The role of the NPY system in health and disease

NPY 系统在健康和疾病中的作用

• 批准号: nhmrc : 1019734
• 负责人: Prof Herbert Herzog
• 金额: $ 49.34万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-npy-health-disease/109979
• 关键词: role; NPY; system; health; disease

Obesity-associated diseases are a major health problem and treatments are ineffective. My team’s focus is to determine how a brain molecule called neuropeptide Y (NPY) controls appetite and body fat mass and how this is changed in obesity or in the other extreme, anorexia, which is common in late stage cancer. We will use genetically modified mouse models and investigate the role of NPY under different stress conditions and in cancer. This will tell us if targeting this NPY system with drugs may provide a treatment for these diseases.

肥胖相关疾病是一个主要的健康问题，治疗无效。我的团队的重点是确定一种名为神经肽Y（NPY）的大脑分子如何控制食欲和体脂量，以及这在肥胖症或另一个极端厌食症中是如何改变的，厌食症在晚期癌症中很常见。我们将使用转基因小鼠模型，研究不同应激条件下和癌症中NPY的作用。这将告诉我们，如果用药物靶向这种NPY系统，可能会为这些疾病提供治疗。