Distinct populations of Arc NPY neurons control different aspects of energy homeostasis

Arc NPY 神经元的不同群体控制能量稳态的不同方面

• 批准号: nhmrc : 1144819
• 负责人: Prof Herbert Herzog
• 金额: $ 57.02万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/distinct-populations-arc-energy-homeostasis/1320286
• 关键词: Distinct; populations; Arc; NPY; neurons

Obesity is caused by an imbalance of energy intake and energy expenditure both of which are controlled by specific neurons in the brain. While different types of neurons important in these processes have been identified how they are organised and work in fulfilling the different functions is unclear. Here we aim to identify subpopulations of neurons that are responsible for specific tasks that would make them more specific targets for drug intervention with a reduced risk of side effects.

肥胖是由能量摄入和能量消耗不平衡引起的，这两者都由大脑中的特定神经元控制。虽然已经确定了在这些过程中重要的不同类型的神经元，但它们是如何组织和实现不同功能的仍不清楚。在这里，我们的目标是识别负责特定任务的神经元亚群，这将使它们成为药物干预的更具体目标，同时降低副作用风险。