Does the potential for AMR selection differ between common UK cattle grazing systems?
英国常见牛放牧系统之间 AMR 选择的潜力是否有所不同?
基本信息
- 批准号:NE/N019792/1
- 负责人:
- 金额:$ 20.54万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2016
- 资助国家:英国
- 起止时间:2016 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Antimicrobial resistance (AMR) occurs because repeated exposure to antimicrobial drugs kills susceptible bacteria leaving the resistant types to multiply. Recent high-profile reports of the devastating consequences for human health caused by the resistance of disease-causing bacteria to antibiotics have emphasized the need to understand the processes that drive increasing prevalence of antimicrobial resistance in human and animal pathogens.Farm animals are considered to be a major source of AMR because of the large amounts of antibiotics used both to treat infection (therapeutic use) and to prevent infection (prophylactic use). However, little is known about the background levels of resistance in farming systems, even when animals are only treated with antibiotics when they need them (therapeutically). For instance, the sharing of genetic material by bacteria that are in close proximity is another route where AMR may emerge unexpectedly in otherwise non-related bacteria. AMR transmission between cattle is likely to be greater when they are close together, for example during the winter housed period. In this proposal we will use an experimental farm where cattle being raised for beef production only receive minimal antibiotic treatment described as 'best practice' by vets. We will monitor dynamics of AMR bacteria and genes in cattle dung in summer when the cattle are grazing in the field, and in the winter when they are housed together. We will carefully monitor cattle who have been sick and have been given antibiotics and those in the rest of the herd.The diet of farm animals may also effect increased AMR in their gut flora. Even common plants ('forage') like grass and clover that cattle commonly eat when they are out grazing produce natural antimicrobial compounds that may continue to be active in the stomach (rumen) where millions of bacteria thrive and multiply. In the winter, cattle are brought indoors and fed silage which is grassland plants that have been fermented to conserve them. Undigested diet and lots of bacteria from the rumen, and therefore perhaps AMR, are excreted in cow dung. We will analyse the dung of cattle that eat different forage types to find out if what they eat affects the likelihood of AMR arising in cattle fed one diet compared to another.Most cattle farming in the UK is situated in the hilly 'wet West' where the potential for rain to runoff fields into waterways is high. Recent increases in storms that cause lots of runoff and flooding may be due to climate change, are predicted to continue. At the same time, in recent years there has been an increasing recognition that AMR may arise in farm animals and be released from the farm environment to the natural environment in water and might therefore end up in drinking water, bathing water or in seafood. Normally, pollution from cattle dung in water is monitored using faecal indicator organisms (FIOs), which are bacteria that do not usually cause disease but which correlate with those that do (pathogens), and can be handled safely by scientists. It would be useful to know what proportion of FIOs carry AMR, because they are routinely tested for, facilitating estimates of AMR transmission to be estimated in the future. We will sample water flowing from fields that have been grazed by beef cattle or spread with their manure, and analyse the bacteria in the water including the FIOs to see if they are resistant to antibiotics.The results of this study should help us to understand whether AMR that arises in cattle herds may be transferred to the environment, whether management can limit AMR and its transport, and inform approaches for assessing risks of new antibiotics and managing adverse effects that might be occurring. It is important work for addressing risk in our complex agro-food system that is clearly important for both consumers and farmers.
