EFFECTS OF AGE & BODY COMPOSITION ON SERUM LEPTIN LEVELS IN RHESUS MONKEYS

目的探讨增龄对老年人心理健康的影响。 猕猴体内瘦素与体脂的关系。结果 在恒河猴中，就像在人类中一样，瘦素与 然而，身体脂肪含量，这种关系随着时间的推移而改变。 年龄。讨论血清瘦素水平与血清瘦素水平呈正相关 身体脂肪含量。年龄增长对老年人心理健康的影响 瘦素和体脂之间的关系还不是很清楚。在这 实验中，成年恒河猴115只(雌性60只，雄性55只)不等 在4岁到34岁之间进行了身体成分和 瘦素浓度。身体成分由双能量决定。 X射线吸光度测定法。空腹一次测定血清瘦素 早上的血样。结果表明，这一方式没有性别差异。 年龄与瘦素和体脂相互作用，使性别得以融合 以作进一步分析。皮尔逊积矩相关性显示 瘦素与体脂指数高度相关(总脂肪， R=0.802；%脂肪，r=0.783；腹脂，r=0.801；胸脂， R=0.778)。多元回归分析显示瘦素增加 随着年龄的增长(p=0.0008)，瘦素与全身的相互作用 肥胖随年龄增长(p=0.006)。这项研究证实了之前的发现 循环瘦素水平与糖尿病相关指标的关系 身体脂肪。此外，这项实验表明，在恒河猴身上， 瘦素和体脂的关系不受 性别，但确实会随着年龄的增长而变化。我们计划的未来方向 继续使用DXA和瘦素来更好地描述身体 组成恒河猴，并继续探索 不同年龄组体成分与瘦素的关系 关键词脂肪组织质量、体脂分布、DXA资助NIH PO1 AG11915出版物：Colman RJ，Ramsey JJ，Kemnitz JW。的影响 猕猴年龄和体成分对血清瘦素水平的影响。 Gerontol 38(1)：15,1998。

OBJECTIVE To assess the effect of advancing age upon the relationship between leptin and body fat in rhesus monkeys. RESULTS In rhesus monkeys, as in humans, leptin is positively correlated with body fat content, however, this relationship changes with advancing age. DISCUSSION Serum leptin concentration is positively correlated with body fat content. The effect of advancing age upon the relationship between leptin and body fat is not well known. In this experiment, 115 adult rhesus macaques (60 females, 55 males) ranging in age from 4 to 34 years old were evaluated for body composition and leptin concentrations. Body composition was determined by dual-energy X-ray absorptiometry. Serum leptin was measured in single fasted morning blood samples. Results indicate no sex difference in the way age interacts with leptin and body fat, allowing sexes to be pooled for further analysis. Pearson product moment correlations showed leptin to be highly correlated with indices of body fat (total fat, r=0.802; %fat, r=0.783; abdominal fat, r=0.801; thoracic fat, r=0.778). Multiple regression analysis showed an increase in leptin with age(p=0.0008), and an interaction between leptin and total body fat with age (p=0.006). This study confirms previous findings of a close relationship between circulating leptin levels and indices of body fat. In addition, this experiment shows that in rhesus monkeys, the relationship between leptin and body fat is not influenced by gender, but does change with advancing age. FUTURE DIRECTIONS We plan to continue using DXA and leptin to better characterize body composition in rhesus monkeys, and to continue to explore the relationship between body composition and leptin at different ages. KEY WORDS fat tissue mass, body fat distribution, DXA FUNDING NIH PO1 AG11915 PUBLICATIONS Colman RJ, Ramsey JJ, Kemnitz JW. The effects of age and body composition on serum leptin levels in rhesus macaques. Gerontol 38(1):15, 1998.