SPECIFIC PATHOGEN FREE MACAQUE BREEDING AND RESEARCH PROGRAM

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。NEPRC SPF计划非常有效，在过去的九年中一直保持无特定病原体。各组中的所有动物都保持无病原体状态。目前大约有500只动物在繁殖后宫群。繁殖组最多由10只雌性和1只成年雄性组成。NEPRC的育种计划仅包括无特定病原体的B型疱疹抗体阴性动物。定期对所有动物（包括成年和幼年动物）进行目标逆转录病毒筛查是维持和获得SPF繁殖群的关键。已建立的群体至少每半年进行一次筛查，除非群体中出现意外的临床疾病需要更频繁的检测。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The NEPRC SPF program is very productive and has remained specific pathogen-free for the past nine years. All of the animals in the groups stayed pathogen free. There are currently approximately 500 animals in breeding harem groups. The breeding groups consist of a maximum of 10 females and 1 adult male. The breeding program at the NEPRC consists of specific pathogen free animals with Herpes B antibody negative animals only. Regular screening of all animals both adults and juveniles for the target retroviruses is a key to maintaining and deriving SPF breeding group. Established groups are screened at least semi-annually unless more frequent testing is warranted by an unexpected clinical illness in the colony.