SPECIFIC PATHOGEN FREE MACAQUE BREEDING & RESEARCH PROGRAM

无特定病原体猕猴育种

• 批准号: 6453810
• 负责人: PRABHAT K SEHGAL
• 金额: $ 11.11万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6453810
• 关键词: AIDS; Mammalia; communicable diseases; immunology; inflammation; lymphatic system; reproductive system; virus

The NERPRC SPF program is productive and has remained pathogen-free for eight years In 1998, we incorporated 40 breeding age females and eight breeding age males, into our SPF timed-mating colony We have 75 two and three year old second generation, SPF animals that have been identified as replacement breeders and anticipate identifying an additional 50 animals born in 1998 to serve as replacement breeders Regular screening of all animals for the three target retroviruses and B Virus is the key to maintaining and deriving SPF breeding groups Established breeding groups are screened semiannually unless more frequent testing is warranted by unexpected clinical illness in the group The NERPRC SPF colony experiences high fertility and minimal fighting The pregnancy rate in 1998 was approximately 60% There are 20 stable harem groups and twelve small all female timed-mating groups New harem groups are established as space allows Small harems are recruited into timed-mating groups to maximize space The SPF breeding colony is evaluated annually and older or unproductive animals are assigned to other studies

NERPRC SPF 计划富有成效，并且一直保持 八年无病原体 1998年，我们纳入了40个繁殖年龄 雌性和八只繁殖年龄的雄性进入我们的 SPF 定时交配群体 我们有 75 只两岁和三岁的第二代 SPF 动物 已被确定为替代育种者并预计 确定另外 50 只出生于 1998 年的动物作为 替代饲养员定期对所有动物进行三项筛查 靶向逆转录病毒和B病毒是维持和衍生的关键 SPF 育种群体 筛选已建立的育种群体 每半年进行一次，除非由于意外情况需要更频繁的测试 NERPRC SPF 群体的临床疾病经历了高 生育力和最少的战斗 1998 年的怀孕率为 大约60% 有20个稳定的后宫团体和12个小团体 所有女性定时交配群体 新的后宫群体建立为 空间允许 小后宫被招募到定时交配群体中 最大化空间 SPF 繁殖群体每年进行一次评估 或非生产性动物被分配到其他研究