抗菌素耐药性(AMR)的发生是因为反复接触抗菌素药物杀死了敏感细菌,使耐药类型繁殖。最近关于致病细菌对抗生素产生耐药性对人类健康造成毁灭性后果的引人注目的报告强调,有必要了解导致人类和动物病原体中抗菌素耐药性日益普遍的过程。农场动物被认为是抗生素耐药性的主要来源,因为用于治疗感染(治疗性使用)和预防感染(预防性使用)的大量抗生素。然而,人们对农业系统中的耐药性背景水平知之甚少,即使动物只在需要抗生素时(治疗性地)使用抗生素。例如,相近的细菌共享遗传物质是另一种途径,抗菌素耐药性可能在其他不相关的细菌中意外出现。当牛靠近时,例如在冬季圈养期间,它们之间的抗菌素耐药性传播可能更大。在这个提议中,我们将使用一个实验农场,在那里饲养的牛肉只接受兽医称之为“最佳实践”的最低限度的抗生素治疗。在夏季放养和冬季放养时分别监测牛粪中AMR细菌和基因的动态变化。我们将仔细监测那些患病并服用抗生素的牛和其他牛群。农场动物的饮食也可能影响其肠道菌群中AMR的增加。即使是牛在外出放牧时通常吃的草和三叶草等普通植物(“饲料”)也会产生天然的抗菌化合物,这些化合物可能在胃(瘤胃)中继续活跃,而瘤胃中有数百万细菌繁殖和繁殖。在冬天,牛被带到室内喂养青贮饲料,这是一种经过发酵保存的草地植物。未消化的食物和来自瘤胃的大量细菌,因此可能是抗菌素耐药性,在牛粪中排泄。我们将分析食用不同饲料类型的牛的粪便,以找出它们所吃的饲料是否会影响食用一种饲料的牛与食用另一种饲料的牛发生抗菌素耐药性的可能性。英国的大多数养牛场都位于多山的“潮湿的西部”,那里雨水将农田径流到水道中的可能性很高。由于气候变化,导致大量径流和洪水的最近暴风雨的增加预计将继续下去。与此同时,近年来越来越多的人认识到,抗菌素耐药性可能出现在农场动物身上,并从农场环境中释放到水中的自然环境中,最终可能进入饮用水、洗澡水或海鲜中。通常,使用粪便指示生物(FIOs)来监测水中牛粪的污染,这些细菌通常不会引起疾病,但与引起疾病的细菌(病原体)相关,并且可以由科学家安全地处理。了解fio中携带抗菌素耐药性的比例将是有用的,因为它们是常规检测的,有助于将来估计抗菌素耐药性的传播。我们将对从被肉牛放牧或用牛粪传播的田地流出的水进行取样,并分析水中的细菌,包括fio,看看它们是否对抗生素具有耐药性。这项研究的结果应该有助于我们了解在牛群中产生的抗菌素耐药性是否可能转移到环境中,管理是否可以限制抗菌素耐药性及其传播,并为评估新抗生素的风险和管理可能发生的不良反应提供方法。这是解决我们复杂的农业食品系统风险的重要工作,显然对消费者和农民都很重要。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cross Inoculation of Rumen Fluid to Improve Dry Matter Disappearance and Its Effect on Bacterial Composition Using an in vitro Batch Culture Model.
- DOI:10.3389/fmicb.2020.531404
- 发表时间:2020
- 期刊:
- 影响因子:5.2
- 作者:McDermott K;Lee MRF;McDowall KJ;Greathead HMR
- 通讯作者:Greathead HMR
Impacts of African swine fever on water quality in China
- DOI:10.1088/1748-9326/abe2ce
- 发表时间:2021-02
- 期刊:
- 影响因子:6.7
- 作者:Z. Bai;X. Jin;O. Oenema;Michael R. F. Lee;Jun Zhao;Lin Ma
- 通讯作者:Z. Bai;X. Jin;O. Oenema;Michael R. F. Lee;Jun Zhao;Lin Ma
Antimicrobial Resistance: Investigating the Environmental Dimension.
抗菌素耐药性:调查环境因素。
- DOI:
- 发表时间:2017
- 期刊:
- 影响因子:0
- 作者:Gaze W.H.
- 通讯作者:Gaze W.H.
Have we opened the floodgates on antimicrobial resistance?
我们是否打开了抗菌素耐药性的闸门?
- DOI:
- 发表时间:2017
- 期刊:
- 影响因子:0
- 作者:Gaze, W.H.
