INVESTIGATION OF CLINICAL AND HORMONAL EFFECTS OF GHRP2 SUBCUTANEOUSLY

GHRP2 皮下临床和激素影响的研究

• 批准号: 6298257
• 负责人: CYRIL Y BOWERS
• 金额: $ 1.97万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6298257
• 关键词: binding proteins; clinical research; clinical trials; drug administration routes; drug screening /evaluation; endocrine pharmacology; growth hormone releasing hormone; hormone biosynthesis; hormone therapy; human subject; insulinlike growth factor; secretion; somatotropin; synthetic peptide

The purpose of this study will be to assess whether GHRP-2 administered subcutaneously by 4 consecutive injections or by infusion stimulates growth hormone secretion. Additionally the study will seek to determine if the insulin IGF-1 and IGFBP-3 increases. This trial will be conducted in approximately 16 adults aged 20-80 years old. GHRP-2 is a pure synthetic small peptide which specifically releases growth hormone from the pituitary. GHRP-2 is made up of a varying number of amino acids. The effect of GHRP-2 on the acute release of growth hormone is important because this may become a specific alternate method of increasing growth hormone in man.

本研究的目的将是评估是否GHRP-2管理 皮下连续注射4次或输注刺激 生长激素分泌 此外，该研究将寻求确定 如果胰岛素IGF-1和IGFBP-3增加。 这次审判将在 大约16名年龄在20-80岁之间的成年人。GHRP-2是一种纯 合成小肽，其特异性地从 脑垂体 GHRP-2由不同数量的氨基酸组成。 GHRP-2对生长激素急性释放的影响是重要的 因为这可能会成为一种特定的替代方法， 人体内的荷尔蒙