spread across individual hepatocytes in a polarized fashion. Although Ca2+ stores sensitive to IP3 are concentrated in the apical region, it is unclear whether Cai2+ waves begin apically; nor is it known which messenger molecules are responsible for Ca2+ release elsewhere in the hepatocyte. Increased Cai2+ also induces apical contractions in hepatocytes, which may be responsible for the peristaltic flow of bile that helps maintain secretion. However, the role of Cai2+ waves in regulating canalicular contraction also is unknown. This collaboration involves the optimization of multiphoton uncaging of NPE-IP3 for use in experiments designed to study the initiation and propagation of Cai2+ waves in hepatocytes.