- 通讯作者:Gaze, W.H.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Michael Lee其他文献
Sustainable Composite Beam Behaviour with Deconstructable Bolted Shear Connectors
具有可解构螺栓剪力连接器的可持续复合梁行为
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
Michael Lee;M. Bradford - 通讯作者:
M. Bradford
A bifunctional Δ6‐fatty acyl acetylenase/desaturase from the moss Ceratodon purpureus
来自苔藓 Ceratodon purpureus 的双功能 Δ6-脂肪酰基乙酰化酶/去饱和酶
- DOI:
10.1046/j.1432-1327.2000.01418.x - 发表时间:
2000 - 期刊:
- 影响因子:5.4
- 作者:
P. Sperling;Michael Lee;T. Girke;U. Zähringer;S. Stymne;E. Heinz - 通讯作者:
E. Heinz
LCAT deficiency does not impair amyloid metabolism in APP/PS1 mice[S]
LCAT 缺乏不会损害 APP/PS1 小鼠的淀粉样蛋白代谢[S]
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:6.5
- 作者:
S. Stukas;L. Freeman;Michael Lee;Anna Wilkinson;A. Ossoli;B. Vaisman;S. Demosky;Jeniffer Y. Chan;Veronica Hirsch;A. Remaley;C. Wellington - 通讯作者:
C. Wellington
In vitro assessment of clastogenicity of mobile‐phone radiation (835 MHz) using the alkaline comet assay and chromosomal aberration test
使用碱性彗星试验和染色体畸变试验体外评估手机辐射(835 MHz)的致畸性
- DOI:
10.1002/tox.20347 - 发表时间:
2008 - 期刊:
- 影响因子:4.5
- 作者:
Ji;Sae;Young;S. Yu;W. Koh;Joong‐Rak Hong;Taeho Son;Sung;Michael Lee - 通讯作者:
Michael Lee
Paclitaxel-Induced G2/M Arrest via Different Mechanism of Actions in Glioma Cell Lines with Differing p53 Mutational Status
紫杉醇通过不同作用机制在不同 p53 突变状态的胶质瘤细胞系中诱导 G2/M 期停滞
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
B. Han;Michael Lee - 通讯作者:
Michael Lee
Michael Lee的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Michael Lee', 18)}}的其他基金
WORKSHOP: VL/HCC 2020 Graduate Consortium
研讨会:VL/HCC 2020 毕业生联盟
- 批准号:
2041418 - 财政年份:2020
- 资助金额:
$ 20.54万 - 项目类别:
Standard Grant
Increasing Urban Youth Participation in Computing through Mentorship and Coding Resources
通过指导和编码资源增加城市青年对计算的参与
- 批准号:
1837489 - 财政年份:2019
- 资助金额:
$ 20.54万 - 项目类别:
Standard Grant
CRII: Cyberlearning: Keeping Computer Programming Learners Engaged Online
CRII:网络学习:让计算机编程学习者在线参与
- 批准号:
1657160 - 财政年份:2017
- 资助金额:
$ 20.54万 - 项目类别:
Standard Grant
A metabonomic approach to identify biomarkers for bovine mycotoxicosis
鉴定牛霉菌中毒生物标志物的代谢组学方法
- 批准号:
BB/M006409/1 - 财政年份:2015
- 资助金额:
$ 20.54万 - 项目类别:
Research Grant
13TSB_N4L2FS: Development of silage inoculants to improve mineral composition of animal products
13TSB_N4L2FS:开发青贮饲料接种剂以改善动物产品的矿物质成分
- 批准号:
BB/L021285/1 - 财政年份:2014
- 资助金额:
$ 20.54万 - 项目类别:
Research Grant
NSF East Asia and Pacific Summer Institute for FY 2012 in Korea
NSF 东亚及太平洋地区 2012 财年韩国暑期学院
- 批准号:
1210205 - 财政年份:2012
- 资助金额:
$ 20.54万 - 项目类别:
Fellowship Award
Exploring the basis of cannabinoid analgesia in humans
探索人类大麻素镇痛的基础
- 批准号:
G0601340/1 - 财政年份:2007
- 资助金额:
$ 20.54万 - 项目类别:
Fellowship
Collaborative Research and Development of Prototype Java-Based Learning Materials for the Environment of Undergraduate Electrodynamics
本科生电动力学环境下基于Java的原型学习资料的协同研发
- 批准号:
0127438 - 财政年份:2002
- 资助金额:
$ 20.54万 - 项目类别:
Standard Grant
