SPECIFIC PATHOGEN FREE MACAQUE BREEDING & RESEARCH PROGRAM

NERPRC的SPF计划是富有成效的， 1998年，我们纳入了40个育种年龄， 雌性和8只育龄雄性，进入我们的SPF定时交配群体 我们有75只2岁和3岁的第二代SPF动物， 已经被确定为替代育种者， 确定另外50只1998年出生的动物， 定期对所有动物进行筛查， 靶向逆转录病毒和B病毒是维持和衍生的关键 SPF育种群筛选已建立的育种群 每半年一次，除非因意外原因需要进行更频繁的检测 NERPRC SPF群体经历了高的临床疾病 1998年的怀孕率为 大约60%有20个稳定的后宫集团和12个小的 所有雌性定时交配组建立新的后宫组， 空间允许小的野兔被招募到定时交配的群体中， 最大化空间SPF繁殖群体每年评估一次， 或非生产性动物被分配到其他研究

The NERPRC SPF program is productive and has remained pathogen-free for eight years In 1998, we incorporated 40 breeding age females and eight breeding age males, into our SPF timed-mating colony We have 75 two and three year old second generation, SPF animals that have been identified as replacement breeders and anticipate identifying an additional 50 animals born in 1998 to serve as replacement breeders Regular screening of all animals for the three target retroviruses and B Virus is the key to maintaining and deriving SPF breeding groups Established breeding groups are screened semiannually unless more frequent testing is warranted by unexpected clinical illness in the group The NERPRC SPF colony experiences high fertility and minimal fighting The pregnancy rate in 1998 was approximately 60% There are 20 stable harem groups and twelve small all female timed-mating groups New harem groups are established as space allows Small harems are recruited into timed-mating groups to maximize space The SPF breeding colony is evaluated annually and older or unproductive animals are assigned to other studies