CENTER FOR STRUCTURAL AND FUNCTIONAL NEUROSCIENCE

结构和功能神经科学中心

• 批准号: 6285194
• 负责人: RICHARD J. BRIDGES
• 金额: $ 147.12万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6285194
• 关键词: neurosciences

The long range goal of this project is to establish a Center of Biomedical Research Excellence that serves two primary function: i) to advance our understanding of Structural and Functional Neuroscience and ii) to increase the number of NIH-RO1-funded investigators in Montana. We propose to create a Center for Structural and Functional Neuroscience at the University of Montana using a well balanced combination of new faculty recruitment, development of needed instrumentation, and sub- project support for talented young faculty already in place. Research in the proposed Center will emphasize CNS protein structure and function as related to signal transduction, development and neurodegeneration. This thematic focus, not only builds on existing faculty strengths, but also represents a field in which interdisciplinary research at a growing University (without a medical school) can make a significant contribution to one of the highest priority health care issues facing our nation: understanding and lessening the burden of neurological diseases. The proposed Center will be developed using the following specific aims: Aim I - Enhance the critical mas of competitive neuroscientists at the University of Montana through strategic recruitment of three new faculty. Aim II - Promote the development of competitive neuroscience faculty through the support of individual subprojects Aim III - Enhance the infrastructure for neuroscience research through the acquisition of critically needed instrumentation for a shared core spectroscopy lab for studies of CNS protein structure and function. Aim IV - Establish a support network for Center neuroscientists that promotes infrastructure development, collaborative interaction and, most importantly, mentoring.

该项目的长期目标是建立一个生物医学研究卓越中心，该中心有两个主要功能：i)促进我们对结构和功能神经科学的理解；ii)增加由NIH-RO1资助的蒙大拿州研究人员的数量。我们建议在蒙大拿大学建立一个结构和功能神经科学中心，利用新教师招聘、所需仪器的开发以及已经到位的有才华的年轻教师的子项目支持的良好组合。拟建中心的研究将侧重于与信号转导、发育和神经变性相关的中枢神经系统蛋白质结构和功能。这一主题关注不仅建立在现有教员优势的基础上，而且代表着一个领域，在一个不断发展的大学(没有医学院)进行的跨学科研究可以为我国面临的最优先的医疗保健问题之一做出重大贡献：了解和减轻神经疾病的负担。拟建的中心将按照以下具体目标发展：目标I-通过战略性招聘三名新教员，加强蒙大拿大学竞争性神经科学家的关键能力。目标二--通过支持个别子项目促进具有竞争力的神经科学教师队伍的发展--目标三--通过为研究中枢神经系统蛋白质结构和功能的共享核心光谱学实验室购置急需的仪器，加强神经科学研究的基础设施。目标IV-为中心神经科学家建立一个支持网络，促进基础设施发展、协作互动，最重要的是，指导。