Evaluating models of category learning that use general feature-based representations
评估使用基于通用特征的表示的类别学习模型
- 批准号:
ARC : DP0211406 - 财政年份:2002
- 资助金额:
$ 20.54万 - 项目类别:
Discovery Projects
Computer Science, Engineering, and Mathematics Scholarships Program
计算机科学、工程和数学奖学金计划
- 批准号:
9987171 - 财政年份:2000
- 资助金额:
$ 20.54万 - 项目类别:
Standard Grant
相似国自然基金
TRPV1受体在盐敏感性高血压过程中所介导的肾脏保护作用的机理研究
- 批准号:81170243
- 批准年份:2011
- 资助金额:60.0 万元
- 项目类别:面上项目
气体信号分子硫化氢对颈动脉窦压力反射感受器的调节作用及机制
- 批准号:81100181
- 批准年份:2011
- 资助金额:20.0 万元
- 项目类别:青年科学基金项目
HCN4在心房颤动肺静脉电位形成中作用的研究
- 批准号:81000082
- 批准年份:2010
- 资助金额:20.0 万元
- 项目类别:青年科学基金项目
Transient Receptor Potential 通道 A1在膀胱过度活动症发病机制中的作用
- 批准号:30801141
- 批准年份:2008
- 资助金额:28.0 万元
- 项目类别:青年科学基金项目
感觉神经递质CGRP通过与P物质的相互作用改善心肌缺血的机制探讨
- 批准号:30801213
- 批准年份:2008
- 资助金额:20.0 万元
- 项目类别:青年科学基金项目
人脐血间充质干细胞成骨潜能亚群的特异性分子标志
- 批准号:30800232
- 批准年份:2008
- 资助金额:20.0 万元
- 项目类别:青年科学基金项目
脂肪干细胞软骨潜能亚群的特异性分子标志
- 批准号:30772264
- 批准年份:2007
- 资助金额:28.0 万元
- 项目类别:面上项目
相似海外基金
CAREER: Transformation potential of per- and polyfluoroalkyl substances (PFAS) in drinking water distribution systems
职业:全氟烷基物质和多氟烷基物质 (PFAS) 在饮用水分配系统中的转化潜力
- 批准号:
2338480 - 财政年份:2024
- 资助金额:
$ 20.54万 - 项目类别:
Continuing Grant
I-Corps: Translation Potential of a Secure Data Platform Empowering Artificial Intelligence Assisted Digital Pathology
I-Corps:安全数据平台的翻译潜力,赋能人工智能辅助数字病理学
- 批准号:
2409130 - 财政年份:2024
- 资助金额:
$ 20.54万 - 项目类别:
Standard Grant
I-Corps: Translation Potential of Mechanically Compliant Fracture Fixation Plates for Long Bone Fractures
I-Corps:用于长骨骨折的机械顺应性骨折固定板的平移潜力
- 批准号:
2410029 - 财政年份:2024
- 资助金额:
$ 20.54万 - 项目类别:
Standard Grant
I-Corps: Translation Potential of Rapid In-situ Forming Gel for Local Gene Delivery
I-Corps:快速原位形成凝胶用于局部基因传递的转化潜力
- 批准号:
2410778 - 财政年份:2024
- 资助金额:
$ 20.54万 - 项目类别:
Standard Grant
I-Corps: Translation potential of 3D electronics manufacturing by integrated 3D printing and freeform laser induction
I-Corps:通过集成 3D 打印和自由形式激光感应实现 3D 电子制造的转化潜力
- 批准号:
2412186 - 财政年份:2024
- 资助金额:
$ 20.54万 - 项目类别:
Standard Grant
I-Corps: Translation potential of a tampon-like menstrual cup and applicator system
I-Corps:卫生棉条状月经杯和涂抹器系统的翻译潜力
- 批准号:
2413962 - 财政年份:2024
- 资助金额:
$ 20.54万 - 项目类别:
Standard Grant
I-Corps: Translation potential of stereolithography 3D printing to create soft elastomers
I-Corps:立体光刻 3D 打印制造软弹性体的转化潜力
- 批准号:
2414710 - 财政年份:2024
- 资助金额:
$ 20.54万 - 项目类别:
Standard Grant
I-Corps: Translation Potential of Head Impact Monitoring with Embedded Sensor Technology in Sports Helmets
I-Corps:运动头盔中嵌入式传感器技术的头部碰撞监测的转化潜力
- 批准号:
2416207 - 财政年份:2024
- 资助金额:
$ 20.54万 - 项目类别:
Standard Grant
I-Corps: Translation potential of learning engagement and assessment programs in multi-person virtual reality
I-Corps:多人虚拟现实中学习参与和评估项目的翻译潜力
- 批准号:
2417857 - 财政年份:2024
- 资助金额:
$ 20.54万 - 项目类别:
Standard Grant
I-Corps: Translation Potential of a High Throughput Drug Discovery Platform for Protein Degraders
I-Corps:蛋白质降解剂高通量药物发现平台的转化潜力
- 批准号:
2419488 - 财政年份:2024
- 资助金额:
$ 20.54万 - 项目类别:
Standard Grant