CONFINEMENT OF OPTICAL EXCITATION BY SUB WAVELENGTH HOLES IN METAL FILMS

金属薄膜中亚波长孔对光学激发的限制

• 批准号: 6349433
• 负责人: MICHAEL LEVENE
• 金额: $ 2.47万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6349433
• 关键词: animal tissue; bioengineering /biomedical engineering; biomedical resource; human tissue; lasers; lipids; liver

Cai2+ waves spread across individual hepatocytes in a polarized fashion. Although Ca2+ stores sensitive to IP3 are concentrated in the apical region, it is unclear whether Cai2+ waves begin apically; nor is it known which messenger molecules are responsible for Ca2+ release elsewhere in the hepatocyte. Increased Cai2+ also induces apical contractions in hepatocytes, which may be responsible for the peristaltic flow of bile that helps maintain secretion. However, the role of Cai2+ waves in regulating canalicular contraction also is unknown. This collaboration involves the optimization of multiphoton uncaging of NPE-IP3 for use in experiments designed to study the initiation and propagation of Cai2+ waves in hepatocytes.

ca2 +波以极化的方式在单个肝细胞间传播