EFFECTS OF AGE & BODY COMPOSITION ON SERUM LEPTIN LEVELS IN RHESUS MONKEYS

年龄的影响

• 批准号: 6116416
• 负责人: RICKI J COLMAN
• 金额: $ 5.85万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116416
• 关键词: Mammalia; aging; endocrine gland /system; nutrition; nutrition related tag; radiology

OBJECTIVE To assess the effect of advancing age upon the relationship between leptin and body fat in rhesus monkeys. RESULTS In rhesus monkeys, as in humans, leptin is positively correlated with body fat content, however, this relationship changes with advancing age. DISCUSSION Serum leptin concentration is positively correlated with body fat content. The effect of advancing age upon the relationship between leptin and body fat is not well known. In this experiment, 115 adult rhesus macaques (60 females, 55 males) ranging in age from 4 to 34 years old were evaluated for body composition and leptin concentrations. Body composition was determined by dual-energy X-ray absorptiometry. Serum leptin was measured in single fasted morning blood samples. Results indicate no sex difference in the way age interacts with leptin and body fat, allowing sexes to be pooled for further analysis. Pearson product moment correlations showed leptin to be highly correlated with indices of body fat (total fat, r=0.802; %fat, r=0.783; abdominal fat, r=0.801; thoracic fat, r=0.778). Multiple regression analysis showed an increase in leptin with age(p=0.0008), and an interaction between leptin and total body fat with age (p=0.006). This study confirms previous findings of a close relationship between circulating leptin levels and indices of body fat. In addition, this experiment shows that in rhesus monkeys, the relationship between leptin and body fat is not influenced by gender, but does change with advancing age. FUTURE DIRECTIONS We plan to continue using DXA and leptin to better characterize body composition in rhesus monkeys, and to continue to explore the relationship between body composition and leptin at different ages. KEY WORDS fat tissue mass, body fat distribution, DXA FUNDING NIH PO1 AG11915 PUBLICATIONS Colman RJ, Ramsey JJ, Kemnitz JW. The effects of age and body composition on serum leptin levels in rhesus macaques. Gerontol 38(1):15, 1998.

目的评估年龄增长对老年人 猕猴瘦素与体脂的关系 结果 在恒河猴中，就像在人类中一样，瘦素与 然而，这种关系随着年龄的增长而变化。 年龄 血清瘦素浓度与肥胖呈正相关 身体脂肪含量。 年龄增长对 瘦素与体脂的关系尚不清楚。 在这 实验中，115只成年恒河猴（60只雌性，55只雄性）， 年龄从4岁到34岁， 瘦素浓度 采用双能法测定体成分 X线吸收测定法 测定空腹 早上的血液样本。 结果表明，在这方面没有性别差异 年龄与瘦素和身体脂肪相互作用，允许性别合并 以供进一步分析。 Pearson积差相关显示， 瘦素与体脂肪指数（总脂肪， r=0.802; %脂肪，r=0.783;腹部脂肪，r=0.801;胸部脂肪， r=0.778）。 多元回归分析显示， 与年龄（p=0.0008），以及瘦素和全身之间的相互作用 脂肪随年龄增长（p=0.006）。 这项研究证实了以前的发现， 循环瘦素水平和指标之间的密切关系， 身体脂肪 此外，这个实验表明，在恒河猴中， 瘦素和体脂肪之间的关系不受 性别，但随着年龄的增长而变化。 未来的方向我们计划 继续使用DXA和瘦素，以更好地表征身体 恒河猴的组成，并继续探索 不同年龄体成分与瘦素的关系。 关键词脂肪组织质量，体脂分布，DXA基金NIH PO 1 出版物Colman RJ，Ramsey JJ，Kemnitz JW. 的影响 年龄和体成分对恒河猴血清瘦素水平的影响 Gerontol 38（1）：15，1998.