Identification of novel pathways controlling food intake and energy balance

识别控制食物摄入和能量平衡的新途径

• 批准号: nhmrc : 1045166
• 负责人: Prof Herbert Herzog
• 金额: $ 50.08万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-novel-pathways-energy-balance/111723
• 关键词: Identification; novel; pathways; controlling; food

Obesity-associated diseases are leading causes of death and are expected to increase as the obesity epidemic worsens. Because of the limited efficacy and/or safety concerns of currently available anti-obesity drugs, it is important to identify new drug targets. Investigating the cause of obesity and excessive food intake in natural occurring models like Prader Willi Syndrome (PWS) has the potential to shed new light on the complex regulation of this process and might open up new treatment option for PWS as well as general obese patients.

与肥胖有关的疾病是死亡的主要原因，预计随着肥胖症的流行，这种疾病还会增加。由于目前可用的抗肥胖药物的有限的功效和/或安全性问题，重要的是确定新的药物靶点。在自然发生的模型如Prader Willi综合征（PWS）中调查肥胖和过量食物摄入的原因有可能揭示这一过程的复杂调节，并可能为PWS以及一般肥胖患者开辟新的治疗选择。