EFFECT OF DIETARY RESTRICTION ON BONE MINERAL CONTENT OF RHESUS MONKEYS

饮食限制对恒河猴骨矿物质含量的影响

• 批准号: 6116415
• 负责人: RICKI J COLMAN
• 金额: $ 5.85万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116415
• 关键词: Mammalia; aging; arthritis; bioimaging /biomedical imaging; endocrine gland /system; nutrition; nutrition related tag; radiography; radiology; skeletal system

OBJECTIVE To assess the effect of dietary restriction and aging upon bone metabolism in rhesus monkeys. RESULTS Bone mass was lower in dietary restricted animals, however this reflects smaller body size and not pathological osteopenia. In addition, dietary restriction may protect against the development of spinal osteoarthritis. DISCUSSION The pathogenesis of age-related bone loss is unclear. As dietary restriction (DR) retards many aspects of aging, it may also alter skeletal changes. The purpose of this study was to examine the effects of moderate DR (30% reduction in caloric intake from individual baseline values) on bone. Bone mass (dual-energy X-ray absorptiometry), turnover (osteocalcin, ICTP, and NTx) and lumbar spine osteoarthritis (OA; radiographs) were examined longitudinally in male (15 Control [C], 15 Restricted [R]; after 96 months of DR) rhesus macaques 8-14 years of age at the onset of DR. Total body bone mass was lower in R compared to C males and females. In the females, R bone mass was also lower than C at the posterior-anterior spine and radius (except for distal radius bone mineral content). Serum turnover markers, and calcium and phosphorus concentration were not different between C and R groups. In addition, testosterone and FSH in the males were unchanged. There was less evidence of spi nal OA in R males. We believe the lower bone mass reflects the smaller body size, and not pathological osteopenia. In this model, DR does not cause deleterious endocrine effects and may afford protection against spinal OA. FUTURE DIRECTIONS We plan to continue using DXA, radiographs and markers of bone metabolism to better characterize the skeletal aging process in rhesus monkeys, making them better understood models for osteoporosis research. KEY WORDS osteoporosis, bone density, aging, bone metabolism, DXA FUNDING NIH PO1 AG11915

摘要目的评价饮食限制与老龄化的关系。 对恒河猴骨骼代谢的影响。结果骨量较低 然而，在饮食受限的动物中，这反映了较小的身体尺寸。 而不是病理性的骨量减少。此外，饮食限制可能 防止脊柱骨关节炎的发展。讨论 年龄相关性骨丢失的发病机制尚不清楚。作为膳食 限制(DR)延缓衰老的许多方面，它也可能改变 骨骼的变化。这项研究的目的是检查 中度DR的效果(将卡路里摄入量从 个体基线值)。骨量(双能X射线 骨吸收测定)、周转(骨钙素、ICTP和NTX)和腰椎 脊椎骨关节炎(骨性关节炎)的纵向检查。 雄性(15只对照[C]，15只受限[R]；96个月DR后)恒河猴 8-14岁猕猴开始时全身总骨量 与C男性和女性相比，R更低。在雌性中，R 骨量也低于C在后-前棘和 桡骨(除桡骨远端骨矿含量外)。血清 周转标志物、钙和磷浓度没有 C组和R组之间存在差异。此外，睾酮和卵泡刺激素 在雄性中没有变化。有更少的证据表明SPI-NAL在 R男性。我们认为，较低的骨量反映了较小的身体 大小，而不是病理性骨量减少。在此模型中，DR不 引起有害的内分泌影响，并可能提供保护 脊椎骨关节炎。未来方向我们计划继续使用DXA， X线片和骨代谢标志物，以更好地描述 恒河猴的骨骼老化过程，使它们变得更好 了解骨质疏松症研究的模型。关键词骨质疏松症 骨密度、衰老、骨代谢，DXA资助NIH PO1 AG11915