SPECIFIC PATHOGEN FREE MACAQUE BREEDING AND RESEARCH PROGRAM

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The NEPRC SPF program is very productive and has remained specific pathogen-free for the past nine years. All of the animals in the groups stayed pathogen free. There are currently approximately 500 animals in breeding harem groups. The breeding groups consist of a maximum of 10 females and 1 adult male. The breeding program at the NEPRC consists of specific pathogen free animals with Herpes B antibody negative animals only. Regular screening of all animals both adults and juveniles for the target retroviruses is a key to maintaining and deriving SPF breeding group. Established groups are screened at least semi-annually unless more frequent testing is warranted by an unexpected clinical illness in the colony.