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NOVEL METABOLIC INPUTS INTO SYNTHESIS OF THIAMINE IN S TYPHIMURIUM

NOVEL METABOLIC INPUTS INTO SYNTHESIS OF THIAMINE IN S TYPHIMURIUM
鼠伤寒沙门氏菌中硫胺素合成的新代谢输入
批准号:
6298146
负责人:
Diana M. Downs
金额:
$0.75万
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-03-01 至 2000-02-29

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英文摘要
Our work focuses on the thiamine biosynthetic pathway in Salmonella typhimurium. We have currently found two novel metabolic inputs into the synthesis of the pyrimidine moiety of thiamine which was reportedly derived from de novo purine biosynthesis. Our current work focuses on determining the genes and gene products involved in the alternative pyrimidine biosynthetic pathway (APB) we have described. We foresee this work requiring structural determination of various metabolites we isolate from mutants affecting thiamine synthesis. One step in this structural determination will be the NMR spectral determination carried out by NMRFAM.
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The RidA examine deaminase links metabolism with virulence in Campylobacter jejuni
  • 批准号:
    10204983
  • 项目类别:
  • 资助金额:
    $18.88万
  • 财政年份:
    2020
  • 负责人:
    Diana M. Downs
  • 依托单位:
The RidA examine deaminase links metabolism with virulence in Campylobacter jejuni
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    10039719
  • 项目类别:
  • 资助金额:
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  • 财政年份:
    2020
  • 负责人:
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Rid family members neutralize endogenous metabolic stressors
  • 批准号:
    10469647
  • 项目类别:
  • 资助金额:
    $33.07万
  • 财政年份:
    2011
  • 负责人:
    Diana M. Downs
  • 依托单位:
Rid family members neutralize endogenous metabolic stressors
  • 批准号:
    10673400
  • 项目类别:
  • 资助金额:
    $4.39万
  • 财政年份:
    2011
  • 负责人:
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  • 依托单位:
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