Investigation of the role of the peripheral neuropeptide Y system in energy homeostasis

外周神经肽Y系统在能量稳态中作用的研究

• 批准号: nhmrc : 1028882
• 负责人: Prof Herbert Herzog
• 金额: $ 53.26万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-role-peripheral-energy-homeostasis/110666
• 关键词: Investigation; role; peripheral; neuropeptide; system

Obesity-associated diseases are leading causes of death and are expected to increase as the obesity epidemic worsens. Because of the limited efficacy and/or safety concerns of currently available anti-obesity drugs, it is important to identify new drug targets, preferably outside the brain. The results from this study will help to identify agents for obesity that reduce body weight and fat mass without the safety concerns of agents that act on the central nervous system.

与肥胖相关的疾病是导致死亡的主要原因，随着肥胖流行病的恶化，预计这种疾病会增加。由于目前可用的抗肥胖药物的有效性和/或安全性问题有限，因此确定新的药物靶点非常重要，最好是在大脑外。这项研究的结果将有助于确定减少体重和脂肪量的肥胖药物，而不担心作用于中枢神经系统的药物的安